A Study of a New Asthma Medicine in Asthmatics Whose Asthma Worsens With Exercise

Inclusion Criteria:

• Outpatient male or female 12 to 50 years of age
• Females of child-bearing potential must be willing to use birth control or commit to abstinence during the study
• Diagnosis of persistent asthma for at least 6 months
• Best pre-bronchodilator FEV1 of at least 70%.
• Current use of a low- to moderate-dose inhaled corticosteroid
• Ability to withhold albuterol 6 hours prior to visits.
• Physically able to perform exercise testing on a treadmill when albuterol has been withheld

Exclusion Criteria:

• Intermittent asthma, seasonal asthma, or exercise-induced asthma only
• Symptomatic allergic rhinitis and/or thrush
• Abnormal, clinically significant electrocardigraph
• Respiratory infection within 4 weeks of first visit leading to asthma medication change or could affect subjects's asthma status or participation
• Asthma exacerbation within 12 weeks of first visit
• Respiratory diseases or other concurrent disease that would put subject at risk or confound results interpretation
• Investigational medicines within 30 days of first visit or less than five half-lives of medication in prior study
• Allergy to study drugs or study drug excipients
• Concomitant medications that could interact with study medications or affect the course of asthma
• Tobacco use within last year and/or a 10 pack-years history
• Inability to comply with requirements of the study
• Affiliation with investigator's site (example: family member)