- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03851861
Dietary Intervention and Gastrointestinal Function in Patients With Parkinson's Disease (MED)
Study Overview
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Florida
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Gainesville, Florida, United States, 32611
- University of Florida
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Physician-diagnosed Parkinson's disease aged 21-85 years
- Hoehn & Yahr stage <3
- Currently living in the same household with a healthy spouse/partner who meets study eligibility criteria and is willing to participate
- Willing and able to complete informed consent in English
- Willing to complete daily and weekly questionnaires and 6 dietary recalls over approximately 7 weeks
- Willing to avoid beer, wine, and cocktails on the day before and the day of the sugar probe tests.
- Willing to provide urine and stool samples during the study collection periods.
- Willing and able to fast (no food or drink, except water or tea) for a prolonged period of time during study urine collections.
- Willing to maintain usual diet through the pre-baseline period
- Willing to make dietary changes to follow a Mediterranean dietary pattern during the intervention period.
- Willing to discontinue taking prebiotic, fiber, probiotic, herbal, or high-dose vitamin or mineral supplements that may impact inflammation during the pre-baseline period and throughout the study protocol.
- Willing to limit use of oral laxative medication to an "as-needed basis" (i.e. <3 times per week) during the full length of the study
- Willing to avoid high intensity exercises two days prior to and the day of the permeability tests. These tests will be done on two occasions.
- Willing to provide a social security number to receive study payment.
Exclusion Criteria:
- Does not meet above criteria
- Atypical or secondary Parkinsonism
- History of deep brain stimulation
- Daily use of NSAIDs in the last 3 months or incidental use in the last 2 weeks prior to screening.
- Daily use of anticholinergics or prokinetic agents
- Use of enemas or suppositories to alleviate constipation
- Use of another investigational product within 3 months of the screening visit.
- Antibiotic use within 2 months from the day of stool collection
- Good adherence to the Mediterranean diet during the pre-baseline period (score >6) based on the 14-item Mediterranean Diet Assessment Tool
- Physician-diagnosed gastrointestinal disease or condition (such as ulcerative colitis, Crohn's disease, gastroparesis, cancer, peptic ulcer disease, Celiac disease, short bowel disease, ileostomy, colostomy) other than gastroesophageal reflux or diverticular disease
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Mediterranean Diet
Participants will be given individualized diet education on the Mediterranean diet and instructed to follow the diet for the 5-week intervention period.
Individualized diet education will be administered by a licensed, registered dietitian nutritionist (RDN) followed by weekly phone calls to ensure compliance, improve adherence to the diet and monitor for adverse events.
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Participants will be instructed to include the following in their diet: a) abundant use of olive oil for cooking and dressing dishes; b) consumption of ≥2 daily servings of vegetables; c) ≥2-3 daily serving of fresh fruits (including natural juices); d) ≥3 weekly servings of legumes; e) ≥3 weekly servings of fish or seafood (at least one serving of fatty fish); f) ≥3 weekly serving of nuts or seeds; g) select white instead of red meats or processed meats (burgers, sausages); h) cook at least twice a week with a tomato herb sauce. Participants will be instructed to eliminate or limit the consumption of the following foods: cream, butter, margarine, cold meat, paté, duck, carbonated and/or sugared beverages, pastries, industrial bakery products and desserts, French fries or potato chips, and out-of-home pre-cooked cakes and sweets. For usual drinkers, the main source of alcohol should be wine. |
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Gastroduodenal Permeability
Time Frame: Week 1; Week 5
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The primary outcome is the change in gastroduodenal permeability induced by the Mediterranean diet.
Gastroduodenal permeability will be assessed by measuring sucrose concentration in the 0 to 5-hour urine collection (end of intervention minus baseline)
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Week 1; Week 5
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Small Intestinal Permeability
Time Frame: Week 1; Week 5
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The change in lactulose/rhamnose concentrations in a 5-hour urine collection (end of intervention minus baseline)
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Week 1; Week 5
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Colonic Permeability
Time Frame: Week 1; Week 5
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The change in sucralose/erythritol concentrations in a 5 to 24 hour urine collection (end of intervention minus baseline)
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Week 1; Week 5
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Whole Gut Permeability
Time Frame: Week 1; Week 5
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The change in sucralose/erythritol concentrations in a 0 to 24 hour urine collection (end of intervention minus baseline)
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Week 1; Week 5
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Stool Frequency
Time Frame: Week 1; Week 5
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Difference in the average number of weekly stools (end of intervention compared to baseline)
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Week 1; Week 5
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Stool Consistency
Time Frame: Week 1; Week 5
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Daily GI symptoms assessed using the Bristol Stool Scale (BSS).
Difference in the average BSS (end of intervention compared to baseline).
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Week 1; Week 5
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Gastrointestinal Symptoms
Time Frame: Week 1; Week 5
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Weekly GI symptoms assessed using the Gastrointestinal Symptom Rating Scale (GSRS).
The GSRS consists of 15 questions related to 5 syndromes, constipation, diarrhea, reflux, abdominal pain, and indigestion.
Symptoms are scored 1=no discomfort to 7=very severe discomfort.
Scores from each of the 15 questions are summed for the total GSRS score.
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Week 1; Week 5
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Bobbi Langkamp-Henken, PhD, RD, Univeristy of Florida
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB201900252
- OCR20178 (Other Identifier: UF OnCore)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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