Study of Eye Movements as Markers of the Physiological, Cerebral and Cognitive State of Healthy Subjects (EyeProxy)

The goal of this study is the multimodal exploration via eyetracking, MRI and EEG data of ocular movements and the corresponding brain activation during ecologic visual stimulation in the healthy population.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Neuroimaging

Detailed Description

Cerebral activation following visual stimulation is explored using two neuroimaging techniques EEG and MRI while eye movements are recorded. Three experiments are performed: in MR scanner 1) functional localisation of specific areas: LOC, FFA, MT/V5, V1 and V2 and 2) a saccadic choice experiment; with EEG, replication of the experiments performed in the MR scanner and 3) an additional experiment of movement detection during the ocular saccades.

Thirty young volunteers (18-40 y old) are involved.

• Study Type: Interventional
• Enrollment (Actual): 45
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Grenoble, France, 38043
    • CHU Grenoble Alpes

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Normal vision or corrected to normal
• Social security affiliation
• Signed consent to participate
• No pregnancy fo women

Exclusion Criteria:

• Audition and motor troubles
• Incapable to decide (Persons mentioned in L1121-5,6 et 8 of public health code)
• Neurological disorders
• Pathology affecting oculomotor control
• MRI incompatibility

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Healthy Subjects; All healthy subject are gathered in one arm	Other: Neuroimaging; MR, EEG recordings

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Eye movement brain networks	Identification of the cerebral locus of ocular movement via MRI & EEG	24 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
OculoDB	Database repository of healthy population	24 months

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Collaborators: Grenoble Institut des Neurosciences; GIPSA-LAB
• Investigators: Principal Investigator: Sara MEONI, PH, University Hospital, Grenoble

Study record dates

Study Major Dates

• Study Start (Actual): September 16, 2020
• Primary Completion (Actual): July 22, 2021
• Study Completion (Actual): July 22, 2021

Study Registration Dates

• First Submitted: March 25, 2020
• First Submitted That Met QC Criteria: March 27, 2020
• First Posted (Actual): March 30, 2020

Study Record Updates

• Last Update Posted (Actual): May 9, 2022
• Last Update Submitted That Met QC Criteria: May 6, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: 38RC20.063

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No