- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03333837
Improvisational Movement for People With Memory Loss and Their Caregivers (IMOVE)
IMOVE: Improvisational Movement for People With Memory Loss and Their Caregivers
Study Overview
Status
Intervention / Treatment
Detailed Description
Dementia is a progressive decline in cognition that impairs a person's ability to perform activities of daily living. Alzheimer's disease is the most common form of dementia, the most common neurodegenerative disease in older adults, and the 6th leading cause of death in the US. Neuropsychiatric symptoms (apathy, depression, anxiety) and altered gait and balance are prominent secondary symptoms of Alzheimer's disease that increase medical costs and decrease quality of life for both the person with dementia and their caregiver.
In a report from the Secretariat (Executive Board, 134th Session, December 20th, 2013), the World Health Organization identified a need to integrate evidence-based palliative care services into the continuum of care for serious chronic diseases, including Alzheimer's disease. However, two recent NIH workshops identified major gaps in the evidence supporting the wider use of non-pharmacologic activities to ameliorate secondary symptoms of chronic disease. Arts-based activities were identified as particularly understudied for symptom management, given growing evidence that various arts-based activities can improve quality of life, relieve symptoms, and reduce reliance on medications. It is important that these benefits can be achieved without adding medications. Dance is an arts-based activity that can improve quality of life, decrease symptoms of depression, and improve balance in healthy older adults, those with Parkinson disease, and Alzheimer's disease. Thus, dance is a non-pharmacological intervention that simultaneously addresses two sets of prominent secondary symptoms in Alzheimer's disease: 1) gait and balance and 2) neuropsychiatric symptoms. However, the mechanisms through which dance exerts these effects are unknown.
Pilot data from the investigators' laboratory suggest that participating in a group improvisational movement class twice weekly improved balance and connectivity in motor-related brain regions, as well as improving mood and connectivity in brain regions associated with social engagement. Improvisation is the ability to create new gestures and movements spontaneously. Improvisation can be a part of many different art forms. However, improvisational movement can also be practiced as a specific dance form. The objective in improvisational movement is that choreographed movement is replaced by a cue or prompt that allows the possibility for multiple responses. This unique form of dance is especially well-suited for people with dementia because it: 1) does not rely heavily on memory of repeated movements; 2) can be seamlessly adapted to include sitting, standing, or moving around the room; 3) is cognitively challenging; and 4) fosters a social, playful atmosphere. Participants seemed to benefit from both the social nature of the class and the movement. Therefore, the overall aim of this proposal is to experimentally determine the independent and combined effects of dance movement and social engagement on quality of life in people with early stage dementia, and test the neural mechanisms of these effects.
To accomplish this goal, the investigators will use a 2x2 factorial design and randomize 120 community-dwelling older adults adjudicated as having early-stage dementia of the presumed Alzheimer's type to one of four 3-month interventions: 1) Dance Group, 2) Non-group Dance, 3) Social Group, or 4) No Contact Control.
It is not hypothesized that dance affects the underlying disease course, and therefore no improvement is expected in cognition.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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North Carolina
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Winston-Salem, North Carolina, United States, 27104
- Wake Forest Baptist Health
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Age 60-85 years
Adjudicated as having mild cognitive impairment or early-stage dementia of Alzheimer's, vascular, or mixed Alzheimer's/vascular type
MRI compatible
English speaking
Have study partner who is around the person with dementia approximately 10 hours/week and is willing to be an active study partner.
Able to attend bi-weekly intervention classes or come to study visits for no-contact control.
Not enrolled in another interventional study for at least 3 months prior to beginning this study.
Exclusion Criteria:
Untreated depression
Other causes of dementia (for example, frontotemporal, early onset, Lewy body or Parkinsonian dementia)
Current cancer treatment or other major medical problems that might independently affect cognition or movement
Other neurological disorders (e.g., Parkinson disease, multiple sclerosis)
Taking medication that could negatively influence safety during intervention
Planned extensive travel during the study period
Any reason for which the study doctor or personal physician feels the intervention is contraindicated for the participant
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Active Comparator: Dance Group
The Dance Group will participate in 1-hour group improvisational dance lessons 2x/week for 12 weeks.
Improvisational dance classes are grounded in 4 principles that shape the tone of the class and result in a sense of social belonging: non-judgment, non-competitiveness, curiosity, and playfulness.
