- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03407053
Effect of Ultra Processed Versus Unprocessed Diets on Energy Intake
Background:
Eating too much processed food is believed to lead to obesity. But the effect of processed food on energy intake has not been carefully studied. Researchers want to study people s diets for 4 weeks and do specialized tests of the effects. Participants will get two diets. They will have the same calories and nutrients, but one diet will be unprocessed food and the other will be ultra-processed.
Objective:
To better understand how processed and unprocessed foods affect daily food consumption and how the body handles blood sugar.
Eligibility:
Healthy adults ages 18-50 who have stable weight and can exercise
Design:
Participants will not eat for 12 hours. Then they will be screened with:
- Medical history
- Physical exam
- Heart and blood tests
- Resting energy expenditure test (REE). A hood will collect air exhaled while lying down for 30-40 minutes.
- Psychiatric questions
- Questions about mood, eating, sleep, and socioeconomic status
- 20-minute stationary biking
Female participants will have a urine pregnancy test.
Participants will stay in the clinic for 4 weeks. For 2 weeks they will get a processed diet. For the other 2 weeks they will get an unprocessed diet. Participants cannot use the study period to gain or lose weight.
Participants will have:
- Meals and snacks provided
- Daily exercise
- Blood, urine, and saliva tests
- To drink a special water and a very sweet liquid
- REE
- Scans and X-rays
- To wear activity monitors and a device to measure blood sugar
- Several 24-hour periods in a room that measures oxygen and carbon dioxide
- Repeats of screening questions
- Questions about hunger and meals
- Sleep monitoring
- Taste tests
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Maryland
-
Bethesda, Maryland, United States, 20892
- National Institutes of Health Clinical Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
INCLUSION CRITERIA:
- Adults age 18-50 years, male and female
- Weight stable (< +/- 5 % over past 6 months)
4. Body mass index (BMI) greater than or equal to 18 kg/m^2
5. Willing to cease their habitual caffeine intake during the study, beginning one week prior to inpatient admission
6. Written informed consent
7. Willing to eat the food provided in the study
8. Able to complete daily bouts of stationary cycling at a moderate rate and intensity with a heart rate (HR) equal to or greater than 0.3x(220-age-HR(rest))+HR(rest) but not exceeding 0.4x(220-age-HR(rest))+HR(rest) and no signs of arrhythmia
EXCLUSION CRITERIA:
- Evidence of metabolic or cardiovascular disease, or disease that may influence metabolism (e.g. cancer, diabetes, thyroid disease)
- Taking any prescription medication or other drug that may influence metabolism (e.g. diet/weight-loss medication, asthma medication, blood pressure medication, psychiatric medications, corticosteroids, or other medications at the discretion of the PI and/or study team)
- Hematocrit < 34% (women only)
- Hematocrit < 40% (men only)
- Pregnancy, lactation (women only)
- Participating in a regular exercise program (> 2h/week of vigorous activity)
- Caffeine consumption > 300 mg/day
- Regular use of alcohol (> 2 drinks per day), tobacco (smoking or chewing) amphetamines, cocaine, heroin, or marijuana over past 6 months
Eating disorders or psychological conditions, such as (but not limited to) claustrophobia, clinical depression, bi-polar disorders, that would be incompatible with safe and successful participation in this study, as determined by investigators.
--Past or present history of claustrophobia since part of the protocol will involve being confined to a small room for whole-body indirect calorimetry and being in an MRI scanner for liver fat measures
- Implants, devices, or foreign objects implanted in the body that interfere with the Magnetic Resonance procedures
- Volunteers with strict dietary concerns (e.g. vegetarian or kosher diet, food allergies)
- Volunteers unwilling or unable to give informed consent
- Non-English speakers due to unavailability of required questionnaires in other languages.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Ultra-processed diet then unprocessed diet
Participants assigned to this arm will consume ultra-processed diet for two weeks followed by unprocessed diet for two weeks
|
Consuming ultra-processed diet over a 2-week period
Consuming unprocessed diet over a 2-week period
|
Active Comparator: Unprocessed diet then ultra-processed diet
Participants assigned to this arm will consume unprocessed diet for two weeks followed by ultra-processed diet for two weeks
|
Consuming ultra-processed diet over a 2-week period
Consuming unprocessed diet over a 2-week period
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Ad Libitum Energy Intake
Time Frame: 14 days
|
Ad libitum energy intake averaged over 14 days for each diet, measured in kilocalories (kcal) per day.
|
14 days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in Body Weight
Time Frame: Baseline and day 14
|
Change in body weight from baseline to day 14 for each diet, measured in kilograms (kg)
|
Baseline and day 14
|
Change in Fat Mass
Time Frame: Baseline and day 14
|
Change in body fat mass from baseline to day 14 for each diet, measured in kilograms (kg).
Body fat mass was measured using Dual-energy X-ray absorptiometry (DXA) measurements.
|
Baseline and day 14
|
Collaborators and Investigators
Publications and helpful links
General Publications
- Hall KD, Ayuketah A, Brychta R, Cai H, Cassimatis T, Chen KY, Chung ST, Costa E, Courville A, Darcey V, Fletcher LA, Forde CG, Gharib AM, Guo J, Howard R, Joseph PV, McGehee S, Ouwerkerk R, Raisinger K, Rozga I, Stagliano M, Walter M, Walter PJ, Yang S, Zhou M. Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metab. 2019 Jul 2;30(1):67-77.e3. doi: 10.1016/j.cmet.2019.05.008. Epub 2019 May 16. Erratum In: Cell Metab. 2019 Jul 2;30(1):226. Cell Metab. 2020 Oct 6;32(4):690.
- Howard R, Guo J, Hall KD. Imprecision nutrition? Different simultaneous continuous glucose monitors provide discordant meal rankings for incremental postprandial glucose in subjects without diabetes. Am J Clin Nutr. 2020 Oct 1;112(4):1114-1119. doi: 10.1093/ajcn/nqaa198.
Helpful Links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 180044
- 18-DK-0044 (Other Identifier: NIH Clinical Center)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Healthy Diet
-
University of ReadingActive, not recruitingDiet Modification | Diet, Healthy | Diet HabitUnited Kingdom
-
University of ManitobaNot yet recruitingHealthy | Healthy Diet
-
Washington State UniversityUnited States Department of Agriculture (USDA)Not yet recruitingHealth Behavior | Diet, Healthy | Diet HabitUnited States
-
Luis María Béjar PradoRecruitingHealthy Eating Index | Mediterranean Diet | Diet HabitsSpain
-
University of MinnesotaRecruiting
-
Swiss Federal Institute of TechnologyCompletedHealthy Aging | Healthy DietSwitzerland
-
University of HawaiiPennington Biomedical Research Center; United States Department of Agriculture...RecruitingDiet, HealthyUnited States
-
Harokopio UniversityRecruiting
-
Universitas Katolik Widya Mandala SurabayaNot yet recruitingDiet, HealthyIndonesia
-
Ohio State University Comprehensive Cancer CenterRecruitingHealthy DietUnited States
Clinical Trials on Ultra-processed diet
-
Wageningen UniversityNext Food Collective (previously TKI agri-food program and TiFN, Top Institute...Recruiting
-
Virginia Polytechnic Institute and State UniversityRecruiting
-
National Institute of Diabetes and Digestive and...RecruitingObesity | Healthy DietUnited States
-
Rutgers, The State University of New JerseyRecruitingEnvironmental Exposure | Food SelectionUnited States
-
Virginia Polytechnic Institute and State UniversityRecruiting
-
University of California, San FranciscoRecruitingDepression | Obesity | Metabolic Syndrome | Weight Gain | Major Depressive DisorderUnited States
-
Drexel UniversityRecruitingObesity | Food Addiction | OvereatingUnited States
-
Oklahoma State UniversityRecruiting
-
University of CopenhagenDeakin University; Monash HealthCompletedOvernutrition | Fertility Issues | Nutrition, Healthy | Epigenetic DisorderDenmark
-
USDA Beltsville Human Nutrition Research CenterNational Cattlemen's Beef AssociationActive, not recruiting