Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe Asthma

inclusion criteria: healthy control group：

• Mainly from students,
• family members of patients without chronic lung disease,
• healthy population,
• age 18-75 years old, the gender is not limited. case group：
• The patient has been diagnosed with asthma in the outpatient clinic. The diagnostic criteria are in accordance with the Guidelines for Prevention and Treatment of Bronchial Asthma in the respiratory disease branch of the Chinese Medical Association.

In the past 1 year need guidelines of global asthma record instrument 4-5 drug treatment of asthma [high dose inhaled corticosteroid with long-acting beta2 receptor agonist or leukotriene modifiers / theophylline or systemic hormone therapy is more than or equal to 50% of the time, in order to prevent into uncontrolled asthma, or even in the treatment is to control asthma patients for severe asthma.

exclusion criteria：

• Poor treatment compliance, or low cognitive ability to impact the self rating scale ;
• There are serious heart, liver, renal dysfunction, or other infectious diseases ;
• The individual who refuse to sign the informed consent.