The following training strategies are used to maintain: active imagination, variability, and pacing.
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Active imagination refers to working with imagery and is crucial in improvisatory practice.
Verbal auditory cues are used to create movement scenarios that cue or activate the motor imagination.
Variability means the improvisational method does not aim to learn a specific movement pattern and habituate to it.
Cues are delivered quickly, one after another.
Within an average of two minutes, tasks requiring quicker decision-making are introduced.
Pacing is the rate at which new movement prompts are presented.
Quick changes in pace avoid defaulting to habitual responses, thereby facilitating new movement options.
Participants cannot rely on copying another, memory, or anticipation to address the motor problem.
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Active Comparator: Non-group Dance
The Non-group dance intervention is designed to capture the same dance movement and auditory stimuli as the group class without social interaction.
Recordings of the dance instructor teaching a dance class will be played.
This will ensure participants hear comparable music and receive comparable verbal auditory cues to prompt dance movements that students in the group class will hear, without interacting with other people.
Improvisational dance is particularly suited for this means of delivery because the primary method of instruction is verbal auditory cueing.
Participants will be asked to follow the same schedule as participants in the Dance Group arm and complete 2 one-hour dance sessions each week.
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The caregiver will be asked to stay in the area while the subject is dancing.
A video camera will be affixed in an upper corner of the room to record individual dance sessions.
This recording will yield data that a trained student or staff member can view and code to document movement fidelity (e.g., that the person has responded to the dance prompts and for the purpose of comparing the amount of quality of movements that occur in individual vs. group dance settings).
For the first two sessions, study staff would observe the full dance session from outside the room to be sure that instruction was clear and adherence was attained, and that no safety issues arise.
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Active Comparator: Social Group
The social group will consist of improvisational party games to foster curiosity and playfulness, use imagery, and encourage non-judgment.
Games that may be used include 'Balderdash', 'Wise and Otherwise', 'Charades', 'Pictionary', and 'Tell Me A Story' cards.
These games will also use the same core strategies as the dance group.
Games will be varied within an hour-long session to incorporate pacing and variability into the social group, akin to the dance group.
The social group will occur 2x/week for 1 hour each time and be led by the same instructors who lead the Dance Group, to control for effects of personality of the group leader.
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The social group will consist of improvisational party games to foster curiosity and playfulness, use imagery, and encourage non-judgment.
Games that may be used include 'Balderdash', 'Wise and Otherwise', 'Charades', 'Pictionary', and 'Tell Me A Story' cards.
These games will also use the same core strategies as the dance group.
Games will be varied within an hour-long session to incorporate pacing and variability into the social group, akin to the dance group.
The social group will occur 2x/week for 1 hour each time and be led by the same instructors who lead the Dance Group, to control for effects of personality of the group leader.
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Sham Comparator: No Contact
A No Contact condition captures the condition of no added social contact and no added dance movement.
Participants randomized to the No Contact condition will be asked to continue their current disease management and lifestyle for 12 weeks
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The condition of not receiving an intervention can have ethical implications and reduce retention rates.
Therefore, these participants will be invited to join in a weekly community improvisational dance class after they complete the study, for as many sessions as they would like.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Quality of Life in Alzheimer's Disease (QOL-AD)--Participants With Dementia (PWD)
Time Frame: Baseline
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Self-reported quality of life in the person with dementia is the primary outcome and will be measured using the QOL-AD .
The QOL-AD is validated for use in people with Mini Mental State Exam scores as low as 10.The QOL_AD contains 13 items.Points are assigned to each item as follows: poor = 1, fair = 2, good = 3, excellent = 4.The total score is the sum of all 13 item (range 13- 52) higher scores represent better outcomes.
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Baseline
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QOL-AD--PWD
Time Frame: Week 12
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Self-reported quality of life in the person with dementia is the primary outcome and will be measured using the QOL-AD .
The QOL-AD is validated for use in people with Mini Mental State Exam scores as low as 10.The QOL_AD contains 13 items.Points are assigned to each item as follows: poor = 1, fair = 2, good = 3, excellent = 4.The total score is the sum of all 13 item (range 13- 52) higher scores represent better outcomes.
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Week 12
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Community Structure--PWD
Time Frame: Baseline
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This is a brain imaging variable derived from fMRI images.
Modularity (Q) ranges from 0 (no community structure) to 1 (perfectly modular network).
One Q-value is generated for each person and group averages are shown.
