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A Post Marketing Evaluation of the Effectiveness of FluMist Risk Minimization Plan in Children

21. juli 2014 opdateret af: MedImmune LLC

A Post Marketing Evaluation of the Effectiveness of the Risk Minimization Plan For Use of FluMist Among Children Less Than 5 Years of Age

This is a retrospective cohort study of children included in a large medical insurance claims database.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

  • To evaluate the rate of FluMist administration compared to other influenza vaccine use in the following pediatric populations:

    • Children younger than 24 months of age
    • Children 24-59 months of age with a claim associated with a diagnosis of asthma
    • Children 24-59 months of age without a claim associated with a diagnosis of asthma, but with dispensed medication for wheezing
    • Children 24-59 months of age with immunosuppression
  • To describe, in children in the above populations who receive FluMist, the type and number of Emergency Room visits or hospitalizations associated with an insurance claim within 42 days of receiving FluMist
  • To explore the rationale for FluMist immunization of pediatric populations that are excluded from recommended usage by characterizing the use in these populations

Undersøgelsestype

Observationel

Tilmelding (Faktiske)

321697

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • North Carolina
      • Research Triangle, North Carolina, Forenede Stater
        • Research Site

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

Children < 60 months of age.

Beskrivelse

  • Children less than 24 months of age during August through January/February.

  • Children <24 to 59 months of age during August through January/February, with:

    • two outpatient claims for asthma, or
    • one inpatient/emergency room claim for asthma, or
    • one outpatient claim for asthma and at least one SABA prescription during a defined 12-month period.
  • Children <24 to 59 months of age during August through January/February, without any claims associated with a diagnosis of asthma, but with at least one dispensing for SABA, as indicated by pharmacy claims during a defined 12-month period.
  • Children 24 to 59 months of age during August to January/February with evidence of immunosuppression prior to the date of influenza vaccination based on available medical and pharmacy claims.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Observationsmodeller: Kohorte
  • Tidsperspektiver: Tilbagevirkende kraft

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
1
Children less than 24 months of age
Medicin: No Intervention
There were no interventions. No subjects were enrolled in this retrospective database study.
2
Children 24 to 59 months of age with a claim associated with a diagnosis of asthma
Medicin: No Intervention
There were no interventions. No subjects were enrolled in this retrospective database study.
3
Children 24 to 59 months of age without a claim associated with a diagnosis of asthma, but with dispensed medication for wheezing
Medicin: No Intervention
There were no interventions. No subjects were enrolled in this retrospective database study.
4
Children 24-59 months of age with immunosuppression
Medicin: No Intervention
There were no interventions. No subjects were enrolled in this retrospective database study.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
FluMist Use in Participants up to 59 Months of Age
Tidsramme: 2009-2010
Among participants up to 59 months of age who received any flu vaccine, number who received FluMist
2009-2010
Vaccinating Physician Specialty: Pediatrician or Pediatric Specialist
Tidsramme: 2009-2010
Specialty of vaccinating physician who provided FluMist.
2009-2010
Vaccinating Physician Specialty: General/Family Practitioner
Tidsramme: 2009-2010
Specialty of vaccinating physician who provided FluMist
2009-2010
Vaccinating Physician Specialty: Other
Tidsramme: 2009-2010
Specialty of vaccinating physician who provided FluMist
2009-2010
Vaccinating Physician Specialty: Unknown
Tidsramme: 2009-2010
Specialty of vaccinating physician who provided FluMist
2009-2010
Geographic Region: Northeastern
Tidsramme: 2009-2010
Geographic region of parents' residence among participants receiving FluMist
2009-2010
Geographic Region: North Central
Tidsramme: 2009-2010
Geographic region of parents' residence among participants receiving FluMist
2009-2010
Geographic Region: Southern
Tidsramme: 2009-2010
Geographic region of parents' residence among participants receiving FluMist
2009-2010
Geographic Region: Western
Tidsramme: 2009-2010
Geographic region of parents' residence among participants receiving FluMist
2009-2010
Number of Outpatient Visits: 0
Tidsramme: 2009-2010
Among participants vaccinated with FluMist, the number who had 0 outpatient visits in the 3 months prior to vaccination
2009-2010
Number of Outpatient Visits: 1
Tidsramme: 2009-2010
Among participants vaccinated with FluMist, the number who had 1 outpatient visit in the 3 months prior to vaccination
2009-2010
Number of Outpatient Visits: 2 or More
Tidsramme: 2009-2010
Among participants vaccinated with FluMist, the number who had 2 or more outpatient visits in the 3 months prior to vaccination
2009-2010
Number of Days With a Respiratory Claim in 28 Days Prior to Vaccination: 0
Tidsramme: 2009-2010
Among participants vaccinated with FluMist, the number of days with a respiratory claim (asthma, acute respiratory distress, bronchospasm, influenza, respiratory syncytial virus, bronchiolitis, bronchitis, pneumonia, croup, sinusitis, adenovirus infection, coxsackie virus infection, rhinovirus infection, nasopharyngitis, laryngitis and tracheitis, upper respiratory infection, cough) in the 28 days prior to vaccination.
2009-2010
Number of Days With a Respiratory Claim in 28 Days Prior to Vaccination: 1
Tidsramme: 2009-2010
Among participants vaccinated with FluMist, the number of days with a respiratory claim (asthma, acute respiratory distress, bronchospasm, influenza, respiratory syncytial virus, bronchiolitis, bronchitis, pneumonia, croup, sinusitis, adenovirus infection, coxsackie virus infection, rhinovirus infection, nasopharyngitis, laryngitis and tracheitis, upper respiratory infection, cough) in the 28 days prior to vaccination.
2009-2010
Number of Days With a Respiratory Claim in 28 Days Prior to Vaccination: 2 or More
Tidsramme: 2009-2010
Among participants vaccinated with FluMist, the number of days with a respiratory claim (asthma, acute respiratory distress, bronchospasm, influenza, respiratory syncytial virus, bronchiolitis, bronchitis, pneumonia, croup, sinusitis, adenovirus infection, coxsackie virus infection, rhinovirus infection, nasopharyngitis, laryngitis and tracheitis, upper respiratory infection, cough) in the 28 days prior to vaccination.
2009-2010

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

MedImmune LLC

Samarbejdspartnere

RTI International

Efterforskere

  • Studieleder: Chris Ambrose, M.D., MedImmune LLC

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. oktober 2007

Primær færdiggørelse (Faktiske)

1. marts 2010

Studieafslutning (Faktiske)

1. marts 2010

Datoer for studieregistrering

Først indsendt

20. februar 2008

Først indsendt, der opfyldte QC-kriterier

20. februar 2008

Først opslået (Skøn)

29. februar 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

12. august 2014

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

21. juli 2014

Sidst verificeret

1. juli 2014

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • MI-MA175

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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Sponsorer og samarbejdspartnere

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Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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