Denne side blev automatisk oversat, og nøjagtigheden af oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal Intubation

18. maj 2026 opdateret af: Yanhua Guo, Fujian Provincial Hospital

Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal Intubation: Prospective Randomized Double-blind Study

This randomized, double-blind, controlled clinical study will evaluate the effects of different dose combinations of intravenous metoprolol and sufentanil on cardiovascular responses during oral endotracheal intubation under general anesthesia.

Endotracheal intubation may cause transient increases in heart rate and blood pressure due to sympathetic stimulation. This study aims to determine whether metoprolol, in combination with different doses of sufentanil, can improve hemodynamic stability during and after intubation.

A total of 900 adult patients aged 18 to 65 years with American Society of Anesthesiologists physical status I or II who are scheduled for elective non-cardiac surgery under general anesthesia with endotracheal intubation will be enrolled. Participants will be randomly assigned to one of 30 groups according to the combination of metoprolol dose and sufentanil dose. Metoprolol doses include 0, 0.1, 0.2, 0.3, 0.4, and 0.5 mg/kg, and sufentanil doses include 0.1, 0.2, 0.3, 0.4, and 0.5 mcg/kg.

All participants will receive standardized anesthetic induction and maintenance. Hemodynamic changes will be observed for 10 minutes after intubation. The main outcome is the success rate of hemodynamic stability within 0 to 10 minutes after intubation. Secondary outcomes include the incidence of hypotension, hypertension, bradycardia, and tachycardia.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

General Anesthesia; Tracheal Intubation

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

900

Fase

Fase 4

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Navn: Yanhua Guo
Telefonnummer: +86-18050333902
E-mail: guoyanhua19@126.com

Studiesteder

Kina
- Fujian
  - Fuzhou, Fujian, Kina, 350000
    - Fujian Provincial Hospital
    - Kontakt:
      
      Yanhua Guo
      
      Telefonnummer: +86-18050333902
      
      E-mail: guoyanhua19@126.com

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

Voksen
Ældre voksen

Tager imod sunde frivillige

Ingen

Beskrivelse

Inclusion Criteria:

Age 18 to 65 years.
American Society of Anesthesiologists physical status I or II.
Scheduled for elective non-cardiac surgery.
Planned general anaesthesia with endotracheal intubation.

Exclusion Criteria:

