Krill Oil and Muscle in Older Adults

November 2, 2020 updated by: Stuart Gray, University of Glasgow

Effects of Krill Oil Supplementation on Muscle Function in Older Adults

The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

102

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

65 years and older (OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • BMI less than 35kg/m2

Exclusion Criteria:

  • Diabetes
  • severe cardiovascular disease
  • seizure disorders
  • uncontrolled hypertension (>150/90mmHg at baseline measurement)
  • cancer or cancer that has been in remission <5 years
  • ambulatory impairments which would limit ability to perform assessments of muscle function
  • dementia
  • taking medication known to affect muscle (e.g. steroids)
  • have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
  • on anticoagulant therapy
  • allergies to seafood
  • regular consumption of more than 2 portions of oily fish per week.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: TRIPLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
PLACEBO_COMPARATOR: Placebo
4g/day of mixed vegetable oil supplements
Dietary supplement: Placebo
Mixed vegetable oil
EXPERIMENTAL: Krill
4g/day krill oil
Dietary supplement: Krill Oil
Aker Biomarine Superba Krill Oil

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Muscle strength
Time Frame: Change from baseline to 6 months
knee extensor muscle strength
Change from baseline to 6 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Grip strength
Time Frame: Change from baseline to 6 months
Grip strength
Change from baseline to 6 months
Change in Muscle thickness
Time Frame: Change from baseline to 6 months
Vastus lateralis muscle thickness
Change from baseline to 6 months
Change in Short performance physical battery test
Time Frame: Change from baseline to 6 months
SPPB
Change from baseline to 6 months
Change in Body Fat
Time Frame: Change from baseline to 6 months
Measured by BIA
Change from baseline to 6 months
Change in Lean Mass
Time Frame: Change from baseline to 6 months
Measured by BIA
Change from baseline to 6 months
Change in Fasting glucose
Time Frame: Change from baseline to 6 months
Fasting glucose
Change from baseline to 6 months
Change in Blood lipids
Time Frame: Change from baseline to 6 months
Blood lipids
Change from baseline to 6 months
Change in CRP
Time Frame: Change from baseline to 6 months
CRP
Change from baseline to 6 months
Change in Erythrocyte fatty acid profile
Time Frame: Change from baseline to 6 months
Erythrocyte fatty acid profile
Change from baseline to 6 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Glasgow

Investigators

  • Principal Investigator: Stuart Gray, PhD, University of Glasgow

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

March 7, 2018

Primary Completion (ACTUAL)

March 10, 2020

Study Completion (ACTUAL)

March 10, 2020

Study Registration Dates

First Submitted

July 26, 2019

First Submitted That Met QC Criteria

August 5, 2019

First Posted (ACTUAL)

August 7, 2019

Study Record Updates

Last Update Posted (ACTUAL)

November 3, 2020

Last Update Submitted That Met QC Criteria

November 2, 2020

Last Verified

November 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 200170067

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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