The Impact of Preoperative Suggestion on Dreaming

February 22, 2025 updated by: Cheol Lee,MD,PhD,, Wonkwang University Hospital

The Impact of Preoperative Suggestions on Dreaming With Intravenous Sedation: A Randomized Controlled, Blinded Trial.

Recent studies have shown that positive preoperative suggestions can significantly influence the quality of dreams and reduce the incidence of unpleasant dreams during sedation with agents like ketamine and propofol.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Cheong et al. demonstrated that a simple positive suggestion before ketamine administration could reduce unpleasant dreams, while Kim et al. found that propofol, compared to midazolam, led to more vivid and memorable dreams, along with similar satisfaction levels in patients. This study aims to extend these findings by comparing the effects of propofol and ketamine sedation on dreaming during anesthesia, with a focus on how preoperative suggestions might influence dream content, emotional tone, and patient satisfaction.

Study Type

Interventional

Enrollment (Actual)

250

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Korea, Republic of
    • Please Select
      • Iksan, Please Select, Korea, Republic of, 54538
        • WonwangUH

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Adult patients aged 20-65 years.
  • ASA physical status I-III.
  • Scheduled for elective spinal anesthesia or brachial plexus block.
  • Fluent in Korean.

Exclusion Criteria:

  • Use of any medication, including premedication, within 12 hours before surgery.
  • Cognitive impairments or psychiatric disorders (including a history of unpleasant dreams or nightmares).
  • Current use of sedatives or hypnotics.
  • History of severe or recurrent nightmares.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Single Group Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Control Group with Propofol
Receives standard preoperative instructions and propofol infusion.
Other: Control Group
Receives standard preoperative instructions and propofol or ketamine infusion.
Other Names:
  • Ketamine
  • Propofol
Experimental: Suggestion Group with Propofol
Receives positive preoperative suggestions and propofol infusion.
Other: Suggestion Group
Receives positive preoperative suggestions and propofol or ketamine infusion.
Other Names:
  • Ketamine
  • Propofol
Active Comparator: Control Group with Ketamine
Receives standard preoperative instructions and ketamine infusion.
Other: Control Group
Receives standard preoperative instructions and propofol or ketamine infusion.
Other Names:
  • Ketamine
  • Propofol
Experimental: Suggestion Group with Ketamine
Receives positive preoperative suggestions and ketamine infusion.
Other: Suggestion Group
Receives positive preoperative suggestions and propofol or ketamine infusion.
Other Names:
  • Ketamine
  • Propofol

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Incidence of Dreaming
Time Frame: Dreaming will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU).
The "Dreaming and Cognition Evaluation Questionnaire" will be used.questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance.
Dreaming will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU).
Quality of Dreaming
Time Frame: Dreaming will be assessed immediately in the Post-Anesthesia Care Unit (PACU).
The "Dreaming and Cognition Evaluation Questionnaire" will be used. This questionnaire evaluates the incidence of dreaming, as well as the dream's content, emotional tone (rated on a 1-5 scale from very unpleasant to very pleasant), memorability, visual vividness, intensity, and other qualitative aspects such as sound, movement, and emotional significance.
Dreaming will be assessed immediately in the Post-Anesthesia Care Unit (PACU).

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Satisfaction with Care
Time Frame: Satisfaction will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU)
A 101-point numerical rating scale included in the "Dreaming and Cognition Evaluation Questionnaire" will be used to measure patient satisfaction with the overall care and sedation experience.
Satisfaction will be assessed immediately after full awakeness in the Post-Anesthesia Care Unit (PACU)
Adverse events
Time Frame: Monitoring will be continuous with regular vital signs recorded every 5 minutes during surgery and every 15 minutes in the PACU.
Any complications such as hypotension,or bradycardia, will be recorded systematically.
Monitoring will be continuous with regular vital signs recorded every 5 minutes during surgery and every 15 minutes in the PACU.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Wonkwang University Hospital

Investigators

  • Study Director: Cheol Lee, M.D.,Ph.D, Wonkwang University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 19, 2024

Primary Completion (Actual)

November 25, 2024

Study Completion (Actual)

January 30, 2025

Study Registration Dates

First Submitted

September 22, 2024

First Submitted That Met QC Criteria

September 22, 2024

First Posted (Actual)

September 24, 2024

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

February 22, 2025

Last Verified

February 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Wonkwang UH15

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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