Quantification of Internal Training Load (QUADRATURE)

December 8, 2023 updated by: Lilian Lacourpaille, Université de Nantes

Quantification of Internal Training Load: Toward the Prediction of the Distribution of Hypertrophy

The aim of this study is to determine whether the distribution of internal load predicts the distribution of muscle hypertrophy among hamstring heads after a 10-week resistance exercise program. The hypothesis is that the distribution of internal muscle load among the hamstring is related to the distribution of muscle hypertrophy.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

It is well accepted that muscle stress (mechanical and/or metabolic) is the major way to induce muscle hypertrophy. While this link between muscle stress and hypertrophy is pivotal is sport training, prevention and rehabilitation, it remains poorly understood. To date, the only indirect evidence of relationship of muscle stress and muscle hypertrophy is the similar patterns (from independent studies) between muscle damage and hypertrophy within quadriceps (i.e., rectus femoris (RF) > vastus (VL) = vastus medialis VM), hamstring, and triceps surae. However, muscle damage is an indirect proof of muscle mechanical stress. With the quantification of internal muscle load, it is interesting to determine whether the muscle that receives the larger stress exhibits the larger hypertrophy.

Study Type

Interventional

Enrollment (Estimated)

36

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • No history of lower limb injury
  • No chronic pathology associated with a long term care

Exclusion Criteria:

  • Individual enrolled in a research study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Nordic
Training regimens composed of nordic exercise
Other: strength training
Strength training, three times a week, during nine weeks.
Experimental: Deadlift
Training regimens composed of deadlift exercise
Other: strength training
Strength training, three times a week, during nine weeks.
No Intervention: Control
Training regimens composed of no exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Muscle volume
Time Frame: 10 weeks
Hypertrophy
10 weeks
Internal training load
Time Frame: 10 weeks
Magnitude and onset/offset of muscle activation
10 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Maximal strength Nordic
Time Frame: 10 weeks
Maximal strength during the Nordic exercise
10 weeks
Maximal strength Deadlift
Time Frame: 10 weeks
Maximal strength during the Deadlift exercise
10 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Université de Nantes

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 29, 2024

Primary Completion (Estimated)

April 2, 2024

Study Completion (Estimated)

May 19, 2024

Study Registration Dates

First Submitted

November 30, 2023

First Submitted That Met QC Criteria

December 8, 2023

First Posted (Estimated)

December 11, 2023

Study Record Updates

Last Update Posted (Estimated)

December 11, 2023

Last Update Submitted That Met QC Criteria

December 8, 2023

Last Verified

December 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • EM_LL_2024

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

Data will be available from a Dryad Digital Repository

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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