Olfactory Dysfunction in Aging Adults
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
Olfactory dysfunction is common in older adults and is associated with impaired quality of life and increased mortality, yet underlying mechanisms and clinically relevant classifications remain poorly defined. Prior studies have relied on limited screening methods and have not adequately characterized the anatomic sites or mechanisms contributing to olfactory loss.
This prospective longitudinal cohort study will enroll adults aged 50 years and older to comprehensively evaluate olfactory function and its determinants. Participants will undergo psychophysical olfactory testing using Sniffin' Sticks (threshold, discrimination, and identification), cognitive assessment, nasal endoscopy, and olfactory mucus collection for biomarker analysis. A subset of participants will also undergo magnetic resonance imaging to assess peripheral and central olfactory structures.
The primary objective is to establish clinically relevant phenotypes of olfactory dysfunction based on olfactory testing and cognitive function, corresponding to peripheral, sensorineural, or central mechanisms. Secondary objectives are to determine the impact of olfactory dysfunction on quality of life, depression, social isolation, and nutrition using validated patient-reported outcome measures, and to identify baseline factors that predict longitudinal changes in olfactory function.
Participants will be followed annually with repeat olfactory testing and outcome assessments to evaluate changes over time and identify predictors of olfactory decline. This study aims to improve understanding of olfactory dysfunction in aging and provide a foundation for future diagnostic and therapeutic strategies.
Undersøgelsestype
Tilmelding (Anslået)
Kontakter og lokationer
Studiekontakt
- Navn: Rodney Schlosser, MD
- Telefonnummer: 18437927165
- E-mail: schlossr@musc.edu
Studiesteder
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South Carolina
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Charleston, South Carolina, Forenede Stater, 29425
- MUSC
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Kontakt:
- Rodney Schlosser, MD
- Telefonnummer: 8437927165
- E-mail: schlossr@musc.edu
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
- Voksen
- Ældre voksen
Tager imod sunde frivillige
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- Age: 50 years or older
- Ability to follow instructions and understand consent process in English
- Adequate visual, auditory, or motor functioning to complete items in the test battery or availability of assistance or assist devices to complete tasks
Exclusion Criteria:
- Vulnerable populations including prisoners or institutionalized individuals
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
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Older Adults With and Without Olfactory Dysfunction
Adults aged 50 years and older enrolled in a prospective cohort study assessing olfactory function, cognition, biomarkers, and quality of life, with annual follow-up.
Participants will be classified post hoc into olfactory phenotypes based on testing results.
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Participants undergo olfactory testing (Sniffin' Sticks), cognitive assessment, nasal endoscopy, olfactory mucus collection, MRI imaging (subset), and patient-reported outcome measures to evaluate olfactory function, biomarkers, and health outcomes over time.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Olfactory Function
Tidsramme: Baseline
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Olfactory Threshold, Discrimination, and Identification (TDI scores) using Sniffin' Sticks.
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Baseline
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
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Change in Olfactory Function Over Time
Tidsramme: Year 1 and year 2
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Longitudinal assessment of changes in olfactory function to identify decline over time.. Change in TDI scores (threshold, discrimination, identification)
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Year 1 and year 2
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Patient-Reported Outcomes
Tidsramme: Baseline, Year 1 and year 2
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Patient-reported measure assessing quality of life using QOD questionnaire.
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Baseline, Year 1 and year 2
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Samarbejdspartnere og efterforskere
Samarbejdspartnere
Publikationer og nyttige links
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- Pro00150356
- 5R01DC019078-05 (U.S. NIH-bevilling/kontrakt)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
IPD-planbeskrivelse
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
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