Long Term Effect of Splenectomy on Metabolism

Long-term Effect of Splenectomy on Metabolism, a Retrospective Cohort Study

Metabolic status of patients who had gone through trauma splenectomy between July 2008 and July 2013 were compared to patients who had gone through bowel resection due to obstruction in the same period of time. all patients were followed up for 5-10 years.

Study Overview

• Status: Completed
• Conditions: Trauma Splenic
• Intervention / Treatment: Diagnostic test: Blood sample

Detailed Description

A list was made of patients who had gone through trauma splenectomy or bowel resection due to bowel obstruction in our center between July 2008 and July 2013. Patients were divided into two groups: trauma splenectomy (exposed group) and bowel resection (unexposed group).

All patients were followed up for 5-10 years. Of the 243 splenectomized patients, 90 patients who met our study criteria were willing to participate. Of 152 patients with bowel resection, 64 were willing to participate. Records of patients at the time of surgery were retrieved from hospital archive of patients' records. Patients were invited to an office meeting for assessment of blood pressure, BMI and a general physical examination and history taking. An appointment was made for drawing blood samples for measurement of lipid profile, Hb A1C and fasting blood sugar.

Exclusion criteria:

1. Disturbed lipid profile at the time of surgery, 2. Disturbed blood glucose levels at the time of surgery, 3. History of high blood pressure prior to surgery, 4. Use of any hyperglycemogenic agent during the follow up period, 5. BMI>= 25 at the time of surgery, 6. History of diseases potentially affecting blood glucose, e.g. hyperthyroidism, Cushing syndrome, 7. Accidental pancreatic damage during surgery, 8. Resection of >10 cm of small bowel and 9. History of malignancy or radiotherapy (criteria 8 and 9 were specific to unexposed group).

• Study Type: Observational
• Enrollment (Actual): 154

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients who had gone through bowel resection due to obstruction or trauma splenectomy in Imam Hosein General Hospital between July 2008 and July 2013

Description

Inclusion Criteria:

• trauma splenectomy or bowel resection due to obstruction between July 2008 and July 2013

Exclusion Criteria:

• disturbed lipid profile at the time of surgery
• disturbed blood glucose at the time of surgery
• history of high blood pressure at the time of surgery
• use of any hyperglcemogenic agent during the follow up
• BMI>= 25 at the time of surgery
• history of diseases that can affect blood glucose levels
• accidental pancreatic damage during surgery
• resection of > 10 cm of small bowel (for bowel resection group)
• history of malignancy or radiotherapy (for bowel resection group)

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Trauma splenectomized; Patients who had gone through trauma splenectomy. BMI, lipid profile, blood pressure and glucose tolerance of patients were assessed. Hb A1C and lipid profile were assessed through blood sampling.	Diagnostic test: Blood sample; Blood sample for Hb A1C and lipid profile, blood pressure and BMI; Other Names: BMI and blood pressure measurement
Bowel resection; Patients who had gone through bowel resection due to obstruction. BMI, lipid profile, blood pressure and glucose tolerance of patients were assessed. Hb A1C and lipid profile were assessed through blood sampling.	Diagnostic test: Blood sample; Blood sample for Hb A1C and lipid profile, blood pressure and BMI; Other Names: BMI and blood pressure measurement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucose tolerance	Glucose tolerance was assessed by measuring the Hb A1C of the patients in both groups.	July 2008- July 2013

Collaborators and Investigators

• Sponsor: Imam Hossein General Hospital
• Investigators: Study Director: Behzad Nemati Honar, professor, Imam Hosein General Hospital; Principal Investigator: Sahar Saeedi, MD, Imam Hosein General Hospital

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2008
• Primary Completion (Actual): July 1, 2018
• Study Completion (Actual): August 1, 2018

Study Registration Dates

• First Submitted: August 18, 2018
• First Submitted That Met QC Criteria: August 23, 2018
• First Posted (Actual): August 27, 2018

Study Record Updates

• Last Update Posted (Actual): August 27, 2018
• Last Update Submitted That Met QC Criteria: August 23, 2018
• Last Verified: August 1, 2018

More Information

Terms related to this study

• Keywords: diabetes; stem cells; metabolism; Splenectomy; trauma surgery
• Other Study ID Numbers: ImamHGH

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Details of patients identities and data obtained from measurements will not be shared with other researchers.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No