- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03220438
TMS Enhancement of Visual Plasticity in Schizophrenia
Testing TMS Enhancement of Visual Plasticity in Schizophrenia
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Maryland
-
Baltimore, Maryland, United States, 21228
- University of Maryland
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- age: 18-65,
- no neurological illness, head trauma, or major medical illness,
- not pregnant or nursing,
- no contraindication for TMS or MRI scanning,
- no current substance abuse/dependence.
Healthy controls will have no DSM-5 diagnosis and no first-degree relatives with a psychotic disorder.
Inclusion criteria for patients includes:
- DSM-5 diagnosis of schizophreniform, schizophrenia or schizoaffective and competent to sign an informed consent,
- not currently taking other medications that affects brain structure (e.g. steroids),
- less than 12 months antipsychotic exposure and on the same psychotropic medications for 4 weeks prior to study,
- not be taking clozapine (due to its effects on NMDA receptors and increase of seizure threshold),
- clinically stable (i.e. no change in psychotic symptoms for at least 4 weeks).
Exclusion Criteria:
- age outside of 18-65,
- neurological illness, head trauma, or major medical illness,
- pregnant or nursing,
- contraindication for TMS or MRI scanning,
- current substance abuse/dependence,
- currently taking medications that affects brain structure (e.g. steroids).
Healthy controls with a DSM-5 diagnosis and/or a first-degree relative with a psychotic disorder. Participants with schizophrenia that are not competent to sign an informed consent, have more than 12 months antipsychotic exposure, not on the same psychotropic medications for 4 weeks prior to study, taking clozapine, and not clinically stable (i.e.a change in psychotic symptoms for at least 4 weeks).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: TMS
rTMS
|
Transcranial Magnetic Stimulation
|
Sham Comparator: Sham TMS
A sham coil will be used.
This condition controls for the auditory artifacts induced by rTMS.
|
Transcranial Magnetic Stimulation
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
fMRI BOLD response of visual plasticity
Time Frame: 4 hours
|
fMRI BOLD response of visual plasticity
|
4 hours
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
MRS assessment of glutamate
Time Frame: 4 hours
|
occipital cortical glutamate levels
|
4 hours
|
Collaborators and Investigators
Investigators
- Principal Investigator: Laura M Rowland, PhD, University of Maryland, Baltimore
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HP-00072640
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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