- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00070551
GTI-2040 and High-Dose Cytarabine in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia
A Phase I Study of GTI2040 (NSC 722929; IND 67368) in Combination With High-dose Cytarabine in Refractory or Relapsed Acute Myeloid Leukemia (AML)
Studieoversigt
Status
Betingelser
- Tilbagevendende akut myeloid leukæmi hos voksne
- Akut myeloid leukæmi hos voksne med 11q23 (MLL) abnormiteter
- Voksen akut myeloid leukæmi med Inv(16)(p13;q22)
- Voksen akut myeloid leukæmi med t(16;16)(p13;q22)
- Voksen akut myeloid leukæmi med t(8;21)(q22;q22)
- Voksen akut myeloid leukæmi med t(15;17)(q22;q12)
Intervention / Behandling
Detaljeret beskrivelse
PRIMARY OBJECTIVES:
I. Determine the maximum tolerated dose and recommended phase II dose of GTI-2040 and high-dose cytarabine in patients with relapsed or refractory acute myeloid leukemia.
SECONDARY OBJECTIVES:
I. Determine the therapeutic response in patients treated with this regimen. II. Determine the pharmacokinetics of this regimen in these patients.
OUTLINE: This is a dose-escalation study. Patients are stratified according to age (under age 60 vs age 60 and over). Patients are assigned to 1 of 2 strata.
Stratum I (under age 60): Patients receive GTI-2040 IV continuously on days 1-6 and high-dose cytarabine IV over 2 hours twice daily on days 2, 4, and 6.
Stratum II (age 60 and over): Patients receive GTI-2040 IV continuously on days 1-6 and high-dose cytarabine IV over 4 hours once daily on days 2-6.
In both strata, treatment continues in the absence of unacceptable toxicity.
Cohorts of 3-6 patients per stratum receive escalating doses of GTI-2040 and high-dose cytarabine until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity.
PROJECTED ACCRUAL: A total of 6-51patients will be accrued for this study within 2-16 months.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Fase 1
Kontakter og lokationer
Studiesteder
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Ohio
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Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Medical Center
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Histologically confirmed acute myeloid leukemia according to the WHO classification
Relapsed or refractory disease, meeting 1 of the following criteria:
- Unresponsive to initial treatment
- Recurrent disease after treatment with prior conventional or high-dose chemotherapy with or without stem cell support
- CNS involvement allowed provided there are no residual leukemic cells detected in the cerebrospinal fluid after intrathecal or radiation chemotherapy
- Performance status - ECOG 0-2
- At least 4 weeks
- Bilirubin no greater than 2 times upper limit of normal* (ULN) (unless due to Gilbert's syndrome)
- AST and ALT no greater than 3 times ULN*
- Creatinine no greater than 1.5 mg/dL*
- No symptomatic congestive heart failure
- No unstable angina pectoris
- No cardiac arrhythmia
- Resting ejection fraction at least 50%*
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No prior allergy to study medications
- No ongoing or active infection requiring IV antibiotics
- No other concurrent uncontrolled illness
- No serious medical or psychiatric illness that would preclude giving informed consent
- More than 4 weeks since prior chemotherapy (except hydroxyurea) (6 weeks for nitrosoureas or mitomycin)
- No other concurrent chemotherapy
- No concurrent hormonal therapy except steroids for adrenal failure and hormones for non-disease-related conditions (e.g., insulin for diabetes)
- More than 4 weeks since prior radiotherapy
- No concurrent palliative radiotherapy
- Prior therapy with antisense oligonucleotides allowed provided no toxic effects were experienced that were directly attributable to the antisense agents
- No other concurrent investigational agents
- No other concurrent anticancer therapy
No concurrent chronic systemic anticoagulant therapy for medical conditions (e.g., prior deep vein thrombosis or atrial fibrillation)
- Concurrent heparin to maintain central line patency (i.e., catheter flush) is allowed
- No concurrent combination antiretroviral therapy for HIV-positive patients
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Ikke-randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Stratum I (GTI-2040, cytarabine)
Patients receive GTI-2040 IV continuously on days 1-6 and high-dose cytarabine IV over 2 hours twice daily on days 2, 4, and 6.
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Givet IV
Andre navne:
Valgfri korrelative undersøgelser
Valgfri korrelative undersøgelser
Andre navne:
Givet IV
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Eksperimentel: Stratum II (GTI-2040, cytarabine)
Patients receive GTI-2040 IV continuously on days 1-6 and high-dose cytarabine IV over 4 hours once daily on days 2-6.
In both strata, treatment continues in the absence of unacceptable toxicity.
|
Givet IV
Andre navne:
Valgfri korrelative undersøgelser
Valgfri korrelative undersøgelser
Andre navne:
Givet IV
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Maximum-tolerated dose (MTD) as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0
Tidsramme: Up to day 42
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Up to day 42
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Therapeutic response
Tidsramme: Up to 6 years
|
Standard paired statistical tests, parametric and nonparametric, will be used to baseline with treatment values.
With data collected serially over time, repeated measures analysis of variance will be used to analyze data.
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Up to 6 years
|
Change in R2 expression in circulating and marrow leukemia cells
Tidsramme: From baseline to up to 6 years
|
Standard paired statistical tests, parametric and nonparametric, will be used to baseline with treatment values.
With data collected serially over time, repeated measures analysis of variance will be used to analyze data.
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From baseline to up to 6 years
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Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Ledende efterforsker: Guido Marcucci, Ohio State University
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neoplasmer efter histologisk type
- Neoplasmer
- Leukæmi
- Leukæmi, myeloid
- Leukæmi, Myeloid, Akut
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Anti-infektionsmidler
- Antivirale midler
- Antimetabolitter, Antineoplastisk
- Antimetabolitter
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Cytarabin
Andre undersøgelses-id-numre
- NCI-2012-01443
- U01CA076576 (U.S. NIH-bevilling/kontrakt)
- 0304
- CDR0000334898
- OSU-20030030
- NCI-6108
- OSU-0304
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