缩窄性心包炎诊断的间隔移位:吸气努力量化对深呼吸操作的影响 (SCOPED)
缩窄性心包炎诊断的间隔移位:吸气努力量化对深呼吸动作的影响 (SCOPED)
This study will evaluate the effect of deep breathing manoeuvres on inter ventricular interdependency physiology. By providing further insight in this basic physiology we want to add more comprehensive data in favor or not of constrictive pericarditis diagnostic criteria currently used in cardiovascular magnetic resonance.
研究概览
研究类型
注册 (实际的)
联系人和位置
学习地点
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Quebec
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Sherbrooke、Quebec、加拿大、J1H 5N4
- Paul
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
Population consists of healthy subjects not know for any cardiovascular disease.
描述
Inclusion Criteria:
- Men and women between 18 and 80 years old
- Normal transthoracic echocardiogram if older than 41 years old
- Normal standardized history and physical examination
- Normal blood pressure (<130/80)
- Normal 12-lead ECG at rest.
Exclusion Criteria:
- No prior pulmonary or cardiac diseases
- Unexplained symptoms that could be related to a heart or pulmonary problems.
- Symptoms of or active cardiovascular or pulmonary problems
- Hepatic or kidney dysfunction
- Blood cell dyscrasia
- Cardiovascular risk factor (smoking, hypertension, dyslipidemia, diabetes)
- Obesity (BMI > 30)
- Pregnancy or pregnancy in the last year
- Cardiac congenital anomalies discovered during the cardiovascular magnetic resonance
- Current medication with cardiovascular side effects known (diuretics, beta-blockers, calcium channel blockers)
- Contraindication to cardiovascular magnetic resonance
学习计划
研究是如何设计的?
设计细节
- 观测模型:CASE_ONLY
- 时间观点:PROSPECTIVE
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Breathing effort type
Current known criteria for constrictive pericarditis will be test under: 1- spontaneous breathing 2- Breathing with a negative pressure of -15 to - 30 cm of water 3- Breathing with a negative pressure of more than - 30 cm of water. |
Subjects will have to breath 1- Spontaneously 2- to produce a negative pressure of -15 to -30 cm of water and 3- to produce a negative pressure more than -30 cm of water. |
研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Measurement of the interventricular septum position between inspiration and expiration as assessed by CMR.
大体时间:Immediate
|
Analysis of respiratory-related septal excursion. The relative position of the septum can be obtained by dividing the distance between RV free wall and septum by the biventricular distance. If done during inspiration and expiration, at early ventricular filling, the respiratory-related septal excursion can be quantified. |
Immediate
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Presence or absence (categorical variable) of a diastolic bounce as assessed by CMR.
大体时间:Immediate
|
Diastolic bounce corresponds to a displacement of inter ventricular septum towards de left ventricle during the protodiastolic period. |
Immediate
|
|
Measurement of the variation of flow through the mitral and tricuspid valve between inspiration and expiration as assessed by CMR.
大体时间:Immediate
|
Real-Time Phase-Contrast acquisition using a custom-made sequence with through-plane velocity encoding to simultaneously measure MV and TV inflow velocities by prescribing a slice position across both atrioventricular valves from a horizontal long-axis view. |
Immediate
|
|
Biventricular Index: measurement of the heart contour between inspiration and expiration as assessed by CMR.
大体时间:Immediate
|
Short axis cross section through the mid ventricle. The epicardial tracings is performed in end expiration and end inspiration. The end inspiratory epicardial tracing is divided by the end expiratory epicardial tracing to obtain the biventricular index |
Immediate
|
|
Presence or absence (categorical variable) of diastolic flow reversal in inferior vein cave as assessed by cardiovascular magnetic resonance (CMR).
大体时间:Immediate
|
Real-time cine imaging of the inferior vein cave for 10 s |
Immediate
|
|
Presence or Absence of lack of myocardial slippage in relation to the pericardium as assessed by CMR (tagging sequence)
大体时间:Immediate
|
Four-chamber tagged cardiac magnetic resonance image showing lack of slippage between parietal and visceral pericardia. The tag lines break between parietal and visceral pericardia during the cardiac cycle in a normal heart. In constrictive pericarditis, the tag lines do not break. |
Immediate
|
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Measurement of the relative atrial volume ratio as assessed by CMR.
大体时间:Immediate.
|
The relative atrial volume ratio (RAR) is defined as the left auricular (LA) volume divided by right auricular (RA) volume. For the LA volume, the biplane area- length method will be used. For the RA volume, the monoplane area-length formula will be used. |
Immediate.
|
合作者和调查者
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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