- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03860649
Effects of Different Physical Therapies and Dance in People With Parkinson's Disease
Effects of Different Physical Therapies and Dance on Clinical and Functional Parameters, Muscle Quality, Pendular Mechanism of the Gait and Brain-derived Neurotrophic Factor in People With Parkinson's Disease
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Rio Grande Do Sul
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Porto Alegre, Rio Grande Do Sul, Brazil, 90690200
- Federal University of Rio Grande do Sul
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Volunteers
- aged over 40 years
- both sexes
- clinical diagnosis of idiopathic PD
- PD staging between 1 and 4 in Hoehn and Yahr Scale (H&Y).
Exclusion Criteria:
- performing recent surgeries, deep brain stimulation (DBS - Deep Brain Stimulations);
- severe heart diseases, uncontrolled hypertension, myocardial infarction within a period of less than one year, being a pacemaker;
- stroke or other associated neurological diseases; insanity;
- prostheses in the lower limbs;
- without ambulation conditions.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Nordic Walking
The patient walk program consists of 3 moments: warm up, walk and stretch.
They will do a brief free walking warm-up for 3 minutes in the Self-selected walking speed - SSWS (3 'SSWS), then walk according to the training cycle, the intensity will be between 60 to 80% of the Heart of Ratio reserve.
In addition, the intensity of the classes will be measured in each phase by the Borg Scale of Perceived Exertion.
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24 sessions will be held twice a week, with each session taking an average of 60 minutes.
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Experimental: Jogging
This group will undergo 24 Dance sessions.
Aquatic therapy patients will receive deep water running intervention with the use of flotation vests.
The exercises will consist of: immersion, balance, strength, agility, and movement within the water.
The intensity of the classes will be measured in each moment and by the Borg Scale of Perceived Exertion.
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24 sessions will be held twice a week, with each session taking an average of 60 minutes.
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Experimental: Dance
This group will undergo 24 Dance sessions inspired by Forró dance rhythm and Samba dance rhythm.
Classes will be divided into four stages: Joint warm up and stretching on the chairs; strengthening, balance and rhythm exercises with the support of the barre; exercises inspired by the Samba and Forró dance (Brazilian ballroom dance) basic steps; and Final cool down.
The intensity of the classes will be measured according to the beats per minute (BPMs) of the songs used in each moment and by the Borg Scale of Perceived Exertion.
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24 sessions will be held twice a week, with each session taking an average of 60 minutes.
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Experimental: Pilates Training
Classes composed of three phases: Warming up, main part and back to calm. Warming up will begin with pre-Pilates training exercises for 5 minutes (eg. breathing exercises, hip joint mobilization, shoulder girdle, etc.), the main part of the lesson will be the Pilates training drill sequence for the beginner level that will be conducted for 50 minutes in which all exercises will be performed on the floor. The sequence of the eighteen exercises of the main part of the lesson is described in the table below. Back to Calm: will be carried out for 5 final minutes with standing exercises with the subject reclining on the wall to reconnect the subject with orthostatic posture. In the each of the phases of the lesson will be shown to the subject the table of BORG with the objective of measuring the intensity of perceived exertion, using the Borg Scale of Perceived Exertion. |
24 sessions will be held twice a week, with each session taking an average of 60 minutes.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Test Timed Up and Go
Time Frame: Change from baseline at 12 weeks.
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Test Timed Up and Go This teste evaluate the mobility functional in three meters of self-selected speed (TUGSS) or at forced speed (TUGFS).
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Change from baseline at 12 weeks.
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Locomotor Rehabilitation Index
Time Frame: Change from baseline at 12 weeks.
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The Locomotor Rehabilitation Index (LRI) is a method of determining how close is the self-selected walking speed compared to the Optimum Speed.
The results is given in %, and when LRI value is closer to 100 %, it indicates that the participants are closer to their theoretical optimal walking speed.
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Change from baseline at 12 weeks.
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Self-selected walking speed
Time Frame: Change from baseline at 12 weeks.
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SSWS This outcome will be measure in test of walking treadmill.
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Change from baseline at 12 weeks.
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Optimal Walking Speed (OPT)
Time Frame: Change from baseline at 12 weeks.
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This outcome will be measure through of the registered image movement analysis using the three-dimensional motion analysis system (VICON) of the walking test on treadmill.
