Severity Index of Neonatal Septicemia Using Score for Neonatal Acute Physiology (SNAP) II

Severity Index of Neonatal Septicemia of Cases Admitted at Neonatal Intensive Care Units at CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and at ELGALAA Children's MILITARY HOSPITAL Using Score for Neonatal Acute Physiology (SNAP) II

Sponsors

Lead Sponsor: Ahmed Mahmoud Ali Ali Youssef

Source Cairo University
Brief Summary

To determine the effect of Score for Neonatal Acute Physiology II as a Predictor of Mortality and Organ Dysfunction in Neonates with Septicemia in the Neonatal Intensive Care Units at CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and at ELGALAA Children's MILITARY HOSPITAL.

Detailed Description

This study will be conducted at the Neonatal intensive care Units at CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and at ELGALAA Children's MILITARY HOSPITAL.

Population of study & disease condition:

Neonates with septicemia admitted to NICUs in CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and in ELGALAA Children's MILITARY HOSPITAL.

Inclusion criteria:

1. Type of patient: Neonates with septicemia.

2. Age of patient: From 0-28 Days.

3. Sex: males and females.

Exclusion criteria:

1. Neonates with proved inborn error of metabolism.

2. Neonates with multiple congenital anomalies.

3. Neonates with severe birth asphyxia (APGAR score <4 at 5 minutes).

Methodology in details:

We will have 2 groups, each of them 50 neonates with septicemia. One group of premature neonates (32-36 weeks), the other group of full term neonates (>37 weeks).

All included Patients will be subjected to the following:

1. Full history with emphasis of relevant data as follows:

Date of birth, gestational age (AGA or SGA), gender, day of sepsis onset.

2. Clinical assessment:

Full systems examination.

3. Diagnosis of sepsis:

- By abnormal Total leucocytic count or I/T ratio or CRP with clinical Suggestion (poor feeding, hepatomegaly, apnea, tachypnea, lethargy, …).

- Confirm diagnosis by blood culture.

Sepsis will be considered severe if the neonate has sepsis plus one of the following: 1) cardiovascular organ dysfunction (hypotension or need for vasoactive drug) 2) 2 of the following (metabolic acidosis, increase lactic acid, oliguria, Prolonged capillary refill time) 3) Organ dysfunction (respiratory, renal, neurologic, hematologic).

4. SNAP II score:

For all neonates included in the study and its data collection within 24 hours from onset of sepsis, in the form of:

- Lowest mean blood pressure.

- Worst ratio of pao2/fio2

- Lowest temperature.

- Lowest serum PH.

- Occurrence of multiple seizures.

- Urine output<1 ml/kg/hour.

5. Follow up:

Follow up all neonates included in the study for 14 days: for morbidity and mortality.

6. Diagnosis of organ dysfunction:

Respiratory: by CXR and clinical examination. CVS: by blood pressure, capillary refill time, shock and need for inotropes. Renal: by urine output, kidney function tests. Hematology: by picture of DIC or pancytopenia. Neurology: by seizures, dilated fixed pupil.

Possible Risk:

None.

Primary outcomes:

Using Score for Neonatal Acute Physiology II as a Predictor of Mortality and Organ Dysfunction in Neonates with Septicemia.

Secondary outcomes:

Early anticipation of clinical manifestations of sepsis which will correlate most with poor outcome.

Sample size:

100 Neonates with septicemia admitted to NICUs in CHILDREN'S HOSPITAL, CAIRO UNIVERSITY and in ELGALAA Children's MILITARY HOSPITAL.

Overall Status Completed
Start Date September 1, 2017
Completion Date September 14, 2018
Primary Completion Date August 31, 2018
Study Type Observational [Patient Registry]
Primary Outcome
Measure Time Frame
Using Score for Neonatal Acute Physiology II as a Predictor of Mortality and Organ Dysfunction in Neonates with Septicemia. through study completion, an average of 1 year
Secondary Outcome
Measure Time Frame
Early anticipation of clinical manifestations of sepsis which will correlate most with poor outcome. through study completion, an average of 1 year
Enrollment 100
Condition
Intervention

Intervention Type: Diagnostic Test

Intervention Name: score for neonatal sepsis

Description: score for neonatal sepsis to predict morbidity

Eligibility

Sampling Method: Probability Sample

Criteria:

Inclusion Criteria:

1. Type of patient: Neonates with septicemia.

2. Age of patient: From 0-28 Days.

3. Sex: males and females.

Exclusion Criteria:

1. Neonates with proved inborn error of metabolism.

2. Neonates with multiple congenital anomalies.

3. Neonates with severe birth asphyxia (APGAR score <4 at 5 minutes).

Gender: All

Minimum Age: N/A

Maximum Age: 28 Days

Healthy Volunteers: No

Overall Official
Last Name Role Affiliation
Nermin R Mohamed, MD Principal Investigator Cairo University
Location
Facility: Faculty Of medicine Cairo University
Location Countries

Egypt

Verification Date

November 2018

Responsible Party

Type: Sponsor-Investigator

Investigator Affiliation: Cairo University

Investigator Full Name: Ahmed Mahmoud Ali Ali Youssef

Investigator Title: Doctor

Has Expanded Access No
Condition Browse
Arm Group

Label: Preterm neonates

Description: Neonates born between 32 and 37 weeks gestation

Label: Fullterm neonates

Description: Neonates born at or after 37 weeks gestation

Acronym SNAP
Patient Data No
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov