- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06181448
Real-World Validation of a Prognostic Prediction Model for Patients With Acute Exacerbations of Chronic Liver Disease
December 13, 2023 updated by: Hai Li, Shanghai Jiao Tong University School of Medicine
Real-World Validation of a Prognostic Prediction Model for Patients With Acute Exacerbations of Chronic Liver Disease: A Multi-Site, Prospective Observational Study
Our study is a multi-site, prospective, observational study including patients with acute exacerbations of CLD.
Approximately 1500 patients from 24 hospitals in diverse regions in China will be enrolled and followed for 3 months.
Data about demographic data, laboratory tests, and clinical manifestations, collected through a mobile application, will inform real-time prognostic scores.
The aim of this study is to validate the model's real-world applicability in non-specialist hospital settings.
Study Overview
Status
Not yet recruiting
Conditions
Detailed Description
The study is a multi-site, prospective, observational study conducted in 24 hospitals representing different regions across China.
The choice of 24 hospitals was based on their representation of diverse geographical regions across China.
These hospitals were selected to ensure a comprehensive validation of the screening model's efficacy in varied healthcare settings.
Data will be collected through a mobile application, providing real-time prognostic scores for patients.
The study is divided into three parts: patient recruitment, in-hospital follow-up, and post-discharge follow-up .
Follow-up will last for 3 months.
Endpoints will be considered for all-cause death, survival and liver transplantation.
The study is planned to enroll 1500 patients from January 2024 to January 2026.
Study Type
Observational
Enrollment (Estimated)
1500
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Hai Li, MD
- Phone Number: +86-13818525494
- Email: haili_17@126.com
Study Locations
-
-
Shanghai
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Shanghai, Shanghai, China, 200120
- Renji Hospital,Shanghai Jiao Tong University School of Medicine
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Contact:
- Hai Li, MD
- Phone Number: 86 13818525494
- Email: haili_17@126.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Probability Sample
Study Population
chronic liver disease patients(with liver dysfunction more than 6 months) with acute liver injury[with ALT>3 ULN),AST>3NL or TB>2 ULN within 1 week before enrollment] or acute decompensation[having ascites, hepatic encephalopathy, bacterial infection ,gastrointestinal bleeding or jaundice(TB > 5ULN)within 1 month before enrollment].
Description
Inclusion Criteria:
- Chronic liver disease with or without cirrhosis, including chronic viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, autoimmune liver disease, metabolic liver disease, chronic drug- induced liver disease and cryptogenic cirrhosis. The duration of underlying non-cirrhotic chronic liver disease should be longer than 6 months.
- Acute exacerbations of chronic liver disease, including acute decompensation (bacterial infection, hepatic encephalopathy, variceal bleeding, ascites and jaundice) in 1 month and liver injury (ALT or AST >3 ULN , or TB>2 ULN) in 1 week.
- Patients are informed of the study purpose and willing to sign the informed consent.
Exclusion Criteria:
- <18 years old or >75 years old
- with malignancy of liver or other organs
- with other serious comorbidities (such as circulatory failure, respiratory failure, chronic kidney disease with end-stage renal failure, stroke within 6 months before admission, severe systemic autoimmune diseases or severe metabolic disease )
- pregnant
- receiving immunosuppressive agents for non-hepatic diseases
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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Hospitalized patients with acute exacerbations of chronic liver disease
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Short-Term Mortality
Time Frame: 3 months
|
All cause mortality within 90 days after admission
|
3 months
|
Short-Term Liver Transplantation Rate
Time Frame: 3 months
|
Liver transplantation rate within 90 days after admission
|
3 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Study Director: Hai Li, MD, Digestive Department of Renji Hospital,Shanghai Jiao Tong University School of Medicine
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
February 1, 2024
Primary Completion (Estimated)
January 31, 2026
Study Completion (Estimated)
January 31, 2026
Study Registration Dates
First Submitted
December 13, 2023
First Submitted That Met QC Criteria
December 13, 2023
First Posted (Actual)
December 26, 2023
Study Record Updates
Last Update Posted (Actual)
December 26, 2023
Last Update Submitted That Met QC Criteria
December 13, 2023
Last Verified
December 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Catchlife-predicting
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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