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Change from baseline at 12 weeks.
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Quality of life (QoL): PDQ-39
Time Frame: Change from baseline at 12 weeks.
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The quality of life will be measured by the Parkinson's Disease Questionnaire, with 39 questions (PDQ-39).
PDQ-39 is a PD specific health status questionnaire comprising 39 items.
Respondents are requested to affirm one of five ordered response categories according to how often, due to their PD, they have experienced the problem defined by each item.
The total scores are ranging between 0 and 100 points, that a lower score represents a greater perception of quality of life.
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Change from baseline at 12 weeks.
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Cognitive function - Montreal Cognitive Assessment
Time Frame: Change from baseline at 12 weeks.
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Montreal Cognitive Assessment (MoCA) is a brief screening tool for mild cognitive impairment.
This evaluation accesses different cognitive domains and investigates the individual's abilities in the following areas: attention and concentration, executive functions, memory, language, visuoconstructive skills, conceptualization, calculation and orientation.
The total score of the MoCA is 30 points, with a score of 26, or more, considered normal and less than 26 is considered cognitive impairment.
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Change from baseline at 12 weeks.
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Cognitive function - Mini Mental State Examination
Time Frame: Change from baseline at 12 weeks.
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Mini-Mental State Examination (MMSE) is a screening tool, used to identify dementia, which provides information on different cognitive parameters, containing questions grouped into seven categories that assess specific cognitive functions: temporal orientation, spatial orientation, three word registration, attention and calculation, recall of three words, language and visual constructive ability.
The MMSE score can range from zero to 30 points, in which a lower score indicates a higher degree of cognitive impairment.
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Change from baseline at 12 weeks.
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Depressive symptoms
Time Frame: Change from baseline at 12 weeks.
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This outcome will be measure for the Geriatric Depression Scale - 15 item.
The scale consists of 15 dichotomous questions in which participants are asked to answer yes or no in reference to how they felt over the past week (for instance, "Do the pacient feel that their life is empty?,"
Do the patient feel that their situation is hopeless?).
Scores range from 0 to 15 with higher scores indicating more depressive symptoms.
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Change from baseline at 12 weeks.
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Motor symptoms
Time Frame: Change from baseline at 12 weeks.
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This outcome will be evaluated using Unified Parkinson's Disease Rating Scale (UPDRS).
This Scale the clinician-scored monitored motor evaluation.
Will be to considered 30% improvement in motor symptoms has been applied to identify "responsive people".
The score in each item ranges from 0 to 4, and the indicates greater impairment by the disease and the minimum, normality.
The 14 items in the motor vehicle (the numbering of which goes from 18 to 31).
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Change from baseline at 12 weeks.
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Freezing of Gait
Time Frame: Change from baseline at 12 weeks.
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The freezing of gait questionnaire (FOG-Q) has 6 questions and a total score of 0 to 24.
A higher score corresponds to the more severe presence of freezing of gait and a lower score is equivalent to a lower presence or absence of freezing of gait .
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Change from baseline at 12 weeks.
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Balance Static
Time Frame: Change from baseline at 12 weeks.
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The force platform will be used for the anteroposterior displacement of the center of pressure (COP)- COPx (in centimeters) and mediolateral - COPy (in centimeters) of the pressure center.
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Change from baseline at 12 weeks.
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Spatial Parameter - Stride length
Time Frame: Change from baseline at 12 weeks.
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This outcome is measure by stride length in meters.
This parameter will be measure before and after the nordic walking, dance and jogging aquatic interventions.
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Change from baseline at 12 weeks.
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Temporal Parameter - Swing time, contact time, time of balance
Time Frame: Change from baseline at 12 weeks.
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Swing time in seconds, contact time in seconds, time of balance in seconds. The percentage of contact time will be calculated to measure the duty factor in percentual. The swing and contact time in seconds will be aggregated to distance in meters to arrive at frequency (in Hetz). These parameters will be measure before and after the nordic walking, dance and jogging aquatic interventions. |
Change from baseline at 12 weeks.
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Anthropometric data - Body mass
Time Frame: Change from baseline at 12 weeks.
