- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00538161
Effect of Low Tidal Volume Ventilation in Improving Oxygenation and Thus Reducing Acute Lung Injury in the Cardiac Surgical Patient
15. marts 2017 opdateret af: Sugantha Sundar, Beth Israel Deaconess Medical Center
We propose that as low tidal volume ventilation has proven to be beneficial in patients with established ARDS it may have a role in preventing the onset of acute lung injury in the cardiac surgical population.
Institution of low tidal volume ventilation in the operating room may reduce the release of the cytokines and interleukins that have been known to contribute to the development of acute lung injury.
In this study, we propose that the institution of low tidal volume ventilation in the operating room will reduce the incidence of acute lung injury.
Measurement of PaO2 to FiO2 ratio twenty four and forty eight hours post operatively will help determine if there is a difference in oxygenation between the two groups.
Chest X-ray findings, time to extubation and length of ICU stay will also determine if there is a role for low tidal volume ventilation in the operating room.
We will also attempt to establish a causative mechanism by measuring plasma levels of cytokines known to be associated with the development of ARDS.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Methods- A single center randomized controlled trial was undertaken in 149 patients comparing ventilation with 6 ml/kg TV to ventilation with 10 ml/kg TV in patients undergoing elective cardiac surgery.
Study ventilator settings were applied immediately after induction of anesthesia and continued throughout surgery and the subsequent Intensive Care Unit stay.
The primary endpoint of the study was time to extubation.
Secondary endpoints included the proportion of patients extubated at 6 hours, indices of lung mechanics and gas exchange as well as patient clinical outcomes.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
150
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
-
-
Massachusetts
-
Boston, Massachusetts, Forenede Stater, 02215
- Beth Israel Deaconess Medical Center
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Patients coming in for cardiac surgical procedures will be recruited into the study.
- Both men and women will be recruited into the study.
- All patients over the age of 18 will be recruited into the study.
- Discussion between the surgeon and the primary investigator will happen prior to approaching the patient to obtain informed consent.
Exclusion Criteria:
- Patients with preexisting respiratory failure and active infection will be excluded from the study.
- Patients undergoing one lung ventilation during surgery will be excluded from the study.
- Patients undergoing emergency cardiac surgery will be excluded from the study.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Low tidal volume arm
|
|
Aktiv komparator: Conventional tidal volume arm
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Time to extubation
Tidsramme: the time patient was extubated in the ICU
|
the time patient was extubated in the ICU
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
---|---|
Oxygenation at 4 hours, 8 hours, 12 hours and 24 hours post surgery.
Tidsramme: measurement of blood gas at 4, 8 , 12 and 24 hours post surgery
|
measurement of blood gas at 4, 8 , 12 and 24 hours post surgery
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Efterforskere
- Studieleder: Daniel Talmor, MD, Beth Israel Deaconess Medical Center
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. oktober 2007
Primær færdiggørelse (Faktiske)
1. oktober 2009
Studieafslutning (Faktiske)
1. januar 2011
Datoer for studieregistrering
Først indsendt
30. september 2007
Først indsendt, der opfyldte QC-kriterier
1. oktober 2007
Først opslået (Skøn)
2. oktober 2007
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
17. marts 2017
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
15. marts 2017
Sidst verificeret
1. marts 2017
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
- hjertekirurgi
- Akut lungeskade
- The incidence of ARDS after elective cardiac surgery is 1-3%
- The impairment of lung function and oxygenation may occur in 20-80% of patients undergoing surgery.
- The purpose of this study is to assess the efficacy of low tidal volume ventilation.
- Reducing interleukin and cytokine production may prevent or reduce the incidence of acute lung injury.
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2007P000113
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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