- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06235671
Effects of Chiropractic on Chronic Cancer-related Fatigue (CAN)
The Effects of Upper Cervical Chiropractic Care in Adult Cancer Survivors With Chronic Cancer-related Fatigue: a Feasibility Trial
Study Overview
Status
Intervention / Treatment
Detailed Description
Cancer remission is often marked by the cessation of curative-intent treatments (e.g., surgery, chemotherapy, radiotherapy, immunotherapy), however, troublesome signs and symptoms (e.g., fatigue, depression, cognitive impairment, dysautonomia) related to the cancer and its treatments commonly persist for prolonged periods (i.e., months to years). Of these, chronic cancer-related fatigue (CCRF) is one of the most frequently reported and debilitating symptoms. CCRF may be characterized as tiredness or exhaustion persisting for 3 or more months following the completion of the primary curative-intent cancer therapies which is independent on one's quantity or quality of rest and causes impairments in daily functioning and quality of life. Notably, although the mechanisms underlying CCRF are still unclear, there is some evidence that it may be related to autonomic dysregulation.
Irrespective of the cause(s), lack of identification of and treatment for CCRF and other chronic cancer-related sequelae is commonplace. Further, empirical data supporting the efficacy of interventions to remediate these issues are relatively sparse and urgently needed as the global population of cancer survivors continues to increase. Of note, although there is no universally accepted definition of 'cancer survivor', the investigators define it here as someone who has completed their primary curative-intent therapies and is cancer-free (i.e., has no evidence of active disease). This definition is in line with that of the European Organisation of Research & Treatment of Cancer (EORTC) Survivorship Task Force and the EORTC Quality of Life Group.
Interestingly, a recent study suggested that a single chiropractic adjustment may mitigate lower extremity muscular fatigue during isometric exercise in young, healthy males. However, to the investigators' knowledge, the impact of chiropractic care on CCRF and other health-related challenges that burden cancer survivors has yet to be investigated.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Austin Garlinghouse
- Phone Number: 770-426-2639
- Email: research.studies@life.edu
Study Locations
-
-
Georgia
-
Atlanta, Georgia, United States, 30308
- Dr. Sid E. Williams Center for Chiropractic Research
-
Contact:
- Austin Garlinghouse
- Phone Number: 770-426-2639
- Email: research.studies@life.edu
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Able to understand and provide written informed consent in English
- 18-65 years of age
- Informed by primary health care provider that there is no evidence of active disease (this is sometimes referred to as "complete remission" or "cured")
- Minimum of 3 months since completion of primary curative-intent cancer therapies including surgery, chemotherapy, radiotherapy, and/or immunotherapy (long-term hormonal therapy permitted)
- Onset of fatigue occurred at some point during illness and/or treatment
- FACIT-Fatigue scale score in the moderate-to-severe range (i.e., at or above the 60th percentile)
- If on any prescription medication (including hormonal therapy), on a stable dose for a minimum of 12 weeks with no plans to change medications or doses during the study
Exclusion Criteria:
- Taking any short-acting benzodiazepine including midazolam & triazolam
- Known disorder resulting in syncope/fainting during postural changes (e.g., postural orthostatic tachycardia syndrome, orthostatic hypotension)
- Pacemaker or known heart condition that influences the electrical or mechanical function of the heart (e.g., severe heart valve disease)
- Diagnosed with an externalizing (e.g., substance use, antisocial disorder) or thought (e.g., schizophrenia, paranoid personality, bipolar) disorder that is uncontrolled or untreated
- Diagnosed with rheumatoid arthritis, osteoporosis, or cervical spine instability
- Currently pregnant
- Current litigation related to a physical, health-related injury
- Chronic pain rated at least 3/10 on a visual analog scale (VAS)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Chiropractic intervention
Upper cervical chiropractic care
|
6 weeks of chiropractic care
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Participant recruitment
Time Frame: 6-month data collection period
|
Average number of participants recruited/enrolled per month
|
6-month data collection period
|
Participant scheduling
Time Frame: 6-month data collection period
|
Average time lag between first lab assessment & first chiropractic visit
|
6-month data collection period
|
Participant compliance
Time Frame: 6-month data collection period
|
Proportion of participants violating 1 or more pre-assessment lifestyle restrictions & unable/unwilling to be rescheduled
|
6-month data collection period
|
Participant adherence
Time Frame: 6-month data collection period
|
Proportion of participants not attending at least 80% of their chiropractic sessions
|
6-month data collection period
|
Participant tolerability
Time Frame: 6-month data collection period
|
Proportion of participants unable/unwilling to complete a given assessment
|
6-month data collection period
|
Participant retention
Time Frame: 6-month data collection period
|
Proportion of participants completing the trial
|
6-month data collection period
|
Assessment acceptability
Time Frame: 6-month data collection period
|
Most common patient-related acceptability score for each assessment process/procedure
|
6-month data collection period
|
Data fidelity
Time Frame: 6-month data collection period
|
Proportion of acquisitions from a given assessment that are unsuitable for analysis
|
6-month data collection period
|
Implementation acceptability
Time Frame: 6-month data collection period
|
Most common clinician-rated acceptability score for each trial process/procedure
|
6-month data collection period
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Yori Gidron, PhD, University of Haifa
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- I-0029
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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