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Body mass will be measure in kilograms before and after the nordic walking, dance and jogging aquatic interventions. These data will be measured in scale, stadiometer and anthropometric tape. All this parameters will be measure before and after the nordic walking, dance and jogging aquatic interventions. |
Change from baseline at 12 weeks.
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Anthropometric data - Height
Time Frame: Change from baseline at 12 weeks.
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Height will be measure in meters before and after the nordic walking, dance and jogging aquatic interventions.
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Change from baseline at 12 weeks.
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Anthropometric data - Circumference
Time Frame: Change from baseline at 12 weeks.
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Circumference of body will be measure in centimeters before and after the nordic walking, dance and jogging aquatic interventions.
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Change from baseline at 12 weeks.
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Anthropometric data - Body Mass Index
Time Frame: Change from baseline at 12 weeks.
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Weight and height will be combined to report the body mass index in kg/m2.
This parameter will be measure before and after the nordic walking, dance and jogging aquatic interventions.
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Change from baseline at 12 weeks.
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Electromyographic Parameters
Time Frame: Change from baseline at 12 weeks.
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This outcome is measure is a composite for: mean amplitude, onset, offset and time of the signal and co-contraction of the muscles: vastus lateralis (VL), biceps femoris (BF), anterior tibial (AT) and medial gastrocnemius (MG) all variables in percentage.
This outcome will be measured through measuring the electromyographic activation during treadmill walking tests using an electromyograph.
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Change from baseline at 12 weeks.
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Parameters of Pendular Mechanism - Internal Work
Time Frame: Change from baseline at 12 weeks.
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The transduction between the potential and kinetic mechanical energies of the center of body mass (called the "inverted pendulum" mechanism).
The internal work is the mechanical energy fluctuations of the movement of limbs relative to the center of body mass (Wint, in Joules).
This outcome will be measured through the registered image movement analysis using the three-dimensional motion analysis system VICON of the walking test on the treadmill.
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Change from baseline at 12 weeks.
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Parameters of Pendular Mechanism: external work
Time Frame: Change from baseline at 12 weeks.
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The transduction between the potential and kinetic mechanical energies of the center of body mass (called the "inverted pendulum" mechanism).
The external work is energy fluctuations of the center of body mass with respect to the external environment or surroundings (Wext, in Joules).
This outcome will be measured through the registered image movement analysis using the three-dimensional motion analysis system VICON of the walking test on the treadmill.
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Change from baseline at 12 weeks.
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Parameters of Pendular Mechanism: total mechanical work
Time Frame: Change from baseline at 12 weeks.
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The transduction between the potential and kinetic mechanical energies of the center of body mass (called the "inverted pendulum" mechanism).
The total mechanical work (Wtot =Wext + Wint) produced by a body during activity.
These outcomes are measured by composite for:(external, internal mechanical work, in Joules).
This outcome will be measured through the registered image movement analysis using the three-dimensional motion analysis system VICON of the walking test on the treadmill.
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Change from baseline at 12 weeks.
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Parameters of Pendular Mechanism: Recovery
Time Frame: Change from baseline at 12 weeks.
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The mechanical energy exchange of the center of mass is quantified by the calculation of the percentage of reconversion of mechanical energy, called Recovery (R), which counts the form that the mechanical energy is saved through the pendulum mechanism of the locomotion.
This outcome will be measured through the registered image movement analysis using the three-dimensional motion analysis system VICON of the walking test on the treadmill.
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Change from baseline at 12 weeks.
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Motor behavior by electromyographic activity
Time Frame: Change from baseline at 12 weeks.
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During the gait initiation, sit-to-stand movement and go up and down one step, the investigators will evaluate the anticipatory postural adjustments and compensatory postural adjustments. The electromyograph will be used to obtain electromyographic activity data of the spinal erector muscles, internal oblique, gluteus medius, rectus femoris, femoral biceps, medial gastrocnemius and tibialis anterior (in mV). All these parameters will be measured before and after Nordic walking, dance and jogging interventions. |
Change from baseline at 12 weeks.
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Muscular activation
Time Frame: Change from baseline at 12 weeks.
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Muscular activation during phases of the gait cycle of people with Parkinson's disease through the electromyographic evaluation of the muscles of the spinal erector, internal oblique, gluteus medius, rectus femoris, femoral biceps, anterior tibialis and medial gastrocnemius during treadmill running.
