Post-Resuscitation Pneumothorax - Analysis of Incidence, Risk Factors and Outcome Relevance

December 13, 2023 updated by: Auinger, Daniel MD

Pneumothorax After Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - Analysis of Incidence, Risk Factors and Impact on Outcome

In this retrospective study, the investigators seek to investigate the incidence of pneumothorax following possible risk factors, and elucidate its association with outcomes.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This is a retrospective analysis of routine data, collected by a single Emergency Medical System (EMS). Adult patients (≥18 years) hospitalised after Out-of-Hospital Cardiac Arrest (OHCA) who received chest compressions and underwent chest imaging within 12 hours after hospital admission were included.

Variables and outcomes ascertained are built up of the core elements of the latest version of the Utstein Resuscitation Registry Template for OHCA. This includes sex, age, aetiology of arrest, response times of the first emergency medical service team and emergency physician, witnessed cardiac arrest, bystander CPR/AED, arrest location, first monitored rhythm, defibrillation time, drugs given, reperfusion attempted and target temperature management. Additional variables studied were pre-existing health status represented by the Pre Emergency Status Assessment (PESA), history of lung disease, no-flow-time (time from collapse until initiation of CPR), use of a mechanical chest compression device and prehospital CPR duration.

The primary outcome is incidence of pneumothorax, secondary outcomes are survival to hospital discharge and favourable neurological condition at hospital discharge defined by a cerebral performance category (CPC) of 1 or 2.

Study Type

Observational

Enrollment (Actual)

237

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Austria
    • Styria
      • Graz, Styria, Austria, 8036
        • Medical University of Graz

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Mid-Size European city + surrounding areas

Description

Inclusion Criteria:

  • Hospitalized after out of hospital cardiac arrest
  • Chest compressions received
  • Chest imaging within the first 12 hours of admission

Exclusion Criteria:

  • Traumatic cardiac arrest
  • Chest trauma/surgery/pneumothorax one month prior to cardiac arrest

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
No Pneumothorax
Patients with no pneumothorax reported from the first chest imaging after hospital admission.
Procedure: Cardiopulmonary Resuscitation
Cardiopulmonary Resuscitation (Advanced Life Support) according to current guidelines
Pneumothorax
Patients with a pneumothorax reported from the first chest imaging after hospital admission.
Procedure: Cardiopulmonary Resuscitation
Cardiopulmonary Resuscitation (Advanced Life Support) according to current guidelines

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Presence of pneumothorax
Time Frame: within 12 hours of admission
within 12 hours of admission

Secondary Outcome Measures

Outcome Measure
Time Frame
Survival
Time Frame: to hospital discharge (up to 2 months)
to hospital discharge (up to 2 months)
Cerebral Performance Category
Time Frame: at hospital discharge (up to 2 months)
at hospital discharge (up to 2 months)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Auinger, Daniel MD

Investigators

  • Study Director: Gerhard Prause, Prof., Medical University of Graz

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 2, 2020

Primary Completion (Actual)

October 20, 2022

Study Completion (Actual)

December 31, 2022

Study Registration Dates

First Submitted

December 4, 2023

First Submitted That Met QC Criteria

December 13, 2023

First Posted (Actual)

December 26, 2023

Study Record Updates

Last Update Posted (Actual)

December 26, 2023

Last Update Submitted That Met QC Criteria

December 13, 2023

Last Verified

December 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PostCPRptx

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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