- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01133964
Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure (MAES)
Studieoversigt
Detaljeret beskrivelse
Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety.
Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently.
The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation.
The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
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Copenhagen, Danmark, 1958
- Department og Human Nutrition, Life, University of Copenhagen
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- healthy males
- body mass index (BMI) 25-30 kg/m2
- 18-50 years
- weight stable
Exclusion Criteria:
- smoker
- regular use of medicine
- elitist athletes
- participation in other intervention studies
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Forebyggelse
- Tildeling: Randomiseret
- Interventionel model: Crossover opgave
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: milk
skim milk
|
Protein drinks with 3.5% protein.
The protein source will be whey, casein or whey and casein (20:80; normal content in the milk).
In the arm with water no protein will be added.
|
Eksperimentel: casein drink
|
Protein drinks with 3.5% protein.
The protein source will be whey, casein or whey and casein (20:80; normal content in the milk).
In the arm with water no protein will be added.
|
Eksperimentel: whey drink
|
Protein drinks with 3.5% protein.
The protein source will be whey, casein or whey and casein (20:80; normal content in the milk).
In the arm with water no protein will be added.
|
Sham-komparator: water
|
Protein drinks with 3.5% protein.
The protein source will be whey, casein or whey and casein (20:80; normal content in the milk).
In the arm with water no protein will be added.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Subjective appetite sensation
Tidsramme: 5 hours
|
5 hours
|
Energy expenditure
Tidsramme: 5 hours
|
5 hours
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Substrate oxidation
Tidsramme: 5 hours
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5 hours
|
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Arne Astrup, Dr., Department of Human Nutrition, Life, University of Copenhagen
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Andre undersøgelses-id-numre
- B256
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Kliniske forsøg med dairy proteins
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Athena Institute, NetherlandsYakult Europe BVUkendtForstoppelse | Diarré
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Anglia Ruskin UniversityDanone Nutricia ResearchRekrutteringGastrointestinal dysfunktion | AminosyreændringDet Forenede Kongerige
-
USDA Grand Forks Human Nutrition Research CenterAktiv, ikke rekrutterendeFedmeForenede Stater
-
University of AarhusArla Foods; Mejeribrugets ForskningsFond; Innovation foundationAfsluttetProteinmetabolismeDanmark
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USDA Grand Forks Human Nutrition Research CenterNorth Dakota Beef CommissionAfsluttet
-
Arne AstrupAfsluttetUndersøgelsesfokus: AppetitDanmark
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Pennington Biomedical Research CenterAfsluttet
-
University of KielAfsluttet
-
University of UtahAfsluttet