- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT03349879
Familial Clustering of Vitamin D Deficiency Via Shared Environment: The Korean National Health And Nutrition Examination Survey 2008-2012
21. november 2017 opdateret af: Yonsei University
Vitamin D deficiency is a modifiable risk factor for poor bone health.
Familial correlation of serum 25-hydroxyvitamin D concentration (25(OH)D) was reported in twin- or family-based studies, mostly from Caucasian parent-offspring pairs.
However, data on the familial association of 25(OH)D in extended family structure and the relative contribution of genetic and shared environmental factors on serum 25(OH)D level are limited in Asian populations.
In this study, the investigators aimed to assess the relative contribution of additive genetic and environmental components on serum 25(OH)D level by variance components method in a nationwide family-based cohort.
Further, the investigators will evaluate the association of vitamin D status of index individual with prevalent vitamin D deficiency of each family member including spouse, offspring, sibling, and grand-offspring.
Additive influences of paternal and maternal vitamin D status on offspring will be also investigated.
Studieoversigt
Status
Afsluttet
Betingelser
Detaljeret beskrivelse
From the Korean National Health and Nutritional Examination Survey (KNHANES) conducted between 2008 and 2012, familial correlations for 25(OH)D will be estimated in different types of family relation pairs in 28551 subjects from 10882 families.
The relative contribution of additive genetic and shared or individual environmental factors for variance of 25(OH)D level will be calculated using variance component method.
Interactions between paternal and maternal vitamin D status for 25(OH)D level of offspring will be evaluated.
Undersøgelsestype
Observationel
Tilmelding (Faktiske)
28551
Kontakter og lokationer
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Studiesteder
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Seoul, Korea, Republikken, 03722
- Division of Endocrinology, Department of internal Medicine, Yonsei University College of Medicine, Severance Hospital
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
10 år til 95 år (Barn, Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Prøveudtagningsmetode
Sandsynlighedsprøve
Studiebefolkning
This study was based on data from the Korean National Health and Nutrition Examination Survey (KNHANES) (IV-2, 3 and V), conducted from 2008 to 2012.
The KNHANES is a nationwide cross-sectional survey performed by the Division of Chronic Disease Surveillance, Korea Centers for Disease Control and Prevention (CDC), which assessed the health, nutritional status, and socioeconomic status of the non-institutionalized civilian population of South Korea.
Subjects were selected using a stratified multistage clustered probability sampling design.
Families, including at least two family members with serum 25(OH)D measurements and whose family relationships could be accurately identified were selected for the study.
After the selection process, a total of 28,551 subjects from 10,882 families were included in our study.
Beskrivelse
Inclusion Criteria:
- KNHANES(Korean National Health and Nutrition Examination Survey) 2008-2012 participants
Exclusion Criteria:
- missing value on 25-hydroxyvitamin D levels
- data on another household member was unavailable
- the precise family relationship between the subjects was unclear
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: Familiebaseret
- Tidsperspektiver: Tilbagevirkende kraft
Kohorter og interventioner
Gruppe / kohorte |
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Vitamin D deficiency
serum 25(OH)D < 30 nmol/L
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Vitamin D insufficiency
serum 25(OH)D between 30 and 49 nmol/L
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Vitamin D sufficiency
serum 25(OH)D ≥ 50 nmol/L
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Vitamin D deficiency
Tidsramme: 1 minute after the survey (cross-sectional analysis)
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Vitamin D deficiency (serum 25(OH)D < 30 nmol/L)
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1 minute after the survey (cross-sectional analysis)
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
1. januar 2008
Primær færdiggørelse (Faktiske)
31. december 2012
Studieafslutning (Faktiske)
31. december 2012
Datoer for studieregistrering
Først indsendt
16. november 2017
Først indsendt, der opfyldte QC-kriterier
19. november 2017
Først opslået (Faktiske)
22. november 2017
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
24. november 2017
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
21. november 2017
Sidst verificeret
1. november 2017
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2012-01EXP-01-2C
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