Level of Middle Cranial Fossa Dura in Patients With Cholesteatoma

Evaluation of the Level of Middle Cranial Fossa Dura in Patients With Cholesteatoma

Sponsors

Lead Sponsor: Assiut University

Source Assiut University
Brief Summary

Cholesteatoma is a destructive lesion that progressively expands in the middle ear, mastoid or petrous bone and leads to destruction of the nearby structures. Erosion, which is caused by bone resorption of the ossicular chain and otic capsule, may cause hearing loss, vestibular dysfunction, facial paralysis and intracranial manifestations

Detailed Description

Cholesteatoma has three Classical forms: (1) Congenital, primary or genuine cholesteatoma: occurs behind an intact tympanic membrane. Primary acquired cholesteatoma: looks like a limited diverticulum of the pars flaccida with little or no history of otorrhea. Secondary acquired cholesteatoma: develops with posterosuperior perforations in eardrum and expansion of the disease process into the antrum, mastoid, attic and middle ear. Granulation tissue, polyps and foul- smelling otorrhea are common findings in this type

Overall Status Not yet recruiting
Start Date October 1, 2020
Completion Date October 1, 2022
Primary Completion Date October 1, 2021
Study Type Observational
Primary Outcome
Measure Time Frame
Evaluation of the Level of Middle Cranial Fossa Dura in Patients with Cholesteatoma by multislice computed tomography. One year
Enrollment 80
Condition
Intervention

Intervention Type: Radiation

Intervention Name: Multislice computed tomography temporal bone

Description: Patients with cholesteatoma will undergo multislice computed tomography (MSCT) temporal bone images. Then The Tegmen level will be determined and compared with the other normal ear at the same patient

Arm Group Label: Patients with cholesteatoma

Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria: - All adults above the age of 18 presented to the Assiut university Clinic with cholesteatoma will be included in the study. Exclusion Criteria: 1. Patients with previous mastoid surgery 2. Patients with Craniofacial anomalies or cleft lip and palate 3. Pediatric populations ≤ 18 years old 4. Patients with congenital ear anomalies

Gender: All

Minimum Age: 18 Years

Maximum Age: N/A

Healthy Volunteers: No

Verification Date

September 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Assiut University

Investigator Full Name: Mariam Zakaria

Investigator Title: Principal investigator

Has Expanded Access No
Condition Browse
Arm Group

Label: Patients with cholesteatoma

Description: Patients with cholesteatoma in one ear that will compared with the other healthy one.

Study Design Info

Observational Model: Case-Control

Time Perspective: Cross-Sectional

Source: ClinicalTrials.gov