All participants will walk on a treadmill at selected walking speed.
To identify electromyographic activity during the different gait cycles, the electromyograph will be synchronized with VICON (Vicon Motion Capture System - Oxford - USA, 1984).
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Change from baseline at 12 weeks.
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Scapular and pelvis coordination parameters
Time Frame: Change from baseline at 12 weeks.
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The scapular girdle movement in angles will be measure, pelvic girdle in angles will be measure. The scapular girdle movement in angles will be aggregated to pelvic girdle in angles to arrive at continuous and discrete phases coordinations in angles. All these parameters will be measure before and after the nordic walking, dance and jogging aquatic interventions. |
Change from baseline at 12 weeks.
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Angular variables
Time Frame: Change from baseline at 12 weeks.
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Tilt pelvic in angle, flexion and extension of trunk in angle, flexion and extension of hip in angle, flexion and extension of knee in angle, flexion and extension of ankle in angle, flexion and extension of shoulder in angle, abduction of shoulder in angle, flexion and extension of elbow in angle. All these angles variables will be measure in right and left limbs. Flexion and extension of shoulder in angle, abduction of shoulder in angle will be aggregated to flexion and extension of elbow in angle to arrive at asymmetry of upper limbs in angles.
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Change from baseline at 12 weeks.
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Body Composition - Bone mineral density.
Time Frame: Change from baseline at 12 weeks.
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The body composition of the patient will be analyzed using the dual-energy X-ray absorptiometry (DEXA - Lunar Prodigy GE model Medical System, Milwaukee, WI, USA). The patient will be lying down in the 10 to 12 minutes until the test is complete. To prevent the movement of the lower limbs during passage of the reading rod of the velcro around the ankles and thighs. The patient can wear normal clothes as long as they have no metal charges or attachments. |
Change from baseline at 12 weeks.
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Psychological parameters - Profile of Mood State
Time Frame: Change from baseline at 12 weeks.
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Profile of Mood States: This variable will be measure by the Brunel Mood Scale (BRUMS) that was developed to provide a quick assessment of mood states adult populations.
The BRUMS has been demonstrated to have Cronbach alpha values above 0.70 and is a reliable tool used to measure the mood of Brazilian athletes.
The instrument consisted of 24 items and six subscales assessing mood: tension, depression, anger, vigor, fatigue and confusion.
Each item was rated on a Likert scale ranging from nothing (0) to extremely (4), where the respondent indicated how they were feeling at that moment.
The results were calculated using the mean of the items in each subscale.
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Change from baseline at 12 weeks.
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Quality of sleep - The Pittsburgh Sleep Quality Index
Time Frame: Change from baseline at 12 weeks.
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The Pittsburgh Sleep Quality Index (PSQI).
The PSQI consists of 24 questions or items to be rated (0-3 for 20 items while 4 items are open-ended), 19 of which are self-reported and 5 of which require secondary feedback from a room or bed partner.
Only the self-reported items (15 rated as 0-3 while 4 open-ended) are used for quantitative evaluation of sleep quality as perceived by the patient.
The open-ended items are also finally scored as structured categorical values (rated at 0-3) as per the range of values reported for them by the patient.
These 19 self-reported items are used to generate categorical scores representing the PSQI's 7 components.
The individual component scores each assess a specific feature of sleep.
Finally, the scores for each component are summed to get a total score, also termed the global score (range: 0 to 21).
This score provides a summary of the respondent's sleep experience and quality for the past month.
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Change from baseline at 12 weeks.
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Nominal verbal fluency
Time Frame: Change from baseline at 12 weeks.
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Nominal verbal fluency evaluates verbal fluency, executive function, language, and semantic memory.
The test consists in naming the largest number of words beginning with the letters "F", "A" and "S" in one minute each, excluding proper names.
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Change from baseline at 12 weeks.
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Collaborators and Investigators
Investigators
- Study Director: Leonardo Alexandre Peyré-Tartaruga, PhD, Federal University of Rio Grande do Sul
Publications and helpful links
General Publications
- Podsiadlo D, Richardson S. The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991 Feb;39(2):142-8. doi: 10.1111/j.1532-5415.1991.tb01616.x.
