the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting

Comparative Study of the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting After Scleral Buckling Under General Anesthesia

Sponsors

Lead Sponsor: Cairo University

Source Cairo University
Brief Summary

Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances Incidence of PONV after general anesthesia is about 30% in all post-surgical patients but up to 80% in high-risk patients despite advances in anesthetics and anesthesia techniques

Detailed Description

Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances.

The incidence of PONV after general anesthesia is about 30% in all post-surgical patients but up to 80% in high-risk patients despite advances in anesthetics and anesthesia techniques.

Despite new antiemetic drugs the overall incidences remain high especially in subjects with increased patient-related risk-factors such as in female gender, non-smoking status, a history of motion sickness or previous PONV, inhalational anesthetics, certain types of surgery, and opioid use. Scleral buckling (SB) which is still thought to be the most efficacious and cost-effective primary procedure for the treatment of uncomplicated retinal detachment is often associated with postoperative pain as well as nausea and vomiting. Preoperative injections of local anesthetics via retrobulbar, peribulbar, or subtenon routes in patients undergoing vitreoretinal surgery under general anesthesia (GA) have been reported to reduce postoperative pain, nausea, and vomiting.

Topical lidocaine drops have also has been used intraoperatively to decrease the incidence and severity of the OCR and to prevent pain and PONV after strabismus surgery and vitrectomy without scleral buckling .

The current study was designed to compare the effect of three different analgesic techniques ; IV analgesia , peribulbar block and topical xylocaine jel on the incidence of ponv after scleral buckling under general anesthesia.

Overall Status Unknown status
Start Date October 30, 2017
Completion Date January 1, 2018
Primary Completion Date November 30, 2017
Study Type Observational
Primary Outcome
Measure Time Frame
PONV 8 hours post operative
Enrollment 75
Condition
Intervention

Intervention Type: Drug

Intervention Name: Dexmedetomidine

Description: Dexmedetomidine will be given with GS

Arm Group Label: Group 1

Other Name: Dexmedetomidine with scleral buckling

Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

- males or females

- aged between 18-80 years

- ASA physical status Ι&II -indicated for repair of retinal detachment with scleral buckling. -

Exclusion Criteria:

- Patients with cardiac, liver and/or kidney diseases

- coagulation defects or receiving anticoagulants

- hypersensitivity to the used drugs

- history of motion sickness or PONV

- diabetes mellitus

- gastrointestinal disease

- smokers

- menstruating ladies

- ASA status more than II

Gender: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Healthy Volunteers: No

Overall Contact

Last Name: Hassan Ali, lecturer

Phone: 1001733687

Email: [email protected]

Location
Facility: Contact: Cairo University HASSAN M ALI, LECTURER +201001733687 [email protected]
Location Countries

Egypt

Verification Date

October 2017

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Cairo University

Investigator Full Name: Hassan Mohamed Ali

Investigator Title: lecturer of anesthesia

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: Group 1

Description: GA and Dexmedetomidine

Label: group 2

Description: GA and peribulbar

Label: group3

Description: GA and xylocaine gel

Patient Data No
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov