HUTT to Assess Cardiac Autonomic Nervous Function

Composite Autonomic Scoring Scale and HUTT to Assess Cardiac Autonomic Nervous Function: A Preliminary Study

Autonomic nervous system diseases can cause abnormalities in the circulatory system, leading to malignant arrhythmia and sudden cardiac death. Standardized, operable, and simplified diagnostic indicators are urgently needed to evaluate autonomic nervous function, particularly cardiac autonomic nervous function. The investigators use HUTT in order to provide data support for cardiac autonomic nervous system evaluation.

Study Overview

• Status: Recruiting
• Conditions: Autonomic Nervous System Diseases

Detailed Description

In this study, 169 samples with vertical tilt test and 24-h Holter ECG data from February 13, 2023 to October 31, 2023 were selected. The AC, DC, and 24-h HRV were compared with the CASS to identify the indicators with the strongest correlation with the CASS sympathetic and vagus nerve scores. The best index was selected, and the score intervals were delimited. The sensitivity and specificity of the defined vagal and sympathetic intervals were analyzed.

• Study Type: Observational
• Enrollment (Estimated): 1122

Contacts and Locations

• Study Contact: Name: Yan Ding, M.D.; Phone Number: 18633889260; Email: dingding13001300@126.com

Study Locations

• China
  • Hebei
    • Shijiazhuang, Hebei, China, 050000
      • Recruiting
      • The First Hospital of Hebei Medical University
      • Contact: Xuekun Li, Master; Phone Number: 17798061926; Email: xuekunli613@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

A total of 1122 (546 males, 576 females) samples were collected according to the inclusion and exclusion criteria.

Description

Inclusion Criteria:

• Vertical tilt test and 24-hour holter electrocardiogram were performed at the same time

  • Receive treatment in our hospital.

Exclusion Criteria:

• Taking benzodiazepines or hypotensive drugs within 24 hours

  • Combined with mental illness, severe dementia, serious organ disease

    • Severe arrhythmia, deep breathing and poor coordination of Valsaval movements affected the interpretation of results.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To find the indicators which are most correlated to the sympathetic and vagus nerves.	The investigators use HUTT and CASS score to find some indicators which are most correlated to the sympathetic and vagus nerves,so that can give data support to the clinical treatments	February 13, 2023 to December 31, 2025

Collaborators and Investigators

• Sponsor: The First Hospital of Hebei Medical University
• Investigators: Principal Investigator: Yan Ding, M.D., Department of Neurology，Xuanwu Hospital，Capital Medical University，Beijing，China.

Study record dates

Study Major Dates

• Study Start (Actual): January 31, 2024
• Primary Completion (Estimated): December 31, 2025
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: December 27, 2023
• First Submitted That Met QC Criteria: January 24, 2024
• First Posted (Actual): February 1, 2024

Study Record Updates

• Last Update Posted (Actual): September 26, 2024
• Last Update Submitted That Met QC Criteria: September 24, 2024
• Last Verified: September 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Nervous System Diseases; Primary Dysautonomias; Autonomic Nervous System Diseases
• Other Study ID Numbers: 20230213

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No