- Hackney ME, Kantorovich S, Levin R, Earhart GM. Effects of tango on functional mobility in Parkinson's disease: a preliminary study. J Neurol Phys Ther. 2007 Dec;31(4):173-9. doi: 10.1097/NPT.0b013e31815ce78b.
- Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology. 1967 May;17(5):427-42. doi: 10.1212/wnl.17.5.427. No abstract available.
- Frazzitta G, Balbi P, Maestri R, Bertotti G, Boveri N, Pezzoli G. The beneficial role of intensive exercise on Parkinson disease progression. Am J Phys Med Rehabil. 2013 Jun;92(6):523-32. doi: 10.1097/PHM.0b013e31828cd254.
- Alberts JL, Linder SM, Penko AL, Lowe MJ, Phillips M. It is not about the bike, it is about the pedaling: forced exercise and Parkinson's disease. Exerc Sport Sci Rev. 2011 Oct;39(4):177-86. doi: 10.1097/JES.0b013e31822cc71a.
- Cavagna GA, Willems PA, Legramandi MA, Heglund NC. Pendular energy transduction within the step in human walking. J Exp Biol. 2002 Nov;205(Pt 21):3413-22. doi: 10.1242/jeb.205.21.3413.
- Cho C, Kunin M, Kudo K, Osaki Y, Olanow CW, Cohen B, Raphan T. Frequency-velocity mismatch: a fundamental abnormality in parkinsonian gait. J Neurophysiol. 2010 Mar;103(3):1478-89. doi: 10.1152/jn.00664.2009. Epub 2009 Dec 30.
- Dereli EE, Yaliman A. Comparison of the effects of a physiotherapist-supervised exercise programme and a self-supervised exercise programme on quality of life in patients with Parkinson's disease. Clin Rehabil. 2010 Apr;24(4):352-62. doi: 10.1177/0269215509358933.
- Detrembleur C, van den Hecke A, Dierick F. Motion of the body centre of gravity as a summary indicator of the mechanics of human pathological gait. Gait Posture. 2000 Dec;12(3):243-50. doi: 10.1016/s0966-6362(00)00081-3.
- Farris DJ, Hampton A, Lewek MD, Sawicki GS. Revisiting the mechanics and energetics of walking in individuals with chronic hemiparesis following stroke: from individual limbs to lower limb joints. J Neuroeng Rehabil. 2015 Feb 27;12:24. doi: 10.1186/s12984-015-0012-x.
- Franchignoni F, Horak F, Godi M, Nardone A, Giordano A. Using psychometric techniques to improve the Balance Evaluation Systems Test: the mini-BESTest. J Rehabil Med. 2010 Apr;42(4):323-31. doi: 10.2340/16501977-0537.
- Gallo PM, McIsaac TL, Garber CE. Walking economy during cued versus non-cued self-selected treadmill walking in persons with Parkinson's disease. J Parkinsons Dis. 2014;4(4):705-16. doi: 10.3233/JPD-140445.
- Gomenuka NA, Bona RL, da Rosa RG, Peyre-Tartaruga LA. The pendular mechanism does not determine the optimal speed of loaded walking on gradients. Hum Mov Sci. 2016 Jun;47:175-185. doi: 10.1016/j.humov.2016.03.008. Epub 2016 Mar 24.
- Hausdorff JM, Schaafsma JD, Balash Y, Bartels AL, Gurevich T, Giladi N. Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait. Exp Brain Res. 2003 Mar;149(2):187-94. doi: 10.1007/s00221-002-1354-8. Epub 2003 Jan 22.
- Herman T, Giladi N, Gruendlinger L, Hausdorff JM. Six weeks of intensive treadmill training improves gait and quality of life in patients with Parkinson's disease: a pilot study. Arch Phys Med Rehabil. 2007 Sep;88(9):1154-8. doi: 10.1016/j.apmr.2007.05.015.
- Jankovic J. Parkinson's disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008 Apr;79(4):368-76. doi: 10.1136/jnnp.2007.131045.
- Kuo AD, Donelan JM. Dynamic principles of gait and their clinical implications. Phys Ther. 2010 Feb;90(2):157-74. doi: 10.2522/ptj.20090125. Epub 2009 Dec 18.
- Merello M, Fantacone N, Balej J. Kinematic study of whole body center of mass position during gait in Parkinson's disease patients with and without festination. Mov Disord. 2010 Apr 30;25(6):747-54. doi: 10.1002/mds.22958.
