Psychosocial Outcomes and Transition Readiness in Uveitis

Describing Relationships Between Psychosocial Outcomes and Readiness for Transition in Adolescent and Young Adult Patients With Uveitis - a Pilot Study

It is widely acknowledged that the transition from paediatric to adult health services should be a multidimensional and multidisciplinary process that addresses the medical, psychosocial, and educational needs of adolescents and young adults (AYA). Despite this, there is currently a scarcity of research examining the relationships between psychosocial factors (e.g., anxiety, social support) and transition readiness in AYA with uveitis. This study therefore aims to examine the relationships between psychosocial factors and transition readiness in pre-transfer adolescents and post-transfer young adults aged 10-25 years diagnosed with JIA at a single centre.

In total, 25 adolescents aged 10-16 years, together with a parent/guardian, will participate at Sheffield Children's Hospital and 10 young adults aged 16-25 years will participate at Sheffield Teaching Hospitals. Participants completed a battery of self-report questionnaire measuring psychosocial factors (anxiety/depression, social support, family functioning, health-related quality of life) and transition readiness (transition knowledge and skills, self-efficacy). Uveitis disease severity was also measured during clinic appointments. A subset of participants will also be asked to take part in a focus group. This study received full ethical approval, and all participants will give their written informed assent or consent before taking part.

Study Overview

• Status: Completed
• Conditions: Uveitis

• Study Type: Observational
• Enrollment (Actual): 56

Contacts and Locations

Study Locations

• United Kingdom
  • Sheffield, United Kingdom
    • Sheffield Children's NHS Foundation Trust

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 10 years to 25 years (ADULT, CHILD)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The study population will either be uveitis patients aged 10-25 years or parents/guardians of uveitis patients aged 10-16 years.

Description

Inclusion Criteria:

• Diagnosis of uveitis
• Uveitis managed by either Sheffield Children's NHS Foundation Trust or Sheffield Teaching Hospitals NHS Foundation Trust
• Fluent in English

Exclusion Criteria:

• No diagnosis of uveitis
• Uveitis not managed by either Sheffield Children's NHS Foundation Trust or Sheffield Teaching Hospitals NHS Foundation Trust
• Not fluent in English

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort
Pre-Transfer Adolescents aged 10-16 years
Post-Transfer Young Adults aged 16-25 years
Parents/Guardians of Pre-Transfer Patients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Generalised Anxiety	Generalised Anxiety Disorder-7 Questionnaire (Spitzer et al., 2006)	Day 1, when participants complete the study questionnaire

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Depression	Patient Health Questionnaire-9 (Spitzer et al., 1999)	Day 1, when participants complete the study questionnaire
Health-related quality of life	Paediatric Quality of Life Generic Module (Varni et al., 2002)	Day 1, when participants complete the study questionnaire
Social support	Bath Adolescent Pain Questionnaire Social Support Subscale (Eccleston et al., 2005)	Day 1, when participants complete the study questionnaire
Family functioning	Bath Adolescent Pain Questionnaire Family Functioning Subscale (Eccleston et al., 2005)	Day 1, when participants complete the study questionnaire
Prosocial and problem behaviours	Strengths and Difficulties Questionnaire (Goodman, 1997)	Day 1, when participants complete the study questionnaire
Uveitis disease severity	Standardization of uveitis nomenclature (SUN) scores will be used to assess uveitis disease severity.	Day 1, during hospital clinic appointment

Collaborators and Investigators

• Sponsor: Sheffield Children's NHS Foundation Trust
• Collaborators: Sheffield Teaching Hospitals NHS Foundation Trust

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 3, 2018
• Primary Completion (ACTUAL): August 14, 2018
• Study Completion (ACTUAL): August 14, 2018

Study Registration Dates

• First Submitted: May 21, 2018
• First Submitted That Met QC Criteria: May 31, 2018
• First Posted (ACTUAL): June 13, 2018

Study Record Updates

• Last Update Posted (ACTUAL): September 7, 2018
• Last Update Submitted That Met QC Criteria: September 6, 2018
• Last Verified: September 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Eye Diseases; Uveal Diseases; Uveitis
• Other Study ID Numbers: SCH-2174

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No