Embryo Transfer With Self-spent Culture Medium

Can Embryo Transfer With Self-spent Culture Medium Improve Clinical Pregnancy Outcomes in Vitro Fertilization - Embryo Transfer Process?

Embryo Transfer With Self-spent Culture Medium or new Culture Medium in Vitro Fertilization - Embryo Transfer Process, to analyze which way can improve clinical pregnancy outcomes, is there a significant difference between the two?

Study Overview

• Status: Completed
• Conditions: in Vitro Fertilization
• Intervention / Treatment: Procedure: Self-spent Culture Medium

Detailed Description

Although some metabolites are present in self-spent culture medium, there are some embryonic exocrine factors secreted by embryo.These factors may have a positive impact on embryo implantation and subsequent development. So it is necessary to compare the two ways of embryo transfer with Self-spent Culture Medium or New Culture Medium in vitro fertilization - embryo transfer process.

The purpose of this study is to analyze which way can improve clinical pregnancy and birth outcomes, is there a significant difference between the two?

• Study Type: Interventional
• Enrollment (Actual): 335
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Shandong
    • Jinan, Shandong, China, 250013
      • Jinan Central Hospital Affiliated to Shandong University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• Infertility female patients with tubal factors,
• Infertile female patients with spouse factors

Exclusion Criteria:

• Intrauterine adhesions,
• Endometriosis,
• Primary ovarian insufficiency，
• Infectious disease

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Screening
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Self-spent Culture Medium; Changing embryo transfer solution with self-spent culture medium	Procedure: Self-spent Culture Medium; Replace embryo transfer solution with Self-spent culture medium in IVF-ET.
No Intervention: New Culture Medium; embryo transfer with new culture medium in IVF-ET

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of Participants Pregnant After 4 Weeks	Observe the clinical pregnancy rate under different embryo transfer methods	4 weeks
Live Birth	Observe the live birth rate under different embryo transfer methods	40 weeks

Collaborators and Investigators

• Sponsor: Bin Wu
• Investigators: Study Director: Yingchun zhang, Dr, Jinan Central Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2018
• Primary Completion (Actual): December 31, 2019
• Study Completion (Actual): December 31, 2019

Study Registration Dates

• First Submitted: October 29, 2018
• First Submitted That Met QC Criteria: October 31, 2018
• First Posted (Actual): November 1, 2018

Study Record Updates

• Last Update Posted (Actual): January 27, 2020
• Last Update Submitted That Met QC Criteria: January 14, 2020
• Last Verified: December 1, 2019

More Information

Terms related to this study

• Keywords: Embryo Transfer
• Other Study ID Numbers: JianCH-RM001

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No