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Baseline
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Community Structure--PWD
Time Frame: Week 12
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This is a brain imaging variable derived from fMRI images.
Modularity (Q) ranges from 0 (no community structure) to 1 (perfectly modular network).
One Q-value is generated for each person and group averages are shown.
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Week 12
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Global Efficiency (eGlob)--PWD
Time Frame: Baseline
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This is a brain imaging variable derived from fMRI images.Scale ranges from 0 (no long-range information processing) to 1 (maximal distributed processing).
Decreased Eglob has been associated with aging, cognitive impairment, and depression.
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Baseline
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Global Efficiency (eGlob)--PWD
Time Frame: Week 12
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This is a brain imaging variable derived from fMRI images.Scale ranges from 0 (no long-range information processing) to 1 (maximal distributed processing).
Decreased Eglob has been associated with aging, cognitive impairment, and depression.
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Week 12
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Local Efficiency (eLoc)--PWD
Time Frame: Baseline
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Scale ranges from 0 (no local connectivity) to 1 (maximal local connectivity - all connections are local) and has been observed to change with cognitive impairment and depression.
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Baseline
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Local Efficiency (eLoc)--PWD
Time Frame: Week 12
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Scale ranges from 0 (no local connectivity) to 1 (maximal local connectivity - all connections are local) and has been observed to change with cognitive impairment and depression.
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Week 12
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Path Length--PWD
Time Frame: Baseline
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Refers to the number of edges that must be crossed to get from one node to another.
Longer path length in people with AD has been associated with slower cognitive performance, beta amyloid deposition, and depression.
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Baseline
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Path Length--PWD
Time Frame: Week 12
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Refers to the number of edges that must be crossed to get from one node to another.
Longer path length in people with AD has been associated with slower cognitive performance, beta amyloid deposition, and depression.
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Week 12
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Fullerton Advanced Balance Scale (Overall Balance) PWD
Time Frame: Baseline
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Fullerton Advanced Balance Scale (FAB) measures balance using 10 different performance-based tests (scored 0 worst - 4 best), including; standing with feet together and eyes closed, standing on a foam pad with eyes closed, walking while turning the head from side to side rhythmically, functional standing reach, turning around to the left and right, stepping up and over a 6-inch box, standing on one leg, and a test for postural reaction.
The scale goes from 0-40 with 40 being the best outcome and a cutoff of <=25 for risk of falls.
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Baseline
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Fullerton Advanced Balance Scale (Overall Balance) PWD
Time Frame: Week 12
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Fullerton Advanced Balance Scale (FAB) measures balance using 10 different performance-based tests (scored 0 worst - 4 best), including; standing with feet together and eyes closed, standing on a foam pad with eyes closed, walking while turning the head from side to side rhythmically, functional standing reach, turning around to the left and right, stepping up and over a 6-inch box, standing on one leg, and a test for postural reaction.
The scale goes from 0-40 with 40 being the best outcome and a cutoff of <=25 for risk of falls.
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Week 12
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Falls Efficacy Scale - International (FES) PWD
Time Frame: Baseline
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A 16-item scale to assess fear of falling where higher scores reflect a higher fear and risk of falling.
Out of a total score of 100, a score of 70 or above indicates the individual has a fear of falling.
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Baseline
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Falls Efficacy Scale - International (FES) PWD
Time Frame: Week 12
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A 16-item scale to assess fear of falling where higher scores reflect a higher fear and risk of falling.
Out of a total score of 100, a score of 70 or above indicates the individual has a fear of falling.
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Week 12
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Neuropsychiatric Inventory Questionnaire (NPI-Q)
Time Frame: Baseline
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The NPI is a reliable and valid structured interview designed to assess neuropsychiatric symptoms in person with dementia through a structured interview with the caregiver.
The NPI includes questions about 12 domains of symptoms: delusions, hallucinations, agitation/aggression, depression, anxiety, elation/ euphoria, apathy, disinhibition, irritability, aberrant motor activity, sleep, and eating.
For each, symptom severity is scored on a scale of 0-4, with 4 being the worst outcome and caregiver distress is scored on a scale from 0-5, with 5 being the worst outcome.
The sum of all 12 domains is calculated.
Severity scores are reported here with a range from 0-36 with a higher score reflecting greater symptom severity.
