New Genes in the Carcinogenesis of Colorectal Cancer
Investigating the Role of SPG20,STK31 Genes in the Carcinogenesis of Colorectal Cancer
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
colo rectal cancer represents a global and local problem, as it is one of the commonest types of cancer all over the world. Globally, Colo rectal cancer in women (9.2% of diagnoses) it is the second most common cause of cancer . it is the third most common in men (10.0%). After lung, stomach, and liver cancer it is the fourth most common cause of cancer death.
Cancer is a multistep procedure resulting from an ongoing accretion of genetic and epigenetic fluctuations to the genome.
Spartin is a protein that in humans is encoded by the SPG20 gene. This protein may be involved in endosomal trafficking, microtubule dynamics, or both functions. Aberrant promoter methylation of genes is a common epigenetic alteration in colo rectal cancer .
This has stimulated the prospect to implement a dependable, reasonable and simple approach for Colo rectal detection . The SPG20 gene is situated in chromosome band 13q13.3; the SPG20 gene converts the spartin protein, which is a multi functional protein that has formerly been recognized to be complicated in intra cellular epidermal growth factor receptor trading , The serine-threonine kinase 31 (STK31) gene was initially identified through cDNA subtraction as a testis-specific protein kinase gene expressed in mouse spermatogonia . Recently, STK31 has been described as a novel cancer testis (CT) antigen, highly expressed in Gastrointestinal cancer cells (colo rectal, gastric and esophageal cancer), while restricted to testis and fetal brain in normal tissues .
It was found that SPG20 is mutated in Troy er syndrome, an hereditary spastic paraplegia
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- age between 35-65
- patient with colorectal cancer (at any stage)
- both sex included
Exclusion Criteria:
- pediatric patients
- patient with insufficient data
- cardiac patient
- pregnant women
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: Case-Control
- Tidsperspektiver: Fremadrettet
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
patient with cancer
blood sample will be collected from patient before and after treatment (surgery or chemotherapy)
|
Total genomic DNA will be extracted DNA extraction kit using a QIAamp DNA Blood Mini kit .Genetic analysis of both SPG20 &STK31 by RTPCR.
|
|
healthy people
blood sample will be collected for comparison
|
Total genomic DNA will be extracted DNA extraction kit using a QIAamp DNA Blood Mini kit .Genetic analysis of both SPG20 &STK31 by RTPCR.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
detection of SPG20&STK31 genes
Tidsramme: 5 months
|
detection of SPG20&STK31 genes and prediction future treatment for colo-rectal cancer
|
5 months
|
Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart (Forventet)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- CRC (NINDS)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
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Kliniske forsøg med Colo-rektal cancer
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Chinese PLA General HospitalIkke rekrutterer endnu
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Gruppo Oncologico Italiano di Ricerca ClinicaGlaxoSmithKlineIkke rekrutterer endnu
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National Cancer Institute, NaplesRekrutteringLocally Advanced Rectal Cancer (LARC)Italien
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Cai ZerongAfsluttet
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East Kent Hospitals University NHS Foundation TrustAfsluttetColo-rektal kirurgiDet Forenede Kongerige
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Chinese University of Hong KongUkendt
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National Taiwan University HospitalIkke rekrutterer endnuKoloskopi | Colo-rektale polypper
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Istituto Scientifico Romagnolo per lo Studio e...Istituto Oncologico Romagnolo (IOR)RekrutteringColo-rektal cancerItalien
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University of Roma La SapienzaAfsluttetColo-rektal anastomose dehiscens
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Universitätsmedizin MannheimAfsluttetColo-kolon anastomose | Ileo-koloniske AnastomoserTyskland
Kliniske forsøg med blood sample
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Hillel Yaffe Medical CenterUkendt
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University of Colorado, DenverAktiv, ikke rekrutterendeEnkelt-ventrikel | Abnormitet i pulmonal vaskulær modstand | Metabolomics | Superior Cavo-pulmonal anastomose | EndotelinForenede Stater
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Sun Yat-sen UniversityRekruttering
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ExThera Medical Europe BVExThera Medical Corporation; Vivantes Clinic NeuköllnRekrutteringBlodbaneinfektionFrankrig, Tyskland, Holland, Østrig, Belgien, Italien, Polen, Spanien, Det Forenede Kongerige
-
Ascensia Diabetes CareAfsluttet
-
Ascensia Diabetes CareAfsluttetDiabetesForenede Stater
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Stanford UniversityRekrutteringKarsygdomme | Slag | Forhøjet blodtryk | TIAForenede Stater
-
Ascensia Diabetes CareAfsluttetDiabetesForenede Stater
-
Sohag UniversityIkke rekrutterer endnuPrædiabetisk tilstand | Prædiabetisk tilstand (IGT)Egypten
-
University of British ColumbiaIkke rekrutterer endnuForhøjet blodtryk