- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05714423
Outcomes in Lower Pole Kidney Stone Management Using Mini-PCNL Compared With Retrograde Intra Renal Surgery
January 26, 2023 updated by: Dr. SamiUllah, Services Hospital, Lahore
Outcomes in Lower Pole Kidney Stone Management Using Mini-PCNL Compared With Retrograde Intra Renal Surgery: A Randomized Controlled Trial
Due to the anatomic characteristics of the lower calyx, lower pole stones are difficult to be eliminated through the ureter, even if the stones had been fragmented.
Retrograde intrarenal surgery (RIRS) can be used to deal with lower pole stones of 1.0-2.0
cm, while percutaneous nephrolithotripsy (PCNL) is mainly used to deal with lower pole stones with larger diameter or when RIRS failed to resolve the stone.
This study was conducted to compare mini PCNL and retrograde intrarenal surgery (RIRS) for the management of lower pole kidney stones in terms of efficacy.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
150
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Punjab
-
Lahore, Punjab, Pakistan
- Shaikh Zayed Hospital Lahore
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Renal stone at lower pole of size 10mm -20mm
Exclusion Criteria:
- Patients with positive urine culture,
- Patients with anatomical abnormalities determined by ultrasonography
- Uncontrolled diabetes (HbA1c >9%)
- Patients undergone previous renal surgery
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: Mini-PCNL Group
In this group kidney stones will be treated with Mini-PCNL Surgery
|
Mini-PCNL will done as follows.
A 6 Fr ureteral catheter will be introduced through cystoscopy and dye will be instilled to opacify the pelvicalyceal system.
After elaborating the calyceal system through fluoroscopy, selective calyceal will be punctured and tract will be dilated using 16 F sheath.
Miniature nephroscope 14 Fr will be then introduced and stones will be fragmented by holmium: YAG laser.
Afterwards the collecting system will be examined through nephroscope and fluoroscopic confirmation will be done to ensure complete stone clearance.
In all the cases, 6 Fr 24 cm DJ stent will be placed and if remained uneventful, the patient will be discharged on postoperative day 2 with oral antibiotics.
|
ACTIVE_COMPARATOR: RIRS Group
In this group kidney stones will be treated with Retrograde Intrarenal Surgery.
|
RIRS will be performed as follows.
In this procedure a double J stent will be placed to dilate the calyceal system 2 weeks prior the surgery.
During the procedure, cystoscopy will be done, and 0.035-inch guide wire will be placed in the pelvi-calyceal system.
Ureteric access sheath of 12 Fr will be placed and with the help of digital polyscope the stone will be fragmented using Holmium: YAG laser using 220 μm fiber.
DJ stent 6F 24 cm will be placed in all the cases.
In uneventful surgery patient will be discharged on postoperative day 1 with oral antibiotics
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Stone Clearance
Time Frame: 4 weeks
|
Number of patients cleared from stones assessed by CT scan KUB
|
4 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Hospital Stay
Time Frame: 1 week
|
Hospital stay will be assessed in days
|
1 week
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
October 1, 2020
Primary Completion (ACTUAL)
November 30, 2022
Study Completion (ACTUAL)
December 31, 2022
Study Registration Dates
First Submitted
January 26, 2023
First Submitted That Met QC Criteria
January 26, 2023
First Posted (ACTUAL)
February 6, 2023
Study Record Updates
Last Update Posted (ACTUAL)
February 6, 2023
Last Update Submitted That Met QC Criteria
January 26, 2023
Last Verified
January 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- s12
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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