Veterans Response to Dosage in Chiropractic Therapy (VERDICT)

VERDICT (Veterans Response to Dosage in Chiropractic Therapy): A Pragmatic Randomized Trial Addressing Dose Effects for Chronic Low Back Pain

This study evaluates how Veterans with chronic low back pain (cLBP) respond to varying doses of chiropractic therapy and how health services utilization are impacted as a result.

There are 2 phases in this study. In Phase 1, half of participants will receive a low dose (1-5 visits) of chiropractic care for 10 weeks, while the other half will receive a higher dose (8-12 visits) for 10 weeks. At the end of Phase 1, participants in each group will be randomized again to receive either chronic chiropractic pain management (CCPM) (1 scheduled chiropractic visit per month x 10 months) or no CCPM for 10 months.

Study Overview

• Status: Recruiting
• Conditions: Low Back Pain; Patient Acceptance of Health Care; Veterans Health
• Intervention / Treatment: Other: Chiropractic Care

Detailed Description

The combination of chronic low back pain (cLBP) and high medication use negatively impacts Veterans' work productivity and quality of life, and generates substantial risk for long-term disability and opioid addiction. Although non-pharmacological therapies, such as those commonly used by doctors of chiropractic (DCs), are recommended by recent guidelines for treatment of cLBP, the optimal patterns of chiropractic use, clinical impact of chiropractic treatment on other health services utilization, and long-term effectiveness of chiropractic care is unknown.

This is a pragmatic, parallel groups, multisite randomized trial. Veterans with cLBP are randomly allocated to undergo a course of a low dose (1-5 visits) or a higher dose (8-12 visits) of multimodal, evidence-based chiropractic care for 10 weeks (Phase 1). The investigators hypothesize that a higher dose (8-12 visits) of chiropractic care will be more effective in improving function and reducing pain intensity and pain-related interference in Veterans with cLBP compared to a low dose (1-5 visits).

After Phase 1, participants within each treatment arm will be randomly allocated again to receive either chronic chiropractic pain management (CCPM) consisting of scheduled monthly chiropractic care or no CCPM for 10 months. The investigators hypothesize that CCPM (1 scheduled chiropractic visit per month x 10 months) will result in improved function, and reduced pain intensity, pain-related interference, and average number of days per week with low back pain (LBP) in Veterans with cLBP compared to no CCPM.

This study will also evaluate the impact of CCPM on health services outcomes compared to no CCPM. Evaluation of health services utilization at 52 weeks will include use of prescription medications, including opioids, referrals and number of visits to other healthcare professionals or service lines (physical therapy, injections, surgery, etc.), and hospitalizations for any cause and for cLBP.

Finally, the investigators will evaluate patient and clinician perceptions of non-specific treatment factors, effectiveness of study interventions, and impact of the varying doses of standard chiropractic care and the CCPM on clinical outcomes across 4 VA facilities using a mixed method, process evaluation approach.

• Study Type: Interventional
• Enrollment (Estimated): 766
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Anna Cobb, DC, MS; Phone Number: 563-884-5162; Email: anna.waldencobb@palmer.edu
• Study Contact Backup: Name: Cynthia Long, PhD; Phone Number: 563-884-5157; Email: long_c@palmer.edu

Study Locations

• United States
  • California
    • Los Angeles, California, United States, 90073
      • Recruiting
      • VA Greater Los Angeles Health Care System
      • Contact: Paul Shekelle, MD, PhD; Phone Number: 310-478-3711; Email: paul.shekelle@va.gov
      • Contact: Mel Valle; Phone Number: 563-594-9386; Email: melvin.valle-amaya@va.gov
  • Connecticut
    • West Haven, Connecticut, United States, 06516
      • Recruiting
      • VA Connecticut Healthcare System
      • Contact: Anthony Lisi, DC; Phone Number: 5341 203-932-5711; Email: anthony.lisi@va.gov
      • Contact: Kena McDermott, DC; Phone Number: 475-414-1476; Email: kena.mcdermott@va.gov
  • Iowa
    • Iowa City, Iowa, United States, 52246
      • Recruiting
      • Iowa City VA Health Care System
      • Contact: Anna L Cobb, DC, MS; Phone Number: 563-949-0676; Email: anna.waldencobb@palmer.edu
      • Contact: Elissa Twist, DC, MS; Phone Number: 563-884-5891
  • Minnesota
    • Minneapolis, Minnesota, United States, 55417
      • Recruiting
      • Minneapolis VA Health Care System
      • Contact: Richard Branson, DC; Phone Number: 612-467-5336; Email: richard.branson@va.gov
      • Contact: Rebecca Rudquist; Phone Number: 612-806-3776; Email: rebecca.rudquist@va.gov

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Veterans aged ≥ 18 years
• Self-reported cLBP
• Has low back related pain and disability
• Able to comprehend study details without need for a proxy
• Diagnostic confirmation of neuromusculoskeletal LBP
• Willing and able to attend up to 1 year of outpatient chiropractic visits

Exclusion Criteria:

• Any condition prohibiting or contraindicating chiropractic care
• Inability to complete outcomes and/or provide informed consent as determined by the site SC during the consent process
• Established plans to move within 3 months
• Under active chiropractic care
• No phone
• No email address
• Participating in another study investigating treatment(s) for pain
• Current or planned hospice care
• Current or planned pregnancy

