Exercise to Slow Cardiovascular Ageing Progression

May 10, 2023 updated by: National Heart Centre Singapore
In ageing, deleterious alterations in cardiovascular (CV) structure and function increase risks of ageing-related cardiovascular disease (CVD). Investigators found that these CV alterations were associated with circulating serum metabolites, suggesting a metabolic basis to CV ageing. Investigators hypothesize that modification of these metabolites by intervention, such as exercise, may retard CV alterations and reduce CVD in ageing.

Study Overview

Status

Recruiting

Conditions

Detailed Description

Participants from each stratum will be randomized to receive either an exercise program intervention or no exercise. At the start and end of study, participants will undergo cardiovascular imaging and metabolic profiling. Investigators will determine if exercise can reverse high-risk metabolic profiles and improve cardiovascular structure and function.

Without clear mechanisms to explain cardiovascular ageing nor interventions known to retard cardiovascular ageing, our approach will provide much needed translational evidence to incorporate targeted interventions aimed at reducing cardiovascular disease risk in older populations.

Study Type

Observational

Enrollment (Anticipated)

450

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Singapore
      • Singapore, Singapore, 169609
        • Recruiting
        • National Heart Centre Singapore
        • Contact:
        • Principal Investigator:
          • Angela Koh, M.D

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

21 years to 100 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Recruited through research studies and community studies.

Description

Inclusion Criteria:

  • Age >=21 years old
  • Outdoor ambulant

Exclusion Criteria:

  • Wheelchair or bed-bound
  • Dementia
  • Residing in sheltered or nursing home
  • Cancer
  • Participation in ongoing clinical trials that involve interventional drugs or devices
  • Aneurysms
  • Acute infections (in the last six months)
  • Uncontrolled thyrotoxicosis
  • Neuromuscular, musculoskeletal or rheumatoid disorders that are exacerbated by exercise
  • Uncontrolled asthma or chronic lung disease
  • Restrictive lung disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
A
  1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
  2. Bio-specimen collection
  3. Six-minute walk test
  4. Musculoskeletal Analysis
  5. Cardiopulmonary exercise test
B
  1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
  2. Bio-specimen collection
  3. Six-minute walk test
  4. Musculoskeletal Analysis
C
  1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
  2. Bio-specimen collection
  3. Six-minute walk test
  4. Musculoskeletal Analysis
D
  1. Cardiovascular measurements Non-invasive brachial blood pressure machine Echocardiography
  2. Bio-specimen collection
  3. Six-minute walk test (may require separate day visit to complete)
  4. Musculoskeletal Analysis
  5. Questionnaires

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Metabolite profiles
Time Frame: 12 Months
To measure changes in serum metabolite levels among participants pre and post exercise intervention.
12 Months
Cardiovascular structure and function
Time Frame: 12 Months
To measure changes in CV structure and function (diastolic function, arterial stiffness) among participants.
12 Months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Heart Centre Singapore

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2023

Primary Completion (Anticipated)

December 31, 2026

Study Completion (Anticipated)

December 31, 2051

Study Registration Dates

First Submitted

February 10, 2023

First Submitted That Met QC Criteria

March 7, 2023

First Posted (Actual)

March 20, 2023

Study Record Updates

Last Update Posted (Estimate)

May 11, 2023

Last Update Submitted That Met QC Criteria

May 10, 2023

Last Verified

May 1, 2023

More Information

Terms related to this study

Other Study ID Numbers

  • 2022/2667

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Exercise

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Dominican Republic

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe