- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05387850
Clinical Frailty Assessment and Postoperative Adverse Outcomes and Quality of Life in Elderly Patients
Association of Clinical Frailty Assessment With Adverse Postoperative Outcomes and Quality of Life in Elderly Non-cardiac Surgery Patients: a Prospective Study
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
As the population aging is speeding up, senile diseases have become a significant and severe public health problem, influencing national health. More than 20 million elderly patients undergo surgery each year in China, accounting for a quarter of the population who undergo surgery. Advanced age and comorbid diseases render the elderly at increased risk of postoperative morbidity and mortality. The incidence of postoperative complications is twice as non-elderly patients, and mortality rates are five times higher than non elderly patients. Thus, it is a significant challenge to safely and stably ensure the elderly in an optimal perioperative period.
Elderly patients continue to pose a major threat to the world's rapidly ageing population due to high rates of surgery and postoperative complications in elderly patients. Therefore, optimizing perioperative management strategies for elderly patients remains one of the biggest challenges facing clinicians.
Frailty is a multidimensional clinical syndrome characterized by vulnerability to dependence and increased mortality when exposed to stressors. It is often clinically described as a lack of physiological reserve, manifested as a loss of physical ability, metabolic function, and cognitive abilities. A systematic review of studies of patients in general surgery reported that the prevalence of prefrailty was estimated to be between 11.3% and 45.8%, while the prevalence of frailty was estimated to be between 10.4% and 37.0%.
Although clinicians or relatives may be aware of frailty, there is currently no standardized clinical gold-standard assessment tool to widely use and quantify frailty.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
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Beijing
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Beijing, Beijing, China, 100853
- Chinese PLA General Hospital
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Geriatric surgical patients ≥65 years old
- non-selective cardiac surgery
Exclusion Criteria:
- Missing or incomplete patient follow-up records
- ASA degree V
- Delirium before surgery
- Patient refused to enroll
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Elderly patients over the age of 65
Elderly patients over the age of 65 undergoing elective non-cardiac surgery
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no intervention
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
mortality
Time Frame: up to 1 month
|
postoperative all-cause mortality
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up to 1 month
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
the incidence of postoperative delirium
Time Frame: During hospitalization (up to 1 month)
|
the incidence of postoperative delirium (3D-CAM scale).Delirium was defined as acute, transient, fluctuating, and usually reversible disturbances in attention, cognition, or attention level.
It was assessed every 12 hours by trained nurses using the confusion assessment method (CAM).
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During hospitalization (up to 1 month)
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postoperative sleep quality
Time Frame: 6 months after surgery
|
The PSQI measures sleep quality retrospectively over the previous month using self-report/recall; it consists of nineteen individual items which evaluate the seven components of sleep quality: (1) sleep duration; (2) sleep disturbance; (3) sleep latency; (4) daytime dysfunction due to sleepiness; (5) sleep efficiency; (6) overall sleep quality; and (7) sleep medication usageThese seven component scores (scored 0-3) are added together to yield one global score between 0-21, with higher scores indicating worse sleep quality .
A global PSQI score ≤5 indicates good sleep quality and >5 indicates poor sleep quality.
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6 months after surgery
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anxiety state and postoperative depression state
Time Frame: 12 months
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The GAD-7 asks how often people have suffered from the seven core symptoms of GAD within the last two weeks with the response options being 'not at all', 'on some days', 'on more than half of the days' and 'almost every day' (scored 0-3, with a total score ranging from 0 to 21) .
The GAD-7 has been validated within a large sample of patients in a primary care setting, and within a large general population sample in Germany.The higher the score, the worse the situation.
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12 months
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postoperative quality of life evaluation
Time Frame: 12 months
|
Patients'quality of life was assessed through telephone interviews 12 months after surgery using the EQ5D.
EQ5D is a measure of health status, assessing daily activities, including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression.
Each dimension consists of a 3-level response: no problems, moderate problems, or severe problems.
A scoring algorithm is available by which each health status description can be expressed as an overall score using the published Chinese tariffs for the Chinese population,12 ranging from 0 (death) to 1 (full health).
EQ5Dquestionnaires were acquired according to the script for telephone administration of the EQ5D5L simplified Chinese version for China through telephone interviews 12 months after surgery.
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12 months
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postoperative depression state (PHQ-9) Scale)
Time Frame: 12 months
|
Primary outcomes were depression (Patient Health Questionnaire 9 (PHQ-9)).Depression was evaluated using the Chinese version of the patient health questionnaire (PHQ-9), which has nine items measuring self-assessed depressive symptoms experienced during the previous 2 weeks.
It uses a 4-point Likert-type scale (0 = never, 1 = sometimes, 2 = more than once a week, and 3 = almost every day).
The total score ranges from 0 to 27, and higher scores indicate more depressive symptoms.
Scores of 10 and 15 represent cutpoints for moderate and moderately severe depression, respectively.
The Chinese version of the PHQ-9 has shown good psychometric properties with reported Cronbach's α of 0.86.
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12 months
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Study Chair: Mi Weidong, PhD, Chinese PLA hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PLAGH-Frailty-001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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