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Baseline
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NPI-Q
Time Frame: Week 12
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The NPI is a reliable and valid structured interview designed to assess neuropsychiatric symptoms in person with dementia through a structured interview with the caregiver.
The NPI includes questions about 12 domains of symptoms: delusions, hallucinations, agitation/aggression, depression, anxiety, elation/ euphoria, apathy, disinhibition, irritability, aberrant motor activity, sleep, and eating.
For each, symptom severity is scored on a scale of 0-4, with 4 being the worst outcome and caregiver distress is scored on a scale from 0-5, with 5 being the worst outcome.
The sum of all 12 domains is calculated.
Severity scores are reported here with a range from 0-36 with a higher score reflecting greater symptom severity.
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Week 12
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Geriatric Depression Scale
Time Frame: Baseline
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The person with dementia will be asked to complete a screening tool for assessing depression.
This test has 15 yes/no questions with a yes receiving 1 point for a depressive answer.
A total score is calculated and will be on a scale from 0-15 with 0-4 indicating no depression, 5-10 suggestive of a mild depression, and 11+ suggestive of severe depression.
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Baseline
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Geriatric Depression Scale
Time Frame: Week 12
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The person with dementia will be asked to complete a screening tool for assessing depression.
This test has 15 yes/no questions with a yes receiving 1 point for a depressive answer.
A total score is calculated and will be on a scale from 0-15 with 0-4 indicating no depression, 5-10 suggestive of a mild depression, and 11+ suggestive of severe depression.
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Week 12
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Geriatric Anxiety Scale
Time Frame: Baseline
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The Geriatric Anxiety Scale measures symptoms of anxiety in older adults.
A single total score ranges from 0 (low anxiety) to 63 (high anxiety).
Four cutoff scores have been provided by authors in the manuals: 0-7 (normal anxiety), 8-15 (mild-moderate anxiety), 16-25 (moderate-severe anxiety), and 26-63 (severe anxiety).
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Baseline
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Geriatric Anxiety Scale
Time Frame: Week 12
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The Geriatric Anxiety Scale measures symptoms of anxiety in older adults.
A single total score ranges from 0 (low anxiety) to 63 (high anxiety).
Four cutoff scores have been provided by authors in the manuals: 0-7 (normal anxiety), 8-15 (mild-moderate anxiety), 16-25 (moderate-severe anxiety), and 26-63 (severe anxiety).
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Week 12
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Apathy Evaluation Scale--PWD
Time Frame: Baseline
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The Apathy Evaluation Scale (AES) addresses characteristics of goal directed behavior that reflect apathy including behavioral, cognitive, and emotional indicators.
A short form will be used that has been modified for use with people with dementia.
This shortened version has 10 questions scored 1-4 with 4 being the positive outcome answer.
The total score is calculated and on a scale of 10-40 with lower scores reflecting less apathy and thus a better outcome.
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Baseline
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Apathy Evaluation Scale--PWD
Time Frame: Week 12
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The Apathy Evaluation Scale (AES) addresses characteristics of goal directed behavior that reflect apathy including behavioral, cognitive, and emotional indicators.
A short form will be used that has been modified for use with people with dementia.
This shortened version has 10 questions scored 1-4 with 4 being the positive outcome answer.
The total score is calculated and on a scale of 10-40 with lower scores reflecting less apathy and thus a better outcome.
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Week 12
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Expanded Short Physical Performance Battery (eSPPB)
Time Frame: Baseline
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The eSPPB is a brief test of global mobility function with excellent test-retest and inter-examiner reliability; is sensitive to change; is safe, and is a robust predictor of future physical disability and death.
To avoid ceiling effects, investigators will use an expanded version (eSPPB) that increases the difficulty of the standing balance task by asking participants to hold postures for 30 instead of 10 seconds, adds a one-leg stand, and adds a narrow walk.
The resulting score is normally distributed, continuous, and shows greater sensitivity to change.
Dementia patients have lower scores on the SPPB so a favorable outcome for this outcome measure would be a significantly higher score post treatment.
The eSPPB is scored as a continuous measure with a minimum score of 0 and a maximum score of 3.0 where 3 is the best possible outcome.
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Baseline
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Expanded Short Physical Performance Battery (eSPPB)
Time Frame: Week 12
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The eSPPB is a brief test of global mobility function with excellent test-retest and inter-examiner reliability; is sensitive to change; is safe, and is a robust predictor of future physical disability and death.
To avoid ceiling effects, investigators will use an expanded version (eSPPB) that increases the difficulty of the standing balance task by asking participants to hold postures for 30 instead of 10 seconds, adds a one-leg stand, and adds a narrow walk.
The resulting score is normally distributed, continuous, and shows greater sensitivity to change.
Dementia patients have lower scores on the SPPB so a favorable outcome for this outcome measure would be a significantly higher score post treatment.
The eSPPB is scored as a continuous measure with a minimum score of 0 and a maximum score of 3.0 where 3 is the best possible outcome.
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Week 12
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Postural Sway--PWD
Time Frame: Baseline
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Center of pressure displacement (area of the 95% confidence ellipse) using an AccuSway forceplate.
Center of pressure displacement is one way to characterize postural sway.
Increased postural sway is correlated with decreased balance in older adults and increased fall risk.
Center of pressure displacement was measured using the area of the 95% confidence ellipse using an AccuSway forceplate.
Higher numbers indicate greater levels of postural sway.
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Baseline
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Postural Sway--PWD
Time Frame: Week 12
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Center of pressure displacement (area of the 95% confidence ellipse) using an AccuSway forceplate.
Center of pressure displacement is one way to characterize postural sway.
Increased postural sway is correlated with decreased balance in older adults and increased fall risk.
Center of pressure displacement was measured using the area of the 95% confidence ellipse using an AccuSway forceplate.
Higher numbers indicate greater levels of postural sway.
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Week 12
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Gait Speed--PWD
Time Frame: Baseline
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The time one takes to walk a specified distance on level surfaces over a short distance.
4m usual gait speed was measured as part of the eSPPB.
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Baseline
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Gait Speed--PWD
Time Frame: Week 12
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The time one takes to walk a specified distance on level surfaces over a short distance.
4m usual gait speed was measured as part of the eSPPB.
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Week 12
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Gait Variability--PWD
Time Frame: Baseline
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Stride time variability, which is calculated out of the mean and standard deviation of stride time, reflects the change in time elapsed between the first two contacts of two consecutive footfalls of the same foot over a number of gait cycles.
Increased gait variability is associated with increased fall risk in older adults.
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Baseline
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Gait Variability--PWD
Time Frame: Week 12
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Stride time variability, which is calculated out of the mean and standard deviation of stride time, reflects the change in time elapsed between the first two contacts of two consecutive footfalls of the same foot over a number of gait cycles.
Increased gait variability is associated with increased fall risk in older adults.
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Week 12
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
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Body Mass Index (BMI)
Time Frame: Baseline, Week 12
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a measure of body fat based on height and weight that applies to adult men and women--PWD only
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Baseline, Week 12
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Blood Pressure
Time Frame: Baseline, Week12
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PWD only
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Baseline, Week12
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Neuroticism-Extraversion-Openness Five-Factor Inventory (NEO-FFI)
Time Frame: Baseline
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A measure of five domains of personality (neuroticism, extraversion, openness, agreeableness, and conscientiousness).
A higher score on any scale indicates stronger presence of that trait.
PWD only
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Baseline
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White Matter Lesion Burden
Time Frame: Baseline, Week 12
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The volume of white matter lesions is calculated using the Lesion Segmentation Toolbox.
PWD only.
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Baseline, Week 12
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Blood-based Stress Biomarkers (Covariate or Alternative Hypothesis)
Time Frame: Baseline, Week 12
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Social engagement may change biomarkers of stress relevant for interpreting outcomes.
These stress biomarkers include cortisol and allostatic load, a composite measure of blood-based biomarkers associated with chronically elevated stress.
PWD only
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Baseline, Week 12
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Caregiver Quality of Life With the 36-item Short-Form Health (SF-36)--Covariate or Alternative Hypothesis
Time Frame: Baseline, Week 12
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The SF-36 consists of 36 questions assessing physical functioning, role functioning difficulties caused by physical problems, bodily pain, general health, vitality, social functioning, role functioning difficulties caused by emotional problems, and mental health.
High scores are representative of a great health status and better outcomes, while low scores are representative of a poor health status.
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Baseline, Week 12
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Caregiver Burden With Zarit Caregiver Burden Scale--Covariate or Alternative Hypothesis
Time Frame: Baseline, Week 12
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The Zarit Caregiver Burden Scale is administered in interview form to the caregiver.
