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缩窄性心包炎诊断的间隔移位:吸气努力量化对深呼吸操作的影响 (SCOPED)

2026年11月9日 更新者:Paul Farand、Université de Sherbrooke

缩窄性心包炎诊断的间隔移位:吸气努力量化对深呼吸动作的影响 (SCOPED)

This study will evaluate the effect of deep breathing manoeuvres on inter ventricular interdependency physiology. By providing further insight in this basic physiology we want to add more comprehensive data in favor or not of constrictive pericarditis diagnostic criteria currently used in cardiovascular magnetic resonance.

研究概览

地位

终止

研究类型

观察性的

注册 (实际的)

3

联系人和位置

本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。

学习地点

    • Quebec
      • Sherbrooke、Quebec、加拿大、J1H 5N4
        • Paul

参与标准

研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 80年 (成人、年长者)

接受健康志愿者

是的

有资格学习的性别

全部

取样方法

非概率样本

研究人群

Population consists of healthy subjects not know for any cardiovascular disease.

描述

Inclusion Criteria:

  • Men and women between 18 and 80 years old
  • Normal transthoracic echocardiogram if older than 41 years old
  • Normal standardized history and physical examination
  • Normal blood pressure (<130/80)
  • Normal 12-lead ECG at rest.

Exclusion Criteria:

  • No prior pulmonary or cardiac diseases
  • Unexplained symptoms that could be related to a heart or pulmonary problems.
  • Symptoms of or active cardiovascular or pulmonary problems
  • Hepatic or kidney dysfunction
  • Blood cell dyscrasia
  • Cardiovascular risk factor (smoking, hypertension, dyslipidemia, diabetes)
  • Obesity (BMI > 30)
  • Pregnancy or pregnancy in the last year
  • Cardiac congenital anomalies discovered during the cardiovascular magnetic resonance
  • Current medication with cardiovascular side effects known (diuretics, beta-blockers, calcium channel blockers)
  • Contraindication to cardiovascular magnetic resonance

学习计划

本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。

研究是如何设计的?

设计细节

  • 观测模型:CASE_ONLY
  • 时间观点:PROSPECTIVE

队列和干预

团体/队列
干预/治疗
Breathing effort type

Current known criteria for constrictive pericarditis will be test under: 1- spontaneous breathing 2- Breathing with a negative pressure of -15 to - 30 cm of water 3- Breathing with a negative pressure of more than - 30 cm of water.

Subjects will have to breath 1- Spontaneously 2- to produce a negative pressure of -15 to -30 cm of water and 3- to produce a negative pressure more than -30 cm of water.

研究衡量的是什么?

主要结果指标

结果测量
措施说明
大体时间
Measurement of the interventricular septum position between inspiration and expiration as assessed by CMR.
大体时间:Immediate

Analysis of respiratory-related septal excursion. The relative position of the septum can be obtained by dividing the distance between RV free wall and septum by the biventricular distance. If done during inspiration and expiration, at early ventricular filling, the respiratory-related septal excursion can be quantified.

Immediate

次要结果测量

结果测量
措施说明
大体时间
Presence or absence (categorical variable) of a diastolic bounce as assessed by CMR.
大体时间:Immediate

Diastolic bounce corresponds to a displacement of inter ventricular septum towards de left ventricle during the protodiastolic period.

Immediate
Measurement of the variation of flow through the mitral and tricuspid valve between inspiration and expiration as assessed by CMR.
大体时间:Immediate

Real-Time Phase-Contrast acquisition using a custom-made sequence with through-plane velocity encoding to simultaneously measure MV and TV inflow velocities by prescribing a slice position across both atrioventricular valves from a horizontal long-axis view.

Immediate
Biventricular Index: measurement of the heart contour between inspiration and expiration as assessed by CMR.
大体时间:Immediate

Short axis cross section through the mid ventricle. The epicardial tracings is performed in end expiration and end inspiration. The end inspiratory epicardial tracing is divided by the end expiratory epicardial tracing to obtain the biventricular index

Immediate
Presence or absence (categorical variable) of diastolic flow reversal in inferior vein cave as assessed by cardiovascular magnetic resonance (CMR).
大体时间:Immediate

Real-time cine imaging of the inferior vein cave for 10 s

Immediate
Presence or Absence of lack of myocardial slippage in relation to the pericardium as assessed by CMR (tagging sequence)
大体时间:Immediate

Four-chamber tagged cardiac magnetic resonance image showing lack of slippage between parietal and visceral pericardia. The tag lines break between parietal and visceral pericardia during the cardiac cycle in a normal heart. In constrictive pericarditis, the tag lines do not break.

Immediate
Measurement of the relative atrial volume ratio as assessed by CMR.
大体时间:Immediate.

The relative atrial volume ratio (RAR) is defined as the left auricular (LA) volume divided by right auricular (RA) volume. For the LA volume, the biplane area- length method will be used. For the RA volume, the monoplane area-length formula will be used.

Immediate.

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始

2016年9月1日

初级完成 (实际的)

2020年2月1日

研究完成 (实际的)

2020年2月1日

研究注册日期

首次提交

2016年1月13日

首先提交符合 QC 标准的

2016年2月12日

首次发布 (估计的)

2016年2月18日

研究记录更新

最后更新发布 (实际的)

2026年11月13日

上次提交的符合 QC 标准的更新

2026年11月9日

最后验证

2018年9月1日

更多信息

与本研究相关的术语

此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.

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