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Phase 1: Low Dose (1-5 visits); Veterans with cLBP who will be randomly allocated to undergo a course of a low dose (1-5 visits) of multimodal, evidence-based chiropractic care for 10 weeks (Phase 1).	Other: Chiropractic Care; Chiropractic interventions: Patient education.; Passive interventions, such as spinal manipulation and myofascial therapies which include thrust type (high velocity-low amplitude) spinal manipulation for the low back, non-thrust manipulation (joint mobilization), and use of manually held instruments, such as an Activator. Myofascial therapies are also commonly used, such as myofascial release and trigger point therapy.; Transitional interventions, such as therapeutic exercise.; Recommendations for active interventions, such as general exercise and mind-body therapies.; Self-management advice, which refers to advice given to build the capacity of a person to self-monitor, control, and/or reduce the impact of a condition over time.; Other Names: Manipulation, Chiropractic
Active Comparator: Phase 1: Higher Dose (8-12 visits); Veterans with cLBP who will be randomly allocated to undergo a course of a higher dose (8-12 visits) of multimodal, evidence-based chiropractic care for 10 weeks (Phase 1).	Other: Chiropractic Care; Chiropractic interventions: Patient education.; Passive interventions, such as spinal manipulation and myofascial therapies which include thrust type (high velocity-low amplitude) spinal manipulation for the low back, non-thrust manipulation (joint mobilization), and use of manually held instruments, such as an Activator. Myofascial therapies are also commonly used, such as myofascial release and trigger point therapy.; Transitional interventions, such as therapeutic exercise.; Recommendations for active interventions, such as general exercise and mind-body therapies.; Self-management advice, which refers to advice given to build the capacity of a person to self-monitor, control, and/or reduce the impact of a condition over time.; Other Names: Manipulation, Chiropractic
Active Comparator: Phase 2: CCPM; After Phase 1, Veterans with cLBP who will be randomly allocated again to receive chiropractic chronic pain management (CCPM) consisting of scheduled monthly chiropractic care for 10 months.	Other: Chiropractic Care; Chiropractic interventions: Patient education.; Passive interventions, such as spinal manipulation and myofascial therapies which include thrust type (high velocity-low amplitude) spinal manipulation for the low back, non-thrust manipulation (joint mobilization), and use of manually held instruments, such as an Activator. Myofascial therapies are also commonly used, such as myofascial release and trigger point therapy.; Transitional interventions, such as therapeutic exercise.; Recommendations for active interventions, such as general exercise and mind-body therapies.; Self-management advice, which refers to advice given to build the capacity of a person to self-monitor, control, and/or reduce the impact of a condition over time.; Other Names: Manipulation, Chiropractic
No Intervention: Phase 2: No CCPM; After Phase 1, Veterans with cLBP who will be randomly allocated again to receive no CCPM in which they will receive no chiropractic care for 10 months.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from Baseline Low Back Pain Disability at several time points - Roland Morris Disability Questionnaire (RMDQ)	A one-page, 24-item questionnaire related to low back pain disability. The RMDQ can discriminate between different forms of treatment for back pain, and is sensitive to clinical change.	At Baseline and Weeks 5, 10, 26, 40, and 52

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Healthcare Services Utilization	We will assess all healthcare services used by each participant during the study period including the clinics seen, number of visits, orders, investigations, and prescriptions. We will estimate costs for these services using Decision Support System69 data. We will assess differences in cLBP-related healthcare utilization in the 4 treatment groups (low dose-CCPM, low dose-no CCPM, higher dose-CCPM, higher dose-no CCPM). In addition, we will investigate differences in health care utilization between sites.	52 weeks

Collaborators and Investigators

• Sponsor: Palmer College of Chiropractic
• Collaborators: Yale University; Minneapolis Veterans Affairs Medical Center; University of Iowa; Duke University; VA Connecticut Healthcare System; National Center for Complementary and Integrative Health (NCCIH); Dartmouth College; VA Greater Los Angeles Healthcare System; Iowa City VA Health Care System; Office of Research on Women's Health (ORWH)
• Investigators: Principal Investigator: Christine Goertz, DC, PhD, Duke University; Principal Investigator: Cynthia Long, PhD, Palmer Center for Chiropractic Research (PCCR)

Study record dates

Study Major Dates

• Study Start (Actual): February 23, 2021
• Primary Completion (Estimated): December 22, 2024
• Study Completion (Estimated): December 22, 2024

Study Registration Dates

• First Submitted: August 27, 2019
• First Submitted That Met QC Criteria: September 10, 2019
• First Posted (Actual): September 12, 2019

Study Record Updates

• Last Update Posted (Actual): August 21, 2023
• Last Update Submitted That Met QC Criteria: August 18, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Keywords: chronic; pain management; manipulation, chiropractic
• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Back Pain; Low Back Pain
• Other Study ID Numbers: 18-34; UH3AT009761 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Depending upon the needs and desires of the requesting party, the data that are shared may include analytic tables or de-identified, limited data sets that are transmitted to the requesting parties for additional analyses. In order to safeguard patient confidentiality and scientific integrity, the investigators will make the data and associated documentation available to users only under a data-sharing agreement that provides for: (1) evidence of local IRB approval from the requesting party's home institution; (2) a commitment to use the data only for research purposes and not to identify any individual participant; (3) a commitment to secure the data using appropriate computer technology to protect the privacy and security of the individual participant; (4) a commitment to destroy or return the data after analyses are completed; and (5) an assurance to use the data in compliance with all applicable statutes and regulations, including but not limited to the HIPAA.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No