Positron Emission Tomography Imaging of Brain Reorganisation of the Central Auditory Cortex in Asymetrical Profound Deaf Patient With a Cochlear Implantation. (UniTEP)
Positron Emission Tomography Imaging of Brain Reorganisation of the Central Auditory Cortex in Asymetrical Profound Deaf Patient With a Cochlear Implantation
調査の概要
詳細な説明
Cochlear implantation is the most efficient method to restore hearing in deaf patients. However, about 2/3 of patients have some residual hearing and these patients usually combine two types of auditory information (electrical and acoustical). It is important to know how the brain is processing during two distinct stimulations and how it is related to the auditory level of performance.
Patients and controls will undergo a positron emission tomography scan brain imaging session during a simplified voice/non-voice discrimination task. For each tasks and brain imaging sessions, patients will be stimulated either with the non-implanted ear (acoustical stimulation), the cochlear implant (electrical stimulation) and using both modalities in a binaural condition.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Toulouse、フランス、31059
- CHU de Toulouse - Hôpital Purpan
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Midi-Pyrénées
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Toulouse、Midi-Pyrénées、フランス、31052
- CERCO
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- cochlear implantation>3 months
- signature of informed consent
- affiliation to social service.
Exclusion Criteria:
- associated neurological disorder
- protected subjects
- epilepsy episodes
- psychotropic medication
- pregnancy
研究計画
研究はどのように設計されていますか?
デザインの詳細
- 主な目的:基礎科学
- 割り当て:非ランダム化
- 介入モデル:並列代入
- マスキング:なし(オープンラベル)
武器と介入
参加者グループ / アーム |
介入・治療 |
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他の:Asymmetric hearing loss
Asymmetric hearing loss treated with a cochlear implant will undergo positron emission tomography scan.
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他の:Normal hearing subjects
Normal hearing subjects will undergo positron emission tomography scan.
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この研究は何を測定していますか?
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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Differences in auditory brain activation between cochlear implanted asymmetric hearing loss subjects and normal hearing subjects in the binaural condition.
時間枠:Day 1
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Prior to the imaging session, patients performed two human voice interpretation tests.
link between temporal activations and performances obtained in binaural integration tasks in the patient group.
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Day 1
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
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differences in auditory brain activation.
時間枠:Week 3 - Week 5
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Auditory brain activation when the better ear is acoustically stimulated in asymmetric hearing loss subjects and when one ear is stimulated in normal hearing subjects.
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Week 3 - Week 5
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Performance level and the pattern of brain activation.
時間枠:Week 3 - Week 5
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Acoustical or electrical stimulation in asymmetric hearing loss cochlear implanted subjects.
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Week 3 - Week 5
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the asymmetry in auditory brain activation for asymmetric hearing loss cochlear implanted subjects.
時間枠:Week 3 - Week 5
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Electrical and acoustical stimulation will be used.
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Week 3 - Week 5
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link between binaural hearing performances and auditory brain activation in the binaural condition.
時間枠:Week 3 - Week 5
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For the group of cochlear implanted subjects with asymmetric hearing loss.
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Week 3 - Week 5
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協力者と研究者
捜査官
- 主任研究者:Mathieu Marx, Pr、CHU Toulouse
出版物と役立つリンク
一般刊行物
- Strelnikov K, Rouger J, Demonet JF, Lagleyre S, Fraysse B, Deguine O, Barone P. Visual activity predicts auditory recovery from deafness after adult cochlear implantation. Brain. 2013 Dec;136(Pt 12):3682-95. doi: 10.1093/brain/awt274. Epub 2013 Oct 17.
- Vannson N, James C, Fraysse B, Strelnikov K, Barone P, Deguine O, Marx M. Quality of life and auditory performance in adults with asymmetric hearing loss. Audiol Neurootol. 2015;20 Suppl 1:38-43. doi: 10.1159/000380746. Epub 2015 May 19.
- Deggouj N, Gersdorff M, Garin P, Castelein S, Gerard JM. Today's indications for cochlear implantation. B-ENT. 2007;3(1):9-14.
- Devocht EM, Dees G, Arts RA, Smits JJ, George EL, van Hoof M, Stokroos RJ. Revisiting Place-Pitch Match in CI Recipients Using 3D Imaging Analysis. Ann Otol Rhinol Laryngol. 2016 May;125(5):378-84. doi: 10.1177/0003489415616130. Epub 2015 Dec 1.
- Shannon RV, Zeng FG, Kamath V, Wygonski J, Ekelid M. Speech recognition with primarily temporal cues. Science. 1995 Oct 13;270(5234):303-4. doi: 10.1126/science.270.5234.303.
- Fu QJ, Shannon RV, Wang X. Effects of noise and spectral resolution on vowel and consonant recognition: acoustic and electric hearing. J Acoust Soc Am. 1998 Dec;104(6):3586-96. doi: 10.1121/1.423941.
- Munson B, Nelson PB. Phonetic identification in quiet and in noise by listeners with cochlear implants. J Acoust Soc Am. 2005 Oct;118(4):2607-17. doi: 10.1121/1.2005887.
- Rouger J, Lagleyre S, Fraysse B, Deneve S, Deguine O, Barone P. Evidence that cochlear-implanted deaf patients are better multisensory integrators. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7295-300. doi: 10.1073/pnas.0609419104. Epub 2007 Apr 2.
- Rouger J, Fraysse B, Deguine O, Barone P. McGurk effects in cochlear-implanted deaf subjects. Brain Res. 2008 Jan 10;1188:87-99. doi: 10.1016/j.brainres.2007.10.049. Epub 2007 Oct 26.
- Marx M, James C, Foxton J, Capber A, Fraysse B, Barone P, Deguine O. Speech prosody perception in cochlear implant users with and without residual hearing. Ear Hear. 2015 Mar-Apr;36(2):239-48. doi: 10.1097/AUD.0000000000000105.
- Strelnikov K, Rouger J, Demonet JF, Lagleyre S, Fraysse B, Deguine O, Barone P. Does brain activity at rest reflect adaptive strategies? Evidence from speech processing after cochlear implantation. Cereb Cortex. 2010 May;20(5):1217-22. doi: 10.1093/cercor/bhp183. Epub 2009 Oct 5.
- Strelnikov K, Rouger J, Lagleyre S, Fraysse B, Demonet JF, Deguine O, Barone P. Increased audiovisual integration in cochlear-implanted deaf patients: independent components analysis of longitudinal positron emission tomography data. Eur J Neurosci. 2015 Mar;41(5):677-85. doi: 10.1111/ejn.12827.
- Rouger J, Lagleyre S, Demonet JF, Fraysse B, Deguine O, Barone P. Evolution of crossmodal reorganization of the voice area in cochlear-implanted deaf patients. Hum Brain Mapp. 2012 Aug;33(8):1929-40. doi: 10.1002/hbm.21331. Epub 2011 May 6.
- Giraud AL, Truy E, Frackowiak RS, Gregoire MC, Pujol JF, Collet L. Differential recruitment of the speech processing system in healthy subjects and rehabilitated cochlear implant patients. Brain. 2000 Jul;123 ( Pt 7):1391-402. doi: 10.1093/brain/123.7.1391.
- Giraud AL, Price CJ, Graham JM, Truy E, Frackowiak RS. Cross-modal plasticity underpins language recovery after cochlear implantation. Neuron. 2001 Jun;30(3):657-63. doi: 10.1016/s0896-6273(01)00318-x.
- Scheffler K, Bilecen D, Schmid N, Tschopp K, Seelig J. Auditory cortical responses in hearing subjects and unilateral deaf patients as detected by functional magnetic resonance imaging. Cereb Cortex. 1998 Mar;8(2):156-63. doi: 10.1093/cercor/8.2.156.
- Ponton CW, Vasama JP, Tremblay K, Khosla D, Kwong B, Don M. Plasticity in the adult human central auditory system: evidence from late-onset profound unilateral deafness. Hear Res. 2001 Apr;154(1-2):32-44. doi: 10.1016/s0378-5955(01)00214-3.
- Massida Z, Belin P, James C, Rouger J, Fraysse B, Barone P, Deguine O. Voice discrimination in cochlear-implanted deaf subjects. Hear Res. 2011 May;275(1-2):120-9. doi: 10.1016/j.heares.2010.12.010. Epub 2010 Dec 16.
- Guerreiro MJ, Erfort MV, Henssler J, Putzar L, Roder B. Increased visual cortical thickness in sight-recovery individuals. Hum Brain Mapp. 2015 Dec;36(12):5265-74. doi: 10.1002/hbm.23009. Epub 2015 Sep 29.
- Collett E, Marx M, Gaillard P, Roby B, Fraysse B, Deguine O, Barone P. Categorization of common sounds by cochlear implanted and normal hearing adults. Hear Res. 2016 May;335:207-219. doi: 10.1016/j.heares.2016.03.007. Epub 2016 Apr 2.
- Strelnikov K, Rouger J, Lagleyre S, Fraysse B, Deguine O, Barone P. Improvement in speech-reading ability by auditory training: Evidence from gender differences in normally hearing, deaf and cochlear implanted subjects. Neuropsychologia. 2009 Mar;47(4):972-9. doi: 10.1016/j.neuropsychologia.2008.10.017. Epub 2008 Oct 30.
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Positron emission tomography scanの臨床試験
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Emory UniversityNational Cancer Institute (NCI); Blue Earth Diagnostics積極的、募集していない