Factors Affecting Abdominal Compliance During CO2 Insufflation in Laparoscopic Abdominal Surgery

Factors Influencing Abdominal Compliance During CO2 Insufflation in Patients Undergoing Laparoscopic Abdominal Surgery

The authors aimed to evaluate factors influencing abdominal compliance in laparoscopic abdominal surgery.

Study Overview

• Status: Completed
• Conditions: Laparoscopic Surgery
• Intervention / Treatment: Procedure: Laparoscopic surgery

Detailed Description

During laparoscopic surgery, pneumoperitoneum is achieved by insufflating carbon dioxide (CO2) gas into the abdominal cavity to create a safe working space. Pneumoperitoneum-induced elevation in intra-abdominal pressure (IAP) can result in various complications. Abdominal compliance (AC), represents the slope of the P-V curve of the abdominal cavity and is a measure of the ease of abdominal dilatation, is important to balance between surgical safety and complications. The aim of this study was to determine the effect of demographic and anatomic variables on AC.

The study included 90 patients who underwent laparoscopic abdominal surgery. Subcutaneous adipose tissue and abdominal muscle thickness were measured ultrasonographically. Mean AC was calculated during insufflation using the formula (ΔV/ΔP). The relationship between demographic and anatomic variables and AC was investigated

• Study Type: Observational
• Enrollment (Actual): 90

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey
    • Ankara University Medical School Anesthesiology and ICU Department

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

ASA I-III patients aged between 18 and 82 years undergoing elective abdominal surgery with laparoscopic technique.

Description

Inclusion Criteria:

Aged between 18 and 82 years ASA class I-III Elective abdominal surgery with laparoscopic technique

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Exclusion Criteria:

Aged below 18 and above 82 ASA IV-V

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The factors affecting abdominal compliance	Effect of rectus muscle thickness and lateral abdominal muscle group thickness on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The factors affecting abdominal compliance		From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of age on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of gender on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of ASA physical status on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of body mass index on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of previous surgery on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of pregnancy on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery
The factors affecting abdominal compliance	Effect of subcutaneous adipose tissue thickness on abdominal compliance. Abdominal compliance is calculated by dividing intrabdominal volume change to intraabdominal pressure change during abdominal carbondioxide insufflation.	From the beginning of carbondioxide insufflation to the intraabdominal pressure of 15 mmHg during surgery

Collaborators and Investigators

• Sponsor: Ankara University
• Investigators: Study Chair: Menekse Ozcelik, Ankara University; Principal Investigator: Ezgi Yıldırım, Ankara University; Study Chair: Keziban Sanem Çakar Turhan, Ankara University; Principal Investigator: Aysegul Guven, Ankara University; Principal Investigator: Derya Gökmen, Ankara University

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2022
• Primary Completion (Actual): November 30, 2022
• Study Completion (Actual): November 30, 2022

Study Registration Dates

• First Submitted: April 25, 2024
• First Submitted That Met QC Criteria: April 29, 2024
• First Posted (Actual): May 2, 2024

Study Record Updates

• Last Update Posted (Actual): May 2, 2024
• Last Update Submitted That Met QC Criteria: April 29, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: laparoscopic surgery; intraabdominal pressure; abdominal compliance
• Other Study ID Numbers: İ07-432-22

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No