Local Infiltration With Ropivacaine Improves Postoperative Pain Control in Patients

Inclusion Criteria:

• Female or male, and any race, Age≥18 years at the screening visite.
• ASA physical status I to II.
• Scheduled to undergo laparoscopic cholecystectomy under general anesthesia.
• Famale subjects must be without pregnancy.
• Ability to provide informed consent, adhere to the study visite schedule, and complete all study assessments.

Exclusion Criteria:

• Boss mass index >35kg/㎡
• Under intravertebral anesthesia and/or epidural analgesia
• Under postoperatived patient-controlled epidural analgesia (PCEA) and postoperative intravenous analgesia(PCIA).
• Inability to understand and use the visual analog scale (VAS)
• Currently pregnant,nursing,or planning to become pregnant during the study or within one month after study drug administration.
• Chronic user of analgesic medications, including taking opioid medications for more than 14 days in the last 3months,or non-opioid pain medications more than 5 times per week.
• Proven or suspected allergy to local anesthetics ,NSAIDs and opioids .
• Use of any NSAIDs including selective COX-2 inhibitor , opioids or other analgesic agents within 3days of surgery.
• History of suspected or known addiction to or abuse of drugs or alcohol within the past 2 years.
• Current acute or chronic medical or major psychiatric disease that,in the opinion of the investigator ,would interfere with the evaluation of study drug efficacy or safety.
• Any other subjects were not suitable to this study in the opinion of the investigator.