Ten Fraction Adjuvant Hypofractionated Radiotherapy in Node Positive Breast Cancer (HIPOMAMMLINF)

Inclusion Criteria:

• Patients affected by invasive breast cancer who underwent conservative breast surgery or mastectomy and axillary dissection, followed by post operative radiotherapy at the level of the breast/chest wall, and of the supraclavicular, third axillary level +/- internal mammary chain nodes.
• pT1-3 disease pN1-2, cT1-3 disease if neoadjuvant chemotherapy , cN + cytologically and/or histologically assessed;
• ECOG Performance status ≤2;
• histologically negative surgical margins
• no distant metastases
• no prior chest radiotherapy
• life expectancy ≥ 5 years
• no prior cancer

Exclusion Criteria:

• Non-epithelial breast cancer (sarcoma, lymphoma etc.)
• Metastases at the level of the internal chain mammary and / or supra-clavicular lymph nodes histologically assessed
• pT4 neoplasms or inflammatory breast carcinoma
• Distant metastasis
• Concomitant chemotherapy
• history of prior controlateral breast tumor