- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05851027
Evaluating the Efficacy and Safety of QL0911 in Chemotherapy- Induced Thrombocytopenia
May 5, 2023 updated by: Qilu Pharmaceutical Co., Ltd.
A Multicenter, Randomized, Double Blind, Placebo Controlled Phase 3 Study Evaluating the Efficacy and Safety of Recombinant Human Thrombopoietin Mimetic Peptide-Fc Fusion Protein for Injection (QL0911) in Chemotherapy- Induced Thrombocytopenia
To evaluate the efficacy and safety of QL0911 in Chemotherapy- Induced Thrombocytopenia.
Thrombocytopenia is a low number of platelets in the blood.
Sometimes, thrombocytopenia is a side effect of chemotherapy.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
50
Phase
- Phase 2
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Shanghai
-
Shanghai, Shanghai, China, 200120
- Shanghai East Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- At least 18 years old when signing the informed consent form;
- Histopathological or cytological examination, confirmed as solid tumor or lymphoma (including NSCLC, breast cancer, bladder cancer, pancreatic cancer, etc.), the chemotherapy cycle is 21 days or 28 days, and one or more of the following chemotherapy drugs are needed: anti-metabolic drugs, including gemcitabine, etc.; Platinum, including carboplatin, nedaplatin, cisplatin, lobaplatin, etc. Anthracyclines, including adriamycin, daunorubicin, epirubicin, etc. Alkylating agent, including cyclophosphamide, ifosfamide, etc. Other cytotoxic chemotherapy drugs that can cause thrombocytopenia;
- In the last regular chemotherapy cycle, the subject had a decrease in platelet count below 75× 109/L;
- Platelet count ≤ 200× 109/L one day before chemotherapy;
- The estimated survival time at screening is ≥12 weeks, and the current chemotherapy regimen can be accepted for at least 2 cycles (at least 1 cycle in PartA);
- According to the score standard of physical fitness of the Eastern Cancer Cooperative Group (ECOG), it is 0-2;
- Fully understand and abide by the requirements of this study, and sign the informed consent form voluntarily.
Exclusion Criteria:
- Suffering from other hematopoietic diseases except lymphoma, including leukemia, primary immune thrombocytopenia, myeloproliferative diseases, multiple myeloma and myelodysplastic syndrome;
- Thrombocytopenia caused by non-tumor chemotherapy drugs occurred within 6 months before screening, including but not limited to EDTA-dependent pseudothrombocytopenia, hypersplenism, infection and bleeding;
- Bone marrow invasion or bone marrow metastasis occurs;
- Being receiving radiotherapy or having received abdominal or pelvic radiotherapy within 3 months;
- There have been any arterial or venous thrombosis events within 6 months before screening;
- Screening patients with severe cardiovascular disease (NYHA cardiac function score III-IV) and arrhythmia that increases the risk of thrombosis, such as atrial fibrillation, after coronary stent implantation, angioplasty and coronary artery bypass grafting;
- Clinical manifestations of severe bleeding (such as gastrointestinal bleeding, etc.) within 2 weeks before screening;
- Received platelet transfusion within 2 days before randomization;
- Patients have been treated with thrombopoietin receptor agonists (such as romistine and itrapoppa) or human recombinant thrombopoietin (rhTPO) or rhIL-11 within 4 weeks before the first administration;
- Anticoagulant drugs such as heparin, warfarin and aspirin have been used within 7 days before the first administration;
- Received bone marrow transplantation or stem cell infusion within one year before screening;
- Patients with chronic hepatitis B or hepatitis C in active period, and patients with positive antibodies to human immunodeficiency virus;
- The absolute value of neutrophils in the screening period is less than 1.5× 109/L, and hemoglobin is less than 90g/L;
- The total bilirubin in the screening period is more than 3 times the upper limit of the normal range; Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were higher than the upper limit of normal range by 3 times. For patients with liver metastasis, alanine aminotransferase (ALT) and aspartate aminotransferase (AST)≥ 5 times the upper limit of the normal range;
- Blood creatinine concentration ≥1.5ULN or EGFR ≤ 60 ml/min;
- patients with severe drug allergic reaction;
- Patients who have used any research drugs (excluding vitamins and minerals) within 3 months before the first administration;
- Patients who plan pregnancy, pregnancy or lactation;
- The researcher judges the patients who are not suitable for this experiment.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: QL0911 Group 1
Starting dose 1μg/kg;PLT 100~200×10^9/L
|
Qilu investigational product (QL0911 or placebo) will be administered in the clinic by a qualified healthcare provider as a subcutaneous injection.
|
Experimental: QL0911 Group 2
Starting dose 2μg/kg;PLT 100~200×10^9/L
|
Qilu investigational product (QL0911 or placebo) will be administered in the clinic by a qualified healthcare provider as a subcutaneous injection.
|
Experimental: QL0911 Group 3
Starting dose 2μg/kg;PLT <100×10^9/L
|
Qilu investigational product (QL0911 or placebo) will be administered in the clinic by a qualified healthcare provider as a subcutaneous injection.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
The effective response rate of QL0911 on the 21st day (21-days chemotherapy cycle) after administration.
Time Frame: 21 days
|
21 days
|
The effective response rate of QL0911 on the 28th day (28-days chemotherapy cycle) after administration.
Time Frame: 28 days
|
28 days
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes of platelet count from baseline in each visit(21-days chemotherapy cycle)
Time Frame: 21 days
|
21 days
|
Changes of platelet count from baseline in each visit(28-days chemotherapy cycle)
Time Frame: 28 days
|
28 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 15, 2021
Primary Completion (Actual)
September 10, 2021
Study Completion (Actual)
September 10, 2021
Study Registration Dates
First Submitted
April 23, 2023
First Submitted That Met QC Criteria
May 5, 2023
First Posted (Actual)
May 9, 2023
Study Record Updates
Last Update Posted (Actual)
May 9, 2023
Last Update Submitted That Met QC Criteria
May 5, 2023
Last Verified
April 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- QL0911-CIT-301(PartA)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Chemotherapy-induced Thrombocytopenia
-
Jiangsu HengRui Medicine Co., Ltd.Not yet recruitingChemotherapy-Induced Thrombocytopenia
-
Sobi, Inc.CompletedChemotherapy-induced ThrombocytopeniaUnited States, China, Hungary, Poland, Russian Federation, Serbia, Ukraine
-
Beijing Northland Biotech. Co., Ltd.CompletedChemotherapy-induced ThrombocytopeniaChina
-
BioMAS LtdTerminatedChemotherapy Induced ThrombocytopeniaIsrael
-
Qilu Pharmaceutical Co., Ltd.RecruitingChemotherapy-induced ThrombocytopeniaChina
-
Napolitano MariasantaRegione SiciliaTerminatedThrombocytopenia | Primary Thrombocytopenia,Unspecified | Thrombocytopenia Chemotherapy InducedItaly
-
Jiangsu HengRui Medicine Co., Ltd.Withdrawn
-
Jiangsu HengRui Medicine Co., Ltd.Active, not recruitingChemotherapy-Induced ThrombocytopeniaChina
-
Ono Pharma USA IncTerminatedChemotherapy-Induced ThrombocytopeniaUnited States, Korea, Republic of, Russian Federation
-
Institute of Hematology & Blood Diseases HospitalHenan Cancer Hospital; Tianjin Medical University Cancer Institute and Hospital and other collaboratorsRecruitingChemotherapy-induced Thrombocytopenia | HerombopagChina
Clinical Trials on QL0911
-
Qilu Pharmaceutical Co., Ltd.CompletedPrimary Immune ThrombocytopeniaChina
-
Qilu Pharmaceutical Co., Ltd.RecruitingChemotherapy-induced ThrombocytopeniaChina