Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.

Study Overview

• Status: Completed
• Conditions: Healthy Aging; Healthy Diet
• Intervention / Treatment: Other: 5min respiratory muscle exercises; Other: 15min respiratory muscle exercises

• Study Type: Interventional
• Enrollment (Actual): 42
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Christina M. Spengler, Prof.; Phone Number: +41 44 635 5007; Email: christina.spengler@hest.ethz.ch

Study Locations

• Switzerland
  • ZH
    • Zürich, ZH, Switzerland, 8057
      • Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Age ≥18 years
• Healthy
• Non-smoking
• Body mass index (BMI): 18.5 - 29.9 kg∙m-2
• Normal lung function
• Willing to adhere to study rules

Exclusion Criteria:

• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
• Previous enrolment into the current study
• Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Pregnancy, breastfeeding, or intention to become pregnant during the study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Respiratory Muscle Exercises; Two respiratory muscle exercises	Other: 5min respiratory muscle exercises; 5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose; Other: 15min respiratory muscle exercises; 5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose
No Intervention: Control; The control intervention consists of quiet sitting for 15 min

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Peak blood glucose concentration	Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).	throughout the study, an expected average of 2 weeks per participant
area under the glucose-time curve	Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).	throughout the study, an expected average of 2 weeks per participant

Collaborators and Investigators

• Sponsor: Swiss Federal Institute of Technology
• Investigators: Principal Investigator: Christin M. Spengler, Prof., Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Study record dates

Study Major Dates

• Study Start (Actual): August 20, 2020
• Primary Completion (Actual): April 21, 2022
• Study Completion (Actual): April 21, 2022

Study Registration Dates

• First Submitted: August 17, 2020
• First Submitted That Met QC Criteria: August 19, 2020
• First Posted (Actual): August 20, 2020

Study Record Updates

• Last Update Posted (Actual): March 17, 2023
• Last Update Submitted That Met QC Criteria: March 16, 2023
• Last Verified: March 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: HOGTT_2020

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No