Mechanisms of Fecal Incontinence in Wolfram Syndrome

December 22, 2025 updated by: Christophe Orssaud, Hôpital Necker-Enfants Malades

Physiopathogenic Mechanisms of Fecal Incontinence in Wolfram Syndrome

In order to clarify the mechanism of fecal incontinence in in Wolfram syndrome and to characterize its risk factors, the examiner will reviewed the files of patients followed in a Reference Center for Rare Diseases in Ophthalmology.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
      • Paris, France, 75015
        • HEGP

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

retrospectif cohort of the rare disease center

Description

Inclusion Criteria:

  • Wolfram syndrome

Exclusion Criteria:

  • no information concerning fecal incontinence in data records

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Wolfram syndrome patients with fecal incontience
wolfram syndrome patients without fecal incontinence
Other: Retrospective case-control analysis
retrospective analysis of data
Wolfram syndrome patients without fecal incontience
Other: Retrospective case-control analysis
retrospective analysis of data

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Urinary disorders
Time Frame: The date at the baseline
number of patients with urinary disorder in each group according to the group
The date at the baseline

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
sleep apnea
Time Frame: The date the data will be analyzed at the baseline
number of patients with sleep apnea in each group according to the group
The date the data will be analyzed at the baseline
frequence of swallowing disroder
Time Frame: The data will be analyzed at baseline
number of patients with swallowing disorders in each group according to the group
The data will be analyzed at baseline
frequence of diabetes insipidus
Time Frame: The data will be analyzed at baseline
number of patients with diabetes insipidus in each group according to the group
The data will be analyzed at baseline
mutation type
Time Frame: The data will be analyzed at baseline
report of mutations of WFS1 in each group
The data will be analyzed at baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hôpital Necker-Enfants Malades

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 20, 2025

Primary Completion (Estimated)

January 1, 2026

Study Completion (Estimated)

February 1, 2026

Study Registration Dates

First Submitted

November 15, 2025

First Submitted That Met QC Criteria

December 22, 2025

First Posted (Actual)

December 31, 2025

Study Record Updates

Last Update Posted (Actual)

December 31, 2025

Last Update Submitted That Met QC Criteria

December 22, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • FECINCONTWS1125

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Fecal Incontinence

Clinical Trials on Retrospective case-control analysis

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Malta

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe