- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT02881047
Ablative Fractional Laser for Sclerotic GVHD-Associated Joint Contractures
6. april 2020 oppdatert av: Abramson Cancer Center of the University of Pennsylvania
Ablative Fractional Laser Resurfacing for the Treatment of Scars and Contractures Caused by Sclerotic Skin Changes Chronic Graft Versus Host Disease
Graft versus host disease (GVHD) is a common complication of allogeneic stem cell transplant.Chronic GVHD is characterized by skin thickening and tightening.
Advanced sclerosis can lead to reduced range of motion and incapacitating joint contractures.
Once present, there are few therapeutic options.
We will treat sclerosis and limb contractures with an ablative fractional laser, a device FDA-approved for scar treatment.
This approach has successfully treated contracturesdue to burn scars.
Studieoversikt
Status
Avsluttet
Intervensjon / Behandling
Studietype
Intervensjonell
Registrering (Faktiske)
8
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Pennsylvania
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Philadelphia, Pennsylvania, Forente stater, 19104
- Abramson Cancer Center of the University of Pennsylvania
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
- Subjects must be able to give informed consent
- All adult patients (18 years of age or older) Severe sclerotic skin changes of chronic graft versus host disease meeting a score of 3 on the NIH consensus criteria for organ scoring of chronic GVHD,
- a score defined by deep sclerotic features with hidebound skin which cannot be pinched together, resulting in impaired motion.
- According to the NIH criteria, the patient need not have widespread cutaneous GVHD; hidebound skin OR impaired mobility receive a score of 3 (highest score).
- Demonstrable range of motion limitations and joint contractures due to sclerotic GVHD across a specific joint / limb amenable to laser therapy must be present. - - Patients must note an inability to bend the joint (e.g. foot, wrist, elbow) freely which compromises the ability to perform specific tasks (e.g. walking up or down stairs, grabbing / making a fist, lifting or raising thearms over the head). As these functional limitations are by their nature subjective (and NIH scoring criteria are themselves subjective) determination of eligibility will be made by the investigator.
- ECOG Performance Status shall be 0-3
Exclusion Criteria:
- Persons unable to provide informed consent Pregnant or nursing women, or children under age 18
- Active infections such as herpes simplex virus (HSV) Acute, untreated medical problems such as poorly-controlled diabetes, decompensated heart failure, etc.
- There are no specific contraindications to use of the laser based on skin pigmentation, sun sensitivity, history of keloids, use of specific medications, etc.
- Appropriateness for trial entry will be determined on an individual basis by the study investigators.
- Patients with ECOG Performance Status 3 will be excluded.
- Patients with ANC 1500,PLT 50, or Hgb 8.0 will be excluded.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Støttende omsorg
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
---|---|
Eksperimentell: rAblative Fractional Laser for Sclerotic GVHD-Associated Joint
Range of motion limitations and joint contractures due to sclerotic GVHD across a specific joint / limb"
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Perform ablative fractional resurfacing using a 10,600nm carbon dioxide (CO2) laser targeted to thickened, sclerotic plaques causing range of motion limitation and contracture across joints.
Patients will undergo ultrasound of the planned treatment site to measure skin thickness and blood flow via Doppler ultrasound.
standard 4mm punch biopsy of the skin at the planned treatment site for histologic assessment of skin thickness and sclerosis.
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Number of Subjects Who Show Improvement in Range of Motion, Flexion, and Extension
Tidsramme: 5 months from time point zero / baseline
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Range of motion (flexion, extension, supination, pronation) of the target joint (measured in degrees, using a goniometer).
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5 months from time point zero / baseline
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Number of Subjects With Evidence of Collagen Remodeling (Increased Dermal Echogenicity) Compared to Baseline
Tidsramme: 3 months after final laser session (5 months after time zero / baseline)
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Measurement of skin echogencity (brightness) in comparison with pre-therapy images of the same areas using high-resolution ultrasound.
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3 months after final laser session (5 months after time zero / baseline)
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Number of Subjects Who Show Decrease in Skin Thickness and Sclerosis With Collagen Remodeling as Measured by Before and After Skin Biopsies Biopsy
Tidsramme: baseline and 3 months after final laser session
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Trichcrome stain, collagen fiber number and thickness, Herovici stain, elastic fiber length, and dermal thickness.
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baseline and 3 months after final laser session
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Etterforskere
- Hovedetterforsker: Robert Micheletti, MD, Abramson Cancer Center of the University of Pennsylvania
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
11. november 2013
Primær fullføring (Faktiske)
1. august 2016
Studiet fullført (Faktiske)
19. august 2016
Datoer for studieregistrering
Først innsendt
24. august 2016
Først innsendt som oppfylte QC-kriteriene
24. august 2016
Først lagt ut (Anslag)
26. august 2016
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
16. april 2020
Siste oppdatering sendt inn som oppfylte QC-kriteriene
6. april 2020
Sist bekreftet
1. april 2020
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- UPCC 14613
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
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