Cardiovascular or respiratory diseases, such as uncontrolled hypertension or bronchial asthma.
Current use of β-blockers.
History of chronic drug use or alcohol abuse.
Hepatic or renal impairment.
Known allergy to any study drug.
Anticipated difficult airway.
Any other condition that may affect the conduct of the study.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Forebyggelse
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Tredobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Aktiv komparator: Metoprolol 0 mg/kg + Sufentanil 0.1 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Normal Saline (0.9% NaCl) Normal saline (0.9% NaCl) will be administered intravenously before anesthetic induction as placebo in a volume matched to the metoprolol intervention. The study drug will be delivered through a dedicated intravenous catheter, and participants assigned to the placebo arm will receive a volume corresponding to the randomized dosing schedule used in the metoprolol groups.
Aktiv komparator: Metoprolol 0 mg/kg + Sufentanil 0.2 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Normal Saline (0.9% NaCl) Normal saline (0.9% NaCl) will be administered intravenously before anesthetic induction as placebo in a volume matched to the metoprolol intervention. The study drug will be delivered through a dedicated intravenous catheter, and participants assigned to the placebo arm will receive a volume corresponding to the randomized dosing schedule used in the metoprolol groups.
Aktiv komparator: Metoprolol 0 mg/kg + Sufentanil 0.3 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Normal Saline (0.9% NaCl) Normal saline (0.9% NaCl) will be administered intravenously before anesthetic induction as placebo in a volume matched to the metoprolol intervention. The study drug will be delivered through a dedicated intravenous catheter, and participants assigned to the placebo arm will receive a volume corresponding to the randomized dosing schedule used in the metoprolol groups.
Aktiv komparator: Metoprolol 0 mg/kg + Sufentanil 0.4 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Normal Saline (0.9% NaCl) Normal saline (0.9% NaCl) will be administered intravenously before anesthetic induction as placebo in a volume matched to the metoprolol intervention. The study drug will be delivered through a dedicated intravenous catheter, and participants assigned to the placebo arm will receive a volume corresponding to the randomized dosing schedule used in the metoprolol groups.
Aktiv komparator: Metoprolol 0 mg/kg + Sufentanil 0.5 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Normal Saline (0.9% NaCl) Normal saline (0.9% NaCl) will be administered intravenously before anesthetic induction as placebo in a volume matched to the metoprolol intervention. The study drug will be delivered through a dedicated intravenous catheter, and participants assigned to the placebo arm will receive a volume corresponding to the randomized dosing schedule used in the metoprolol groups.
Eksperimentel: Metoprolol 0.1 mg/kg + Sufentanil 0.1 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.1 mg/kg + Sufentanil 0.2 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.1 mg/kg + Sufentanil 0.3 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.1 mg/kg + Sufentanil 0.4 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.1 mg/kg + Sufentanil 0.5 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.2 mg/kg + Sufentanil 0.1 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.2 mg/kg + Sufentanil 0.2 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.2 mg/kg + Sufentanil 0.3 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.2 mg/kg + Sufentanil 0.4 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.2 mg/kg + Sufentanil 0.5 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.3 mg/kg + Sufentanil 0.1 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.3 mg/kg + Sufentanil 0.2 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.3 mg/kg + Sufentanil 0.3 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.3 mg/kg + Sufentanil 0.4 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.3 mg/kg + Sufentanil 0.5 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.4 mg/kg + Sufentanil 0.1 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.4 mg/kg + Sufentanil 0.2 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.4 mg/kg + Sufentanil 0.3 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.4 mg/kg + Sufentanil 0.4 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.4 mg/kg + Sufentanil 0.5 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.5 mg/kg + Sufentanil 0.1 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.5 mg/kg + Sufentanil 0.2 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.5 mg/kg + Sufentanil 0.3 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.5 mg/kg + Sufentanil 0.4 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.
Eksperimentel: Metoprolol 0.5 mg/kg + Sufentanil 0.5 mcg/kg	Medicin: Sufentanil Sufentanil will be administered intravenously during anesthetic induction at the assigned dose of 0.1, 0.2, 0.3, 0.4, or 0.5 mcg/kg. Each participant will receive sufentanil in combination with the assigned metoprolol dose according to the randomized treatment arm. Medicin: Metoprolol (MET) Metoprolol will be administered intravenously before anesthetic induction at the assigned dose of 0, 0.1, 0.2, 0.3, 0.4, or 0.5 mg/kg. The study drug will be given through a dedicated intravenous catheter, and each participant will receive the dose according to the randomized treatment arm.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Tidsramme
Percentage of participants achieving hemodynamic stability after tracheal intubation Tidsramme: within 0-10 min after intubation	within 0-10 min after intubation

Sekundære resultatmål

Resultatmål	Tidsramme
incidence of bradycardia Tidsramme: within 0-10 min after intubation	within 0-10 min after intubation
incidence of tachycardia Tidsramme: within 0-10 min after intubation	within 0-10 min after intubation
incidence of hypotension Tidsramme: within 0-10 min after intubation	within 0-10 min after intubation
incidence of hypertension Tidsramme: within 0-10 min after intubation	within 0-10 min after intubation

Andre resultatmål

Resultatmål	Tidsramme
adverse event Tidsramme: up to 24 hours postoperatively	up to 24 hours postoperatively

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Fujian Provincial Hospital

Efterforskere

Ledende efterforsker: Yanhua Guo, Fujian Provincial Hospital

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

22. juni 2026

Primær færdiggørelse (Anslået)

22. maj 2027

Studieafslutning (Anslået)

22. maj 2027

Datoer for studieregistrering

Først indsendt

13. maj 2026

Først indsendt, der opfyldte QC-kriterier

13. maj 2026

Først opslået (Faktiske)

19. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

20. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

18. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

K2024-03-015/02

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med General Anesthesia; Tracheal Intubation

Istituto Giannina Gaslini

Ikke rekrutterer endnu

OVERVÅGNING AF NEUROMUSKULÆR BLOK I PÆDIATRISK AÆSTESI (MOTOR)

Neuromuskulær blokade | Tracheal intubation | Anæstesi, general
University Hospital, Geneva

