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rTMS for the Prevention Treatment of CM: a Single Arm Study

22. juni 2018 opdateret af: Peking Union Medical College Hospital

Repetitive Transcranial Magnetic Stimulation for the Prevention Treatment of Chronic Migraine: a Single Arm Study

We design this pilot, single arm study to explore the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for the treatment of chronic migraine. The hypothetical control group is pooled sham group in latest meta-analysis. We expect a significant improvement of the outcome measures during and after the treatment as compared to the hypothetical control group.

Studieoversigt

Status

Ukendt

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

After a 28-day prospective baseline period using a headache diary to record headache symptoms and any abortive medications used, subjects who meet diagnostic criteria for chronic migraine and don't meet the exclusion criteria will receive rTMS for 4 weeks. The outcome measure will be evaluated at 4 weeks. During the whole trial period, any adverse events are requested to be recorded in the headache diary for analyses. The primary outcome is 50% reduction in the number of days with headache. 50% reduction as assessed by migraine days, moderate/severe headache days, the mean VRS, and conversion to episodic migraine, SGIC, the change from baseline HALT-28, HIT-6, and MSQ v2.1, are used as secondary outcome measures for exploring other benefits associated with treatment.

Undersøgelsestype

Interventionel

Tilmelding (Forventet)

15

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 65 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Subjects meeting the diagnostic criteria for chronic migraine according to the International Classification of Headache Disorders, 3rd edition.
  • The duration of chronic migraine ≥ 6 months.
  • age range of 18 - 65 years old

Exclusion Criteria:

  • Secondary headaches except MOH
  • any change of the prophylaxis or the analgesic drug strategy during the baseline and follow-up period
  • structural brain lesions
  • seizures
  • severe systemic disease
  • TMS contraindications (such as metal implants)
  • psychosis
  • severe depression or anxiety
  • drug or alcohol dependence
  • pregnancy
  • participating in other experiments at the same time

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: N/A
  • Interventionel model: Enkelt gruppeopgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: rTMS group
Enhed: rTMS
The subjects will receive 20 trains of 100 stimuli each delivered at 10 Hz and 80% of MT over the left MC (M1), 3 days a week, for 4 weeks.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
50% reduction in the Number of Days with Headache
Tidsramme: at 4 weeks
A Headache day is defined as a day with a headache that lasts at least 4 hours.
at 4 weeks

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
50% reduction in the Number of Migraine Days
Tidsramme: at 4 weeks
A migraine day is defined as a day with a headache that lasts at least 4 hours; meets ICHD-III criteria C and D for migraine without aura (1.1), B and C for migraine with aura (1.2), or ICHD-III criteria for probable migraine (1.6); or a day with a headache that is successfully treated with a triptan, ergotamine, or other migraine-specific acute medication.
at 4 weeks
50% reduction in the Number of Moderate/Severe Headache Days
Tidsramme: at 4 weeks
A moderate/severe headache day is defined as a day with moderate or severe pain that lasts at least 4 hours or a day with a headache that is successfully treated by an acute headache medication.
at 4 weeks
Conversion to episodic migraine
Tidsramme: at 4 weeks
Defined as the proportion of subjects with fewer than 14 migraine or headache days per 4 weeks.
at 4 weeks
The Subject's Global Impression of Change (SGIC)
Tidsramme: at 4 weeks
Global impression of change was scored using a 7-point scale for each instrument, ranging from 1 (very much improved) to 7 (very much worse), with a 4-week recall period. We'll estimate the proportion of patients who reported any improved (very much improved, much improved, minimally improved).
at 4 weeks
Change from Baseline HALT-28 (Headache-Attributed Lost Time - 28 days)
Tidsramme: at baseline and 4 weeks
HALT-30 is closely based on the first five questions of MIDAS, developed by RB Lipton and WF Stewart. We modify the time interval to capture migraine-related disability with a 4-week recall period.
at baseline and 4 weeks
Change from Baseline HIT-6 (Headache Impact Test-6)
Tidsramme: at baseline and 4 weeks
HIT-6 is for capturing migraine-related disability with a 4-week recall period.
at baseline and 4 weeks
Change from Baseline MSQ v2.1 (the Migraine-Specific Quality of Life questionnaire v2.1)
Tidsramme: at baseline and 4 weeks
To evaluate the change in quality of life related to chronic migraine with a 4-week recall period.
at baseline and 4 weeks
50% reduction as assessed by the mean VRS
Tidsramme: at 4 weeks
Subjects will be instructed to record the pain intensity of each day using 11-point Visual Rating Scale (VRS). The mean VRS is defined as the mean of the maximum VRS of each day with a 4-week period.
at 4 weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Peking Union Medical College Hospital

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Forventet)

30. juni 2018

Primær færdiggørelse (Forventet)

31. december 2021

Studieafslutning (Forventet)

30. juni 2022

Datoer for studieregistrering

Først indsendt

4. juni 2018

Først indsendt, der opfyldte QC-kriterier

22. juni 2018

Først opslået (Faktiske)

26. juni 2018

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

26. juni 2018

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

22. juni 2018

Sidst verificeret

1. juni 2018

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • rTMSCM-PUMCH

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

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