It consists of 22 questions scored 0-4 with 0=Never, 1=Rarely, 2=Sometimes, 3=Quite Frequently, 4=Nearly Always.
The total score range is 0-88 with 88 being the worst possible outcome.
0-20 represents little or no burden on the caregiver, 21-40 represents mild to moderate burden, 41-60 represents moderate to severe burden, and 61-88 represents severe burden.
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Baseline, Week 12
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Collaborators and Investigators
Investigators
- Principal Investigator: Christina Hugenschmidt, PhD, Assistant Professor Gerontology and Geriatric Medicine
Publications and helpful links
General Publications
- Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feelings of burden. Gerontologist. 1980 Dec;20(6):649-55. doi: 10.1093/geront/20.6.649. No abstract available.
- Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992 Jun;30(6):473-83.
- Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994 Mar;49(2):M85-94. doi: 10.1093/geronj/49.2.m85.
- Petzinger GM, Fisher BE, McEwen S, Beeler JA, Walsh JP, Jakowec MW. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease. Lancet Neurol. 2013 Jul;12(7):716-26. doi: 10.1016/S1474-4422(13)70123-6.
- LIFE Study Investigators, Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S. Effects of a physical activity intervention on measures of physical performance: Results of the lifestyle interventions and independence for Elders Pilot (LIFE-P) study. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1157-65. doi: 10.1093/gerona/61.11.1157. Erratum In: J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):337.
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- Cummings JL. The Neuropsychiatric Inventory: assessing psychopathology in dementia patients. Neurology. 1997 May;48(5 Suppl 6):S10-6. doi: 10.1212/wnl.48.5_suppl_6.10s.
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- Sharp K, Hewitt J. Dance as an intervention for people with Parkinson's disease: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2014 Nov;47:445-56. doi: 10.1016/j.neubiorev.2014.09.009. Epub 2014 Sep 28.
- Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJM, Daubenmier J, Estay I, Hills NK, Chainani-Wu N, Carroll PR, Blackburn EH. Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 2013 Oct;14(11):1112-1120. doi: 10.1016/S1470-2045(13)70366-8. Epub 2013 Sep 17.
- Verghese J, Wang C, Lipton RB, Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci. 2013 Apr;68(4):412-8. doi: 10.1093/gerona/gls191. Epub 2012 Sep 17.
- Okura T, Langa KM. Caregiver burden and neuropsychiatric symptoms in older adults with cognitive impairment: the Aging, Demographics, and Memory Study (ADAMS). Alzheimer Dis Assoc Disord. 2011 Apr-Jun;25(2):116-21. doi: 10.1097/WAD.0b013e318203f208.
- Verghese J, Lipton RB, Katz MJ, Hall CB, Derby CA, Kuslansky G, Ambrose AF, Sliwinski M, Buschke H. Leisure activities and the risk of dementia in the elderly. N Engl J Med. 2003 Jun 19;348(25):2508-16. doi: 10.1056/NEJMoa022252.
- Gaugler JE, Yu F, Krichbaum K, Wyman JF. Predictors of nursing home admission for persons with dementia. Med Care. 2009 Feb;47(2):191-8. doi: 10.1097/MLR.0b013e31818457ce. Erratum In: Med Care. 2009 May;47(5):606.
- Committee, S.o.t.F., State of the Field Report: Arts in Healthcare 2009, 2009, Society for the Arts in Healthcare: Washington, DC.
- Verghese J. Cognitive and mobility profile of older social dancers. J Am Geriatr Soc. 2006 Aug;54(8):1241-4. doi: 10.1111/j.1532-5415.2006.00808.x.
- Coubard OA, Duretz S, Lefebvre V, Lapalus P, Ferrufino L. Practice of contemporary dance improves cognitive flexibility in aging. Front Aging Neurosci. 2011 Sep 20;3:13. doi: 10.3389/fnagi.2011.00013. eCollection 2011.
- Earhart GM. Dance as therapy for individuals with Parkinson disease. Eur J Phys Rehabil Med. 2009 Jun;45(2):231-8.
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Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Mental Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Neurologic Manifestations
- Neurobehavioral Manifestations
- Neurocognitive Disorders
- Neurodegenerative Diseases
- Dementia
- Tauopathies
- Cognition Disorders
- Alzheimer Disease
- Cognitive Dysfunction
- Memory Disorders
- Amnesia
Other Study ID Numbers
- IRB00042460
- R01AT009444 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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