Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques
A Novel Co-induction Technique Compared to Standard Inhalational and Intravenous Induction Techniques: a Prospective Randomized Control Study
研究概览
地位
详细说明
Co-induction technique refers to the use of a combination of medications to reach the desired therapeutic target. This technique is considered an approach that can be of a great benefit to patients with chronic medical illnesses and those who have moderate to high risk for general anaesthesia.
In the present study, the investigators examined the safety of a novel co-induction approach that relied on a simple timing and dosing alterations to the classical approaches of inhalational sevoflurane and propofol induction. The significance of this study is to find a reliable safe alternative method of induction that can provide optimal parameters,when compared to the classical methods of induction. The investigators evaluated the time needed for laryngeal mask airway (LMA) insertion, number of LMA insertion trials, succession of LMA insertion, adverse events related to the airway, respiratory and cardiovascular systems, haemodynamic stability and satisfaction scores of enrolled patients.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Amman、约旦、11942
- Jordan University Hospital
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- patients with Age ≥ 65 years.
- American Society of Anaesthesiologists' (ASA) score II or III.
- minimally invasive endoscopic urological procedures.
Exclusion Criteria:
- patient refusal.
- Age < 65 years.
- family history of malignant hyperthermia.
- prolonged surgery that needed intubation.
- body mass index (BMI) > 35 kg/m2.
学习计划
研究是如何设计的?
设计细节
- 主要用途:预防
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的:Group P
Patient received a dose of 1.5 mg/kg of Propofol slowly over 2 minutes for induction.
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Patients were given 1.5 mcg/Kg of fentanyl intravenously.
two minutes after the fentanyl dose, a dose of 1.5 mg/kg of propofol slowly over 2 minutes.
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实验性的:Group S
Patient received 8% sevoflurane through sealed plastic facemask at 8 L/min flow of oxygen.
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Patients were given 1.5 mcg/Kg of fentanyl intravenously.
two minutes after the fentanyl dose, patient received 8% inhalational sevoflurane through sealed plastic face mask at 8 L/min flow of oxygen.
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实验性的:Group C
Patient received 4% sevoflurane through sealed plastic facemask at 8 L/min flow of oxygen for 2 minutes, followed by a dose of 0.75 mg/kg of propofol given slowly.
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Patients were given 1.5 mcg/Kg of fentanyl intravenously.
two minutes after the fentanyl dose, patient received 4% sevoflurane through sealed plastic face mask at 8 L/min flow of oxygen for 2 minutes, followed by a dose of 0.75 mg/kg of propofol given slowly.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Intraoperative respiratory adverse events
大体时间:8 months
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The investigators recorded the occurrence of transient apnea intraoperatively, in addition to laryngeal spasm, coughing, gagging and increased salivation.
The study chart included the documentation these common adverse events, the timing of occurrence, and the intervention required to manage these events.
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8 months
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Time for successful laryngeal mask airway insertion
大体时间:8 months
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The investigators assessed the time needed for LMA insertion.
The timer was started upon giving the fentanyl, recording the time till successful insertion of laryngeal mask airway.
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8 months
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Blood pressure stability
大体时间:8 months
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The investigators recorded patients' blood pressure readings throughout the induction procedure.
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8 months
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Heart rate stability
大体时间:8 months
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The investigators recorded patients' heart rate throughout the induction procedure.
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8 months
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Changes in oxygen saturation
大体时间:8 months
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The investigators recorded patients' oxygen saturation throughout the induction procedure.
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8 months
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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Induction using propofol的临床试验
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Kaohsiung Medical University Chung-Ho Memorial...Tri-Service General Hospital招聘中