- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06368271
Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile (Lipidomix)
Acute Effects of Dietary Medium-chain Fatty Acids on Llipid Profile
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days.
On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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-
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Copenhagen, Denmark, 2100
- University of Copenhagen
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Copenhagen, Denmark
- Department of Nutrition, Exercise and Sports
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
healthy males BMI:20-27 recreationally physical active non-smoker no medicine
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Exclusion Criteria:
- high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Intake of fatty acids
,Participants ingest a test drink containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk) within five min.
Blood and oxygen uptake are obtained frequently during the following 4 hours.
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Health beneficial effects of medium-chain fatty acids
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Meal test including medium-chain fatty acids
Time Frame: 0-4 hours
|
In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men.
Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile
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0-4 hours
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Resting metabolic rate
Time Frame: 0-4 hours
|
The secondary outcome of this study is to investigate the effect of an acute intake of MCT or LCT oil (35g of MCT or LCT) on resting metabolic rate in healthy lean men
|
0-4 hours
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Bente Kiens, D.sci, PhD, University of Copenhagen
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- Lipidomix
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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