- ICH GCP
- Registro de ensayos clínicos de EE. UU.
- Ensayo clínico NCT04707430
The Effect of Progesterone Levels on Pregnancy
The Effect of Progesterone Levels on the 3rd and 5th Days After Insemination on Pregnancy
Descripción general del estudio
Estado
Intervención / Tratamiento
Descripción detallada
Ovarian stimulation with gonadotropins is a frequently used method in patients with unexplained infertility undergoing intrauterine insemination.
Pregnancy and live birth rates after ovarian stimulation; The number of follicles in ovulatory size and responsive to ovarian stimulation is affected by many factors such as the age of the woman and the duration of infertility. Progesterone production in the luteal phase is necessary to achieve successful treatment results by increasing the receptivity of the endometrium in the secretory phase.
In assisted reproductive techniques, exogenous progesterone support in the luteal phase is a routinely used method due to higher pregnancy rates, but there is no consensus with the use of progesterone in IUI applications. In a recent meta-analysis, a positive relationship was found between gonadotropins and progesterone support when ovulation induction and intrauterine insemination were performed, while this relationship was not found with clomiphene citrate, and although letrozole and gonadotropin were used together, no significant statistics were found.
The relationship between luteal phase hormone dynamics and pregnancy outcomes in IUI is not fully understood. Although luteal phase failure is mentioned, there is no accepted definition of luteal phase failure worldwide. In one study, progesterone concentrations in the midluteal phase and pregnancy outcomes were investigated in 188 IUI cycles, predicting that low levels could predict treatment failure. In another study, a positive relationship was found between luteal phase progesterone levels and clinical pregnancy outcomes.However, the relationship between blood progesterone levels and pregnancy rates in a small number of IUI cycles has been investigated in the literature. Considering all these studies, there is no Level 1 evidence regarding the benefit of providing progesterone support in groups where the progesterone level is below a certain threshold value. In this study, we aimed to investigate the relationship between gestational outcomes by looking at progesterone values on the 3rd and 5th days after IUI in patients who were decided to be treated with IUI. By looking at these progesterone levels, we aimed to determine a threshold value for the ideal level of progesterone in the luteal phase and to be a guide in terms of possible results and methods of shaping the treatment.
Tipo de estudio
Inscripción (Actual)
Contactos y Ubicaciones
Ubicaciones de estudio
-
-
-
Ankara, Pavo
- Hacettepe University
-
-
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Patients who have been decided for intrauterine insemination
- Patients under the age of 40
- Patients with a BMI of less than 40 kg / m2
- Cycles triggered by rhCG
- Those who have a signed and dated informed consent document that they have been informed about the study and that their consent has been obtained
Exclusion Criteria:
- Patients over the age of 40
- Patients with BMI over 40 kg / m2
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
The progesterone level
Periodo de tiempo: up to 12 months
|
the effect of progesterone levels 3rd and 5th day after insemination on ongoing pregnancy
|
up to 12 months
|
Colaboradores e Investigadores
Patrocinador
Investigadores
- Silla de estudio: Gurkan Bozdag, Prof., Hacettepe University
- Silla de estudio: Galip Serdar Gunalp, Prof., Hacettepe University
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- HU1101
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .
Ensayos clínicos sobre blood progesterone test
-
University Hospital, RouenAún no reclutandoHepatitis B | Hepatitis C | SIDAFrancia
-
Haydarpasa Numune Training and Research HospitalTerminadoDesorden sangrantePavo
-
Smiths Medical, ASD, Inc.Terminado
-
University of MiamiUniversity of Tennessee Health Science CenterTerminadoObesidad | Actividad física | Función Cognitiva 1, SocialEstados Unidos
-
Methodist Health SystemTerminado
-
GRAIL, LLCCancer Research UK and King's College London Cancer Prevention Trials Unit...Activo, no reclutando
-
Suleyman Demirel UniversityTerminadoEstudiantes de EnfermeríaPavo
-
University of LeedsTerminadoHiperglucemiaReino Unido
-
Applied Science & Performance InstituteTerminadoDeficiencia de hierro (sin anemia)Estados Unidos
-
Istinye UniversityInscripción por invitaciónCarrera | Tele-evaluación | La prueba Timed Up & Go | Prueba de soporte de silla de 30 segundosPavo