A Study the Population Pharmacokinetics of Children of Infectious Disease in Central Nervous System

Inclusion Criteria:

• Children (29 days-18 years old) with anti-infective therapy against infectious disease in central nervous system.
• Clinical symptoms: acute onset, fever (axillary temperature 38 ℃ or higher), headache, altered level of consciousness, vomiting, irritability, sleepiness, low muscle tone, seizures, before the fontanelle full or uplift, positive meningeal stimulation;
• Aboratory examination: CSF appearance change, CSF routine WBC >100 per ml, CSF routine WBC 10-100 per ml, glucose <40mg/dl, protein >100mg/dl), positive detection of etiology (bacterial culture, antigen detection, gram staining).

Exclusion Criteria:

• autoimmune encephalitis;
• central nervous system infection complicated with tumor;
• allergic to carbapenems or glycopeptide antibiotics;
• other cases not suitable for enrollment (small sample size, incomplete clinical data, etc.).