Afsluttet

Prehospital tracheal intubationsteknik ved hjælp af indledende direkte laryngoskopi under videolaryngoskopi

Tracheal intubation

Schweiz
The Hospital for Sick Children

Trukket tilbage

Infant Glidescope® læringskurve

Tracheal intubation

Canada
Hopital Foch

Afsluttet

Vurdering af ETView Double-lumen Tube (ETView1)

Tracheal intubation

Frankrig
Hopital Foch

Afsluttet

Modificerer brugen af et videolaryngoskop anæstetisk induktion? (MGM-PicRemi)

Tracheal intubation

Frankrig
Ann & Robert H Lurie Children's Hospital of Chicago

Afsluttet

KingVision Video laryngoskopi vs direkte laryngoskopi - ækvivalensforsøg

Tracheal intubation

Forenede Stater
Ann & Robert H Lurie Children's Hospital of Chicago

Ukendt

King Vision Video Laryngoscope aBlade vs. Direct Laryngoscopy in Children

Tracheal intubation
The First Affiliated Hospital of Anhui Medical...

Afsluttet

Anvendelsen af Docozine kombineret med Sufentanil til vågen tracheal intubation

Vågen tracheal intubation

Kina
University Hospitals Coventry and Warwickshire...
Oxford University Hospitals NHS Trust

Afsluttet

Patientoplevelse efter vågen fiberoptisk intubation sammenlignet med søvnfiberoptisk intubation

Intubation; Svært | Tracheal intubation

Det Forenede Kongerige
Rigshospitalet, Denmark

Afsluttet

Infrarød gennemlysning af forsiden af halsen (IRRIS)

Tracheal intubation

Danmark

Kliniske forsøg med Sufentanil

University Hospital Hradec Kralove

Afsluttet

ANI og SPI guidet intraoperativ analgesi

Anæstesi

Tjekkiet
Clinical Centre of Serbia

Ikke rekrutterer endnu

Opioid-Free Anesthesia and Pain Study in Cardiac Surgery Patients (OFPAINS-CS)

Posoperativ Pain | Chronich Pain | Postoperativ Delirum | Opoid-free Managment

Serbien
Xiangya Hospital of Central South University

Ikke rekrutterer endnu

Paracetamol og Mannitol Injektion og postoperativt delirium (PAPOD-ES)

Postoperativt delirium | Ældre | Ikke hjertekirurgi

Kina
Groupe Hospitalier de la Region de Mulhouse et...

Trukket tilbage

En ikke-randomiseret, ikke-underlegenheds-sammenlignende undersøgelse af oral Actiskenan (morfin sulfat) versus intranasal sufentanil i den tidlige behandling af svær akut smerte på skadestuer. (SA-URGE)

Svær Akut Smerte

Frankrig
University of Nebraska

Afsluttet

Sufentanil Infusion vs Sufentanil Bolus

Anæstesi

Forenede Stater
AcelRx Pharmaceuticals, Inc.

Afsluttet

Effekt af leveringsvej på PK af Sufentanil NanoTab

Farmakokinetik

Forenede Stater
AcelRx Pharmaceuticals, Inc.

Afsluttet

Effekt- og sikkerhedsforsøg til evaluering af Sufentanil NanoTab® PCA-systemet/15 mcg (Zalviso™) til postoperative smerter hos patienter efter knæ- eller hofteudskiftningskirurgi

Postoperative smerter

Forenede Stater
Tongji Hospital

Ikke rekrutterer endnu

Osellidine anvendes til analgesi under dagtidshysteroskopisk kirurgi

Gynækologisk dagkirurgi
More Foundation

Rekruttering

Forbedring af smertebehandling og reduktion af LOS efter total hoftearthroplastik (THA) og total knæarthroplasty (TKA)

Smerte

Forenede Stater
AcelRx Pharmaceuticals, Inc.

Afsluttet

Et multicenter, randomiseret, dobbeltblindt, placebo-kontrolleret forsøg til evaluering af effektiviteten og sikkerheden af Sufentanil NanoTab PCA-systemet/15 mcg (Zalviso™) til behandling af postoperative smerter hos patienter efter åben abdominal kirurgi

Post-operative smerter

Forenede Stater

Dose-Response Interaction of Metoprolol and Sufentanil for Attenuating Hemodynamic Responses in Tracheal Intubation