The Effects of Dietary Salt on Post-exercise Hypotension
2019年9月27日 更新者:William Farquhar、University of Delaware
The new American Heart Association (AHA) blood pressure guidelines are expected to raise the prevalence of high blood pressure to ~46% in the United States.
One recommendation for lowering blood pressure is aerobic exercise, which produces a period of lowered blood pressure (post-exercise hypotension; PEH) that lasts up to 24 hours.
It is believed that PEH may be responsible for the observations of lowered blood pressure following initiation of exercise.
However, most Americans eat too much salt, which expands plasma volume and may prevent PEH, rending aerobic exercise ineffective in improving blood pressure status.
研究概览
详细说明
Recently released blood pressure guidelines from the American Heart Association and American College of Cardiology are expected to raise the prevalence of hypertension in America from ~33% to ~46%.
A single bout of aerobic exercise produces a prolonged period (up to 24 hours) of lowered blood pressure (post-exercise hypotension; PEH).
Repeated bouts of aerobic exercise results in maintenance of lowered blood pressure, leading to recommendations of aerobic exercise for improvement of blood pressure status.
However, more than 90% of Americans consume more sodium in their diets than is recommended.
This is alarming, as excess dietary sodium intake expands plasma fluid volume, which may in turn attenuate the reduction in BP following exercise.
Therefore, the objective of this project is to determine the effects of high dietary sodium intake on PEH.
The investigators hypothesize that, compared to a recommended sodium diet, a high salt diet will attenuate post-exercise hypotension.
研究类型
介入性
注册 (实际的)
20
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息,以及有关进行该研究的地点的信息。
学习地点
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Delaware
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Newark、Delaware、美国、19713
- Department of Kinesiology and Applied Physiology, University of Delaware
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参与标准
研究人员寻找符合特定描述的人,称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 至 40年 (成人)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
- Recreationally active
Exclusion Criteria:
- high blood pressure (>140/90 mmHg)
- history of cardiovascular disease
- history of cancer
- history of diabetes
- history of kidney disease
- obesity (BMI > 30 kg/m2)
- smoking or tobacco use
- current pregnancy
- nursing mothers
- communication barriers
学习计划
本节提供研究计划的详细信息,包括研究的设计方式和研究的衡量标准。
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:交叉作业
- 屏蔽:双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:High dietary salt
For 10 days each, participants will be asked to eat a recommended sodium diets (2300 mg Na+/d) while taking unmarked pills containing uniodized table salt.
On the 10th day, participants will report to the lab to complete 60 minutes of cycling exercise.
Following exercise, participants will rest for 60 minutes while undergoing serial blood pressure measurements.
Participants will then be outfitted with ambulatory blood pressure cuffs for assessment of blood pressure over the following 24 hours.
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~4,000 mg Na+/day
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实验性的:Placebo
For 10 days each, participants will be asked to eat a recommended sodium diets (2300 mg Na+/d) while taking unmarked pills containing a placebo (dextrose).
Participants will complete both interventions in random order.
On the 10th day, participants will report to the lab to complete 60 minutes of cycling exercise.
Following exercise, participants will rest for 60 minutes while undergoing serial blood pressure measurements.
Participants will then be outfitted with ambulatory blood pressure cuffs for assessment of blood pressure over the following 24 hours.
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dextrose
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Post-exercise hypotension
大体时间:24 hours following exercise
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Change in mean arterial pressure from pre- to post-exercise
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24 hours following exercise
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Blood pressure reactivity
大体时间:10th day of high salt diet
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Change in mean, systolic, and diastolic blood pressure from baseline to exercise
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10th day of high salt diet
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查,以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2018年5月1日
初级完成 (实际的)
2019年6月30日
研究完成 (实际的)
2019年7月1日
研究注册日期
首次提交
2018年6月11日
首先提交符合 QC 标准的
2018年6月11日
首次发布 (实际的)
2018年6月21日
研究记录更新
最后更新发布 (实际的)
2019年10月1日
上次提交的符合 QC 标准的更新
2019年9月27日
最后验证
2019年9月1日
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
High dietary salt的临床试验
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University Hospital Inselspital, Berne招聘中青光眼 | 黄斑变性 | 葡萄膜炎 | 糖尿病性视网膜病变 | 糖尿病性黄斑水肿 | 黄斑水肿 | 视网膜静脉阻塞 | 视神经疾病 | 视网膜脱离 | 黄斑部疾病 | 视网膜疾病 | 视网膜新生血管 | 视网膜动脉阻塞 | 高血压性视网膜病变 | 视网膜水肿 | 视网膜营养不良瑞士
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The Hong Kong Polytechnic UniversityYan Chai Hospital Social Services主动,不招人