Posturography-Neuropathy (PONE)

Study of Gait and Posture in Subacute Acquired Neuropathies and in Hereditary Neuropathies

If the classification between hereditary and acquired neuropathy is often easy, there is no completely specific marker allowing the distinction between the two etiologies. Clinical experience suggests that hereditary neuropathies have less impact on balance and gait than the acquired neuropathies at equivalent level of impairment, but this has never been clearly demonstrated.

Study Overview

• Status: Completed
• Conditions: Neuropathy Demyelinating
• Intervention / Treatment: Other: Motion analysis

• Study Type: Interventional
• Enrollment (Actual): 67
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Lille, France
    • Hôpital Roger Salengro, CHU

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• CMT1A for molecular-proven Group 1 (PMP22 duplication)
• IPDC likely or defined for Group 2
• Able to walk 10 m unassisted

Exclusion Criteria:

• Neurological history other than neuropathy: epilepsy, stroke, dementia
• Pregnant women
• Person under guardianship or trusteeship
• Musculoskeletal conditions other than neuropathy impairing walking abilities
• Major comorbidity considered a contraindication by the investigator (cancer, unstable angor, etc.)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: demyelinating hereditary neuropathy; adult patients with demyelinating hereditary neuropathy type CMT 1A.	Other: Motion analysis; Gait and posture recording
Experimental: demyelinating inflammatory neuropathy; adult patients with acquired demyelinating inflammatory neuropathy.	Other: Motion analysis; Gait and posture recording

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Posturography (Romberg's quotient)	Time 0 ; single session

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The Timed Up and Go test (TUG)	It uses the time that a person takes to rise from a chair, walk three meters, turn around, walk back to the chair, and sit down. the scores of ten seconds or less indicate normal mobility, 11-20 seconds are within normal limits for frail elderly and disabled patients, and greater than 20 seconds means the person needs assistance outside and indicates further examination and intervention. A score of 30 seconds or more suggests that the person may be prone to falls	Time 0 ; single session
stride length (in millimeters) parameters	Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)	Time 0 ; single session
stride time (in seconde) parameters	Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)	Time 0 ; single session
velocity (meter/seconde) parameters	Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)	Time 0 ; single session
cadence (step/min) parameters	Kinematic and Kinetic parameters of the gait initiation and the stabilised gait using the optoelectronic system (VICON®)	Time 0 ; single session

Collaborators and Investigators

• Sponsor: University Hospital, Lille
• Investigators: Principal Investigator: Céline TARD, MD, University Hospital, Lille

Publications and helpful links

General Publications

• Dupont L, Defebvre L, Davion JB, Delval A, Tard C. Postural balance and visual dependence in patients with demyelinating neuropathies differ between acquired and hereditary etiologies. Rev Neurol (Paris). 2025 Jan-Feb;181(1-2):98-105. doi: 10.1016/j.neurol.2024.10.002. Epub 2024 Oct 28.

Study record dates

Study Major Dates

• Study Start (Actual): May 19, 2021
• Primary Completion (Actual): January 19, 2024
• Study Completion (Actual): January 19, 2024

Study Registration Dates

• First Submitted: August 14, 2019
• First Submitted That Met QC Criteria: November 5, 2019
• First Posted (Actual): November 6, 2019

Study Record Updates

• Last Update Posted (Actual): December 11, 2025
• Last Update Submitted That Met QC Criteria: December 4, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: Balance; Gait; Posture; Charcot-Marie-Tooth; Chronic inflammatory demyelinating polyneuropathy
• Additional Relevant MeSH Terms: Nervous System Diseases; Pathologic Processes; Neuromuscular Diseases; Chronic Disease; Disease Attributes; Genetic Diseases, Inborn; Autoimmune Diseases; Immune System Diseases; Peripheral Nervous System Diseases; Autoimmune Diseases of the Nervous System; Demyelinating Diseases; Neurodegenerative Diseases; Congenital Abnormalities; Heredodegenerative Disorders, Nervous System; Nervous System Malformations; Polyneuropathies; Polyradiculoneuropathy; Hereditary Sensory and Motor Neuropathy; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Pathological Conditions, Signs and Symptoms; Charcot-Marie-Tooth Disease; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
• Other Study ID Numbers: 2017_17; 2017-A02861-52 (Other Identifier: ID-RCB number, ANSM)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No