Effects of a 10 Component Dietary Supplement on Health and the Quality of Life
Effects of a Multi-Pathway Dietary Supplement (Stem Cell 100+) on Indices of Health and Life Expectancy
調査の概要
状態
詳細な説明
Currently, only dietary restriction has been verified to slow the rate of aging and to promote general health. This trial is designed to see whether a complex supplement (Stem Cell 100+) that targets multiple longevity pathways could also have positive effects on several markers of successful aging and good health. Multipath causes of aging include: stem cell function, telomere loss, chronic stress, inflammation, insulin-like growth factors, autophagy, vascular loss, neural dysfunction, and oxidative stress. The goal of the study was to test the effects of this novel multipath intervention strategy in a clinical trial of healthy people using health markers such as blood pressure, cholesterol status, lung function, stress levels, and self-reported health status. Hundreds of published animal and human clinical studies have been done with each of the individual active ingredients in the formulation, which target many critical causes of aging.
Based on their published animal studies showing extension of life span in a model animal and their laboratory work on adult human stem cells, the investigators believe that Stem Cell 100+ will provide evidence of efficacy in addressing multiple index markers of health and life expectancy outcomes.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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California
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San Diego、California、アメリカ、92121
- Accelagen, Inc.
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- No history of serious cardiovascular, cancer, or neural disease.
- Normal health for age
- Willing to have blood drawn at baseline and after trial
- Willing to submit to evaluation testing of blood pressure, lung testing, stress testing.
- Willing to take online self reported survey of health at end of trial
Exclusion Criteria:
- History of metastatic cancer, heart attack, dementia, or other life-threatening disease
- Any subject who is not capable of responding to a self-reported online questionnaire
- Pregnant
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:防止
- 割り当て:なし
- 介入モデル:単一グループの割り当て
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的:Stem Cell 100+ Intervention
Subjects take one 650 mg capsule by mouth twice daily for an average of 15 weeks
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Open-Label 10-Component Dietary Supplement
他の名前:
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Blood Pressure
時間枠:Baseline and at an average of 15 weeks
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Change in Systolic and Diastolic Blood Pressure
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Baseline and at an average of 15 weeks
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HDL Cholesterol
時間枠:Baseline and at an average of 15 weeks
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Change in HDL Cholesterol
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Baseline and at an average of 15 weeks
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Lung Capacity
時間枠:Baseline and at an average of 15 weeks
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Change in Peak Expiatory Flow
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Baseline and at an average of 15 weeks
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Stress Level
時間枠:Baseline and at an average of 15 weeks
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Change in Heart Rate Variability
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Baseline and at an average of 15 weeks
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Heart Rate
時間枠:Baseline and at an average of 15 weeks
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Change in Heart Rate
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Baseline and at an average of 15 weeks
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
---|---|---|
Overall Health
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Ability to Concentrate or Focus
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Joint Flexibility
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Work Productivity
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Ability to Relax
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Cold/Flu Resistance
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Stress Tolerance
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Energy Level
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Endurance
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Ease of Walking
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Climbing Stairs
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Overall Mood
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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Vitality
時間枠:From baseline through study completion, an average of 15 weeks
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Self-Reported Change based on a 7 point range from Much Better (+3) to Much Worse (-3)
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From baseline through study completion, an average of 15 weeks
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協力者と研究者
スポンサー
捜査官
- 主任研究者:Bryant Villeponteau, Ph.D.、Centagen, Inc.
出版物と役立つリンク
一般刊行物
- Villeponteau B, Matsagas K, Nobles AC, Rizza C, Horwitz M, Benford G, Mockett RJ. Herbal supplement extends life span under some environmental conditions and boosts stress resistance. PLoS One. 2015 Apr 16;10(4):e0119068. doi: 10.1371/journal.pone.0119068. eCollection 2015.
- Villeponteau B, Cockrell R, Feng J. Nutraceutical interventions may delay aging and the age-related diseases. Exp Gerontol. 2000 Dec;35(9-10):1405-17. doi: 10.1016/s0531-5565(00)00182-0.
- Villeponteau B. The heterochromatin loss model of aging. Exp Gerontol. 1997 Jul-Oct;32(4-5):383-94. doi: 10.1016/s0531-5565(96)00155-6.
- Marusic L, Anton M, Tidy A, Wang P, Villeponteau B, Bacchetti S. Reprogramming of telomerase by expression of mutant telomerase RNA template in human cells leads to altered telomeres that correlate with reduced cell viability. Mol Cell Biol. 1997 Nov;17(11):6394-401. doi: 10.1128/MCB.17.11.6394.
- Harley CB, Villeponteau B. Telomeres and telomerase in aging and cancer. Curr Opin Genet Dev. 1995 Apr;5(2):249-55. doi: 10.1016/0959-437x(95)80016-6.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
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