- MONTEIRO, E.P et al. Aspectos biomecânicos da locomoção de pessoas com doença de Parkinson: revisão narrativa. Revista Brasileira de Ciências do Esporte, ago. 2016. doi.org/10.1016/j.rbce.2016.07.003
- Monteiro EP, Franzoni LT, Cubillos DM, de Oliveira Fagundes A, Carvalho AR, Oliveira HB, Pantoja PD, Schuch FB, Rieder CR, Martinez FG, Peyre-Tartaruga LA. Effects of Nordic walking training on functional parameters in Parkinson's disease: a randomized controlled clinical trial. Scand J Med Sci Sports. 2017 Mar;27(3):351-358. doi: 10.1111/sms.12652. Epub 2016 Feb 2.
- Morris M, Iansek R, McGinley J, Matyas T, Huxham F. Three-dimensional gait biomechanics in Parkinson's disease: evidence for a centrally mediated amplitude regulation disorder. Mov Disord. 2005 Jan;20(1):40-50. doi: 10.1002/mds.20278.
- PEYRÉ-TARTARUGA, L.A; MONTEIRO, E.P. PERSPECTIVE: A new integrative approach to evaluate pathological gait: locomotor rehabilitation index. Clinical Trials in Degenerative Diseases, jul. 2016. v. 1, n. 2, p. 86-90.
- Reuter I, Mehnert S, Leone P, Kaps M, Oechsner M, Engelhardt M. Effects of a flexibility and relaxation programme, walking, and nordic walking on Parkinson's disease. J Aging Res. 2011;2011:232473. doi: 10.4061/2011/232473. Epub 2011 Mar 30.
- Saibene F, Minetti AE. Biomechanical and physiological aspects of legged locomotion in humans. Eur J Appl Physiol. 2003 Jan;88(4-5):297-316. doi: 10.1007/s00421-002-0654-9. Epub 2002 Nov 13.
- Schepens B, Bastien GJ, Heglund NC, Willems PA. Mechanical work and muscular efficiency in walking children. J Exp Biol. 2004 Feb;207(Pt 4):587-96.
- Sharp K, Hewitt J. Dance as an intervention for people with Parkinson's disease: a systematic review and meta-analysis. Neurosci Biobehav Rev. 2014 Nov;47:445-56. doi: 10.1016/j.neubiorev.2014.09.009. Epub 2014 Sep 28.
- Shine JM, Moore ST, Bolitho SJ, Morris TR, Dilda V, Naismith SL, Lewis SJ. Assessing the utility of Freezing of Gait Questionnaires in Parkinson's Disease. Parkinsonism Relat Disord. 2012 Jan;18(1):25-9. doi: 10.1016/j.parkreldis.2011.08.002. Epub 2011 Aug 26.
- SOARES, G.S.; PEYRÉ-TARTARUGA, L.A. Doença de Parkinson e exercício físico: uma revisão de literatura. Ciência em Movimento, 2010. v. 24, p. 69-86.
- Tuon T, Valvassori SS, Dal Pont GC, Paganini CS, Pozzi BG, Luciano TF, Souza PS, Quevedo J, Souza CT, Pinho RA. Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease. Brain Res Bull. 2014 Sep;108:106-12. doi: 10.1016/j.brainresbull.2014.09.006. Epub 2014 Sep 28.
- Wild LB, de Lima DB, Balardin JB, Rizzi L, Giacobbo BL, Oliveira HB, de Lima Argimon II, Peyre-Tartaruga LA, Rieder CR, Bromberg E. Characterization of cognitive and motor performance during dual-tasking in healthy older adults and patients with Parkinson's disease. J Neurol. 2013 Feb;260(2):580-9. doi: 10.1007/s00415-012-6683-3. Epub 2012 Sep 29.
- Willems PA, Cavagna GA, Heglund NC. External, internal and total work in human locomotion. J Exp Biol. 1995 Feb;198(Pt 2):379-93. doi: 10.1242/jeb.198.2.379.
- Zigmond MJ, Smeyne RJ. Exercise: is it a neuroprotective and if so, how does it work? Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S123-7. doi: 10.1016/S1353-8020(13)70030-0.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- LTartaruga,